Skip to main content
Top
Published in: Indian Journal of Surgical Oncology 2/2014

01-06-2014 | Review Article

Chemotherapy and Targeted Therapy for Gall Bladder Cancer

Authors: Bhawna Sirohi, Ashish Singh, P. Jagannath, Shailesh V. Shrikhande

Published in: Indian Journal of Surgical Oncology | Issue 2/2014

Login to get access

Abstract

Gall bladder cancer is a common cancer in the Ganges belt of North-eastern India. In view of incidental diagnosis of gall bladder cancer by physicians and surgeons, the treatment is not optimised. Most patients present in advanced stages and surgery remains the only option to cure. This review highlights the current evidence in advances in systemic therapy of gall bladder cancer.
Literature
1.
go back to reference Mahantshetty UM, Palled SR, Engineer R, Homkar G, Shrivastava SK, Shukla PJ (2006) Adjuvant radiation therapy in gall bladder cancers: 10 years experience at Tata memorial hospital. J Cancer Res Ther 2(2):52–56PubMedCrossRef Mahantshetty UM, Palled SR, Engineer R, Homkar G, Shrivastava SK, Shukla PJ (2006) Adjuvant radiation therapy in gall bladder cancers: 10 years experience at Tata memorial hospital. J Cancer Res Ther 2(2):52–56PubMedCrossRef
2.
go back to reference Jarnagin WR, Ruo L, Little SA, Klimstra D, D’Angelica M, DeMatteo RP et al (2003) Patterns of initial disease recurrence after resection of gallbladder carcinoma and hilar cholangiocarcinoma: implications for adjuvant therapeutic strategies. Cancer 98(8):1689–1700PubMedCrossRef Jarnagin WR, Ruo L, Little SA, Klimstra D, D’Angelica M, DeMatteo RP et al (2003) Patterns of initial disease recurrence after resection of gallbladder carcinoma and hilar cholangiocarcinoma: implications for adjuvant therapeutic strategies. Cancer 98(8):1689–1700PubMedCrossRef
3.
go back to reference Murakami Y, Uemura K, Sudo T, Hayashidani Y, Hashimoto Y, Nakamura H et al (2009) Adjuvant gemcitabine plus S-1 chemotherapy improves survival after aggressive surgical resection for advanced biliary carcinoma. Ann Surg 250(6):950–956PubMedCrossRef Murakami Y, Uemura K, Sudo T, Hayashidani Y, Hashimoto Y, Nakamura H et al (2009) Adjuvant gemcitabine plus S-1 chemotherapy improves survival after aggressive surgical resection for advanced biliary carcinoma. Ann Surg 250(6):950–956PubMedCrossRef
4.
go back to reference Morrow CE, Sutherland DE, Florack G, Eisenberg MM, Grage TB (1983) Primary gallbladder carcinoma: significance of subserosal lesions and results of aggressive surgical treatment and adjuvant chemotherapy. Surgery 94(4):709–714PubMed Morrow CE, Sutherland DE, Florack G, Eisenberg MM, Grage TB (1983) Primary gallbladder carcinoma: significance of subserosal lesions and results of aggressive surgical treatment and adjuvant chemotherapy. Surgery 94(4):709–714PubMed
5.
go back to reference Oswalt CE, Cruz AB Jr (1977) Effectiveness of chemotherapy in addition to surgery in treating carcinoma of the gallbladder. Rev Surg 34(6):436–438PubMed Oswalt CE, Cruz AB Jr (1977) Effectiveness of chemotherapy in addition to surgery in treating carcinoma of the gallbladder. Rev Surg 34(6):436–438PubMed
6.
go back to reference Takada T, Amano H, Yasuda H, Nimura Y, Matsushiro T, Kato H et al (2002) Is postoperative adjuvant chemotherapy useful for gallbladder carcinoma? A phase III multicenter prospective randomized controlled trial in patients with resected pancreaticobiliary carcinoma. Cancer 95(8):1685–1695PubMedCrossRef Takada T, Amano H, Yasuda H, Nimura Y, Matsushiro T, Kato H et al (2002) Is postoperative adjuvant chemotherapy useful for gallbladder carcinoma? A phase III multicenter prospective randomized controlled trial in patients with resected pancreaticobiliary carcinoma. Cancer 95(8):1685–1695PubMedCrossRef
7.
go back to reference Duffy A, Capanu M, Abou-Alfa GK, Huitzil D, Jarnagin W, Fong Y et al (2008) Gallbladder cancer (GBC): 10-year experience at memorial sloan-kettering cancer centre (MSKCC). J Surg Oncol 98(7):485–489PubMedCrossRef Duffy A, Capanu M, Abou-Alfa GK, Huitzil D, Jarnagin W, Fong Y et al (2008) Gallbladder cancer (GBC): 10-year experience at memorial sloan-kettering cancer centre (MSKCC). J Surg Oncol 98(7):485–489PubMedCrossRef
8.
go back to reference Valle J, Wasan H, Palmer DH, Cunningham D, Anthoney A, Maraveyas A et al (2010) Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N Engl J Med 362(14):1273–1281PubMedCrossRef Valle J, Wasan H, Palmer DH, Cunningham D, Anthoney A, Maraveyas A et al (2010) Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N Engl J Med 362(14):1273–1281PubMedCrossRef
9.
go back to reference Nakeeb A, Tran KQ, Black MJ, Erickson BA, Ritch PS, Quebbeman EJ (2002) Improved survival in resected biliary malignancies. Surgery 132(4):555–563, discission 563–564PubMedCrossRef Nakeeb A, Tran KQ, Black MJ, Erickson BA, Ritch PS, Quebbeman EJ (2002) Improved survival in resected biliary malignancies. Surgery 132(4):555–563, discission 563–564PubMedCrossRef
10.
go back to reference Mojica P, Smith D, Ellenhorn J (2007) Adjuvant radiation therapy is associated with improved survival for gallbladder carcinoma with regional metastatic disease. J Surg Oncol 96(1):8–13PubMedCrossRef Mojica P, Smith D, Ellenhorn J (2007) Adjuvant radiation therapy is associated with improved survival for gallbladder carcinoma with regional metastatic disease. J Surg Oncol 96(1):8–13PubMedCrossRef
11.
go back to reference Kraybill WG, Lee H, Picus J, Ramachandran G, Lopez MJ, Kucik N et al (1994) Multidisciplinary treatment of biliary tract cancers. J Surg Oncol 55(4):239–245PubMedCrossRef Kraybill WG, Lee H, Picus J, Ramachandran G, Lopez MJ, Kucik N et al (1994) Multidisciplinary treatment of biliary tract cancers. J Surg Oncol 55(4):239–245PubMedCrossRef
12.
go back to reference Gold DG, Miller RC, Haddock MG, Gunderson LL, Quevedo F, Donohue JH et al (2009) Adjuvant therapy for gallbladder carcinoma: the Mayo clinic experience. Int J Radiat Oncol Biol Phys 75(1):150–155PubMedCrossRef Gold DG, Miller RC, Haddock MG, Gunderson LL, Quevedo F, Donohue JH et al (2009) Adjuvant therapy for gallbladder carcinoma: the Mayo clinic experience. Int J Radiat Oncol Biol Phys 75(1):150–155PubMedCrossRef
13.
go back to reference Todoroki T, Kawamoto T, Takahashi H, Takada Y, Koike N, Otsuka M et al (1999) Treatment of gallbladder cancer by radical resection. Br J Surg 86(5):622–627PubMedCrossRef Todoroki T, Kawamoto T, Takahashi H, Takada Y, Koike N, Otsuka M et al (1999) Treatment of gallbladder cancer by radical resection. Br J Surg 86(5):622–627PubMedCrossRef
14.
go back to reference Mahe M, Stampfli C, Romestaing P, Salerno N, Gerard JP (1994) Primary carcinoma of the gall-bladder: potential for external radiation therapy. Radiother Oncol J Eur Soc Ther Radiol Oncol 33(3):204–208CrossRef Mahe M, Stampfli C, Romestaing P, Salerno N, Gerard JP (1994) Primary carcinoma of the gall-bladder: potential for external radiation therapy. Radiother Oncol J Eur Soc Ther Radiol Oncol 33(3):204–208CrossRef
15.
go back to reference Mehta A, Bahadur AK, Aranya RC, Jain AK (1996) Role of radiation therapy in carcinoma of the gall bladder–a preliminary indian experience. Trop Gastroenterol Off J Dig Dis Found 17(1):22–25 Mehta A, Bahadur AK, Aranya RC, Jain AK (1996) Role of radiation therapy in carcinoma of the gall bladder–a preliminary indian experience. Trop Gastroenterol Off J Dig Dis Found 17(1):22–25
16.
go back to reference Nadler LH, McSherry CK (1992) Carcinoma of the gallbladder: review of the literature and report on 56 cases at the Beth Israel medical center. Mt Sinai J Med N Y 59(1):47–52 Nadler LH, McSherry CK (1992) Carcinoma of the gallbladder: review of the literature and report on 56 cases at the Beth Israel medical center. Mt Sinai J Med N Y 59(1):47–52
17.
go back to reference Kresl JJ, Schild SE, Henning GT, Gunderson LL, Donohue J, Pitot H et al (2002) Adjuvant external beam radiation therapy with concurrent chemotherapy in the management of gallbladder carcinoma. Int J Radiat Oncol Biol Phys 52(1):167–175PubMedCrossRef Kresl JJ, Schild SE, Henning GT, Gunderson LL, Donohue J, Pitot H et al (2002) Adjuvant external beam radiation therapy with concurrent chemotherapy in the management of gallbladder carcinoma. Int J Radiat Oncol Biol Phys 52(1):167–175PubMedCrossRef
18.
go back to reference Bosset JF, Mantion G, Gillet M, Pelissier E, Boulenger M, Maingon P (1989) Primary carcinoma of the gallbladder. Adjuvant postoperative external irradiation. Cancer 64(9):1843–1847PubMedCrossRef Bosset JF, Mantion G, Gillet M, Pelissier E, Boulenger M, Maingon P (1989) Primary carcinoma of the gallbladder. Adjuvant postoperative external irradiation. Cancer 64(9):1843–1847PubMedCrossRef
19.
go back to reference Todoroki T, Kawamoto T, Otsuka M, Koike N, Yoshida S, Takada Y et al (1999) Benefits of combining radiotherapy with aggressive resection for stage IV gallbladder cancer. Hepatogastroenterology 46(27):1585–1591PubMed Todoroki T, Kawamoto T, Otsuka M, Koike N, Yoshida S, Takada Y et al (1999) Benefits of combining radiotherapy with aggressive resection for stage IV gallbladder cancer. Hepatogastroenterology 46(27):1585–1591PubMed
20.
go back to reference Houry S, Barrier A, Huguier M (2001) Irradiation therapy for gallbladder carcinoma: recent advances. J Hepatobiliary Pancreat Surg 8(6):518–524PubMedCrossRef Houry S, Barrier A, Huguier M (2001) Irradiation therapy for gallbladder carcinoma: recent advances. J Hepatobiliary Pancreat Surg 8(6):518–524PubMedCrossRef
21.
go back to reference Czito BG, Hurwitz HI, Clough RW, Tyler DS, Morse MA, Clary BM et al (2005) Adjuvant external-beam radiotherapy with concurrent chemotherapy after resection of primary gallbladder carcinoma: a 23-year experience. Int J Radiat Oncol Biol Phys 62(4):1030–1034PubMedCrossRef Czito BG, Hurwitz HI, Clough RW, Tyler DS, Morse MA, Clary BM et al (2005) Adjuvant external-beam radiotherapy with concurrent chemotherapy after resection of primary gallbladder carcinoma: a 23-year experience. Int J Radiat Oncol Biol Phys 62(4):1030–1034PubMedCrossRef
22.
go back to reference Cho SY, Kim SH, Park S-J, Han S-S, Kim Y-K, Lee K-W et al (2010) Adjuvant chemoradiation therapy in gallbladder cancer. J Surg Oncol 102(1):87–93PubMedCrossRef Cho SY, Kim SH, Park S-J, Han S-S, Kim Y-K, Lee K-W et al (2010) Adjuvant chemoradiation therapy in gallbladder cancer. J Surg Oncol 102(1):87–93PubMedCrossRef
23.
24.
go back to reference Itoh H, Nishijima K, Kurosaka Y, Takegawa S, Kiriyama M, Dohba S et al (2005) Magnitude of combination therapy of radical resection and external beam radiotherapy for patients with carcinomas of the extrahepatic bile duct and gallbladder. Dig Dis Sci 50(12):2231–2242PubMedCrossRef Itoh H, Nishijima K, Kurosaka Y, Takegawa S, Kiriyama M, Dohba S et al (2005) Magnitude of combination therapy of radical resection and external beam radiotherapy for patients with carcinomas of the extrahepatic bile duct and gallbladder. Dig Dis Sci 50(12):2231–2242PubMedCrossRef
25.
go back to reference Todoroki T, Iwasaki Y, Orii K, Otsuka M, Ohara K, Kawamoto T et al (1991) Resection combined with intraoperative radiation therapy (IORT) for stage IV (TNM) gallbladder carcinoma. World J Surg 15(3):357–366PubMedCrossRef Todoroki T, Iwasaki Y, Orii K, Otsuka M, Ohara K, Kawamoto T et al (1991) Resection combined with intraoperative radiation therapy (IORT) for stage IV (TNM) gallbladder carcinoma. World J Surg 15(3):357–366PubMedCrossRef
26.
go back to reference Busse PM, Cady B, Bothe A Jr, Jenkins R, McDermott WV, Steele G Jr et al (1991) Intraoperative radiation therapy for carcinoma of the gallbladder. World J Surg 15(3):352–356PubMedCrossRef Busse PM, Cady B, Bothe A Jr, Jenkins R, McDermott WV, Steele G Jr et al (1991) Intraoperative radiation therapy for carcinoma of the gallbladder. World J Surg 15(3):352–356PubMedCrossRef
27.
go back to reference Lindell G, Holmin T, Ewers SB, Tranberg K-G, Stenram U, Ihse I (2003) Extended operation with or without intraoperative (IORT) and external (EBRT) radiotherapy for gallbladder carcinoma. Hepatogastroenterology 50(50):310–314PubMed Lindell G, Holmin T, Ewers SB, Tranberg K-G, Stenram U, Ihse I (2003) Extended operation with or without intraoperative (IORT) and external (EBRT) radiotherapy for gallbladder carcinoma. Hepatogastroenterology 50(50):310–314PubMed
28.
go back to reference Horgan AM, Amir E, Walter T, Knox JJ (2012) Adjuvant therapy in the treatment of biliary tract cancer: a systematic review and meta-analysis. J Clin Oncol 30(16):1934–1940PubMedCrossRef Horgan AM, Amir E, Walter T, Knox JJ (2012) Adjuvant therapy in the treatment of biliary tract cancer: a systematic review and meta-analysis. J Clin Oncol 30(16):1934–1940PubMedCrossRef
29.
go back to reference Wang SJ, Lemieux A, Kalpathy-Cramer J, Ord CB, Walker GV, Fuller CD et al (2011) Nomogram for predicting the benefit of adjuvant chemoradiotherapy for resected gallbladder cancer. J Clin Oncol Off J Am Soc Clin Oncol 29(35):4627–4632CrossRef Wang SJ, Lemieux A, Kalpathy-Cramer J, Ord CB, Walker GV, Fuller CD et al (2011) Nomogram for predicting the benefit of adjuvant chemoradiotherapy for resected gallbladder cancer. J Clin Oncol Off J Am Soc Clin Oncol 29(35):4627–4632CrossRef
30.
go back to reference Sirohi B, Singh A, Seth V. Neoadjuvant therapy in Indian patients with locally advanced gall bladder cancer: Tata Memorial Centre (TMC) experience. J Clin Oncol 32 2014 Suppl 3 Abstr 379 [Internet]. [cited 2014 Jan 18]; Available from: http://gicasym.org/content/122842-143 Sirohi B, Singh A, Seth V. Neoadjuvant therapy in Indian patients with locally advanced gall bladder cancer: Tata Memorial Centre (TMC) experience. J Clin Oncol 32 2014 Suppl 3 Abstr 379 [Internet]. [cited 2014 Jan 18]; Available from: http://​gicasym.​org/​content/​122842-143
31.
go back to reference De Aretxabala X, Roa I, Berrios M, Hepp J, Gallardo J, Cordova A et al (2006) Chemoradiotherapy in gallbladder cancer. J Surg Oncol 93(8):699–704PubMedCrossRef De Aretxabala X, Roa I, Berrios M, Hepp J, Gallardo J, Cordova A et al (2006) Chemoradiotherapy in gallbladder cancer. J Surg Oncol 93(8):699–704PubMedCrossRef
32.
go back to reference De Aretxabala X, Losada H, Mora J, Roa I, Burgos L, Yáñez E (2004) [Neoadjuvant chemoradiotherapy in gallbladder cancer]. Rev Médica Chile 132(1):51–57 De Aretxabala X, Losada H, Mora J, Roa I, Burgos L, Yáñez E (2004) [Neoadjuvant chemoradiotherapy in gallbladder cancer]. Rev Médica Chile 132(1):51–57
33.
go back to reference Engineer R, Wadasadawala T, Mehta S, Mahantshetty U, Purandare N, Rangarajan V et al (2011) Chemoradiation for unresectable gall bladder cancer: time to review historic nihilism? J Gastrointest Cancer 42(4):222–227PubMedCrossRef Engineer R, Wadasadawala T, Mehta S, Mahantshetty U, Purandare N, Rangarajan V et al (2011) Chemoradiation for unresectable gall bladder cancer: time to review historic nihilism? J Gastrointest Cancer 42(4):222–227PubMedCrossRef
34.
go back to reference Kumaran V, Gulati S, Paul B, Pande K, Sahni P, Chattopadhyay K (2002) The role of dual-phase helical CT in assessing resectability of carcinoma of the gallbladder. Eur Radiol 12(8):1993–1999PubMedCrossRef Kumaran V, Gulati S, Paul B, Pande K, Sahni P, Chattopadhyay K (2002) The role of dual-phase helical CT in assessing resectability of carcinoma of the gallbladder. Eur Radiol 12(8):1993–1999PubMedCrossRef
35.
go back to reference Saluja SS, Gulati M, Garg PK, Pal H, Pal S, Sahni P (2008) Endoscopic or percutaneous biliary drainage for gallbladder cancer: a randomized trial and quality of life assessment. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc 6(8):944–950 Saluja SS, Gulati M, Garg PK, Pal H, Pal S, Sahni P (2008) Endoscopic or percutaneous biliary drainage for gallbladder cancer: a randomized trial and quality of life assessment. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc 6(8):944–950
36.
go back to reference Sharma A, Dwary AD, Mohanti BK, Deo SV, Pal S, Sreenivas V et al (2010) Best supportive care compared with chemotherapy for unresectable gall bladder cancer: a randomized controlled study. J Clin Oncol Off J Am Soc Clin Oncol 28(30):4581–4586CrossRef Sharma A, Dwary AD, Mohanti BK, Deo SV, Pal S, Sreenivas V et al (2010) Best supportive care compared with chemotherapy for unresectable gall bladder cancer: a randomized controlled study. J Clin Oncol Off J Am Soc Clin Oncol 28(30):4581–4586CrossRef
37.
go back to reference Patt YZ, Hassan MM, Aguayo A, Nooka AK, Lozano RD, Curley SA et al (2004) Oral capecitabine for the treatment of hepatocellular carcinoma, cholangiocarcinoma, and gallbladder carcinoma. Cancer 101(3):578–586PubMedCrossRef Patt YZ, Hassan MM, Aguayo A, Nooka AK, Lozano RD, Curley SA et al (2004) Oral capecitabine for the treatment of hepatocellular carcinoma, cholangiocarcinoma, and gallbladder carcinoma. Cancer 101(3):578–586PubMedCrossRef
38.
go back to reference Ducreux M, Rougier P, Fandi A, Clavero-Fabri MC, Villing AL, Fassone F et al (1998) Effective treatment of advanced biliary tract carcinoma using 5-fluorouracil continuous infusion with cisplatin. Ann Oncol Off J Eur Soc Med Oncol ESMO 9(6):653–656CrossRef Ducreux M, Rougier P, Fandi A, Clavero-Fabri MC, Villing AL, Fassone F et al (1998) Effective treatment of advanced biliary tract carcinoma using 5-fluorouracil continuous infusion with cisplatin. Ann Oncol Off J Eur Soc Med Oncol ESMO 9(6):653–656CrossRef
39.
go back to reference Rao S, Cunningham D, Hawkins RE, Hill ME, Smith D, Daniel F et al (2005) Phase III study of 5FU, etoposide and leucovorin (FELV) compared to epirubicin, cisplatin and 5FU (ECF) in previously untreated patients with advanced biliary cancer. Br J Cancer 92(9):1650–1654PubMedCentralPubMedCrossRef Rao S, Cunningham D, Hawkins RE, Hill ME, Smith D, Daniel F et al (2005) Phase III study of 5FU, etoposide and leucovorin (FELV) compared to epirubicin, cisplatin and 5FU (ECF) in previously untreated patients with advanced biliary cancer. Br J Cancer 92(9):1650–1654PubMedCentralPubMedCrossRef
40.
go back to reference Nehls O, Oettle H, Hartmann JT, Hofheinz R-D, Hass HG, Horger MS et al (2008) Capecitabine plus oxaliplatin as first-line treatment in patients with advanced biliary system adenocarcinoma: a prospective multicentre phase II trial. Br J Cancer 98(2):309–315PubMedCentralPubMedCrossRef Nehls O, Oettle H, Hartmann JT, Hofheinz R-D, Hass HG, Horger MS et al (2008) Capecitabine plus oxaliplatin as first-line treatment in patients with advanced biliary system adenocarcinoma: a prospective multicentre phase II trial. Br J Cancer 98(2):309–315PubMedCentralPubMedCrossRef
41.
go back to reference Riechelmann RP, Townsley CA, Chin SN, Pond GR, Knox JJ (2007) Expanded phase II trial of gemcitabine and capecitabine for advanced biliary cancer. Cancer 110(6):1307–1312PubMedCrossRef Riechelmann RP, Townsley CA, Chin SN, Pond GR, Knox JJ (2007) Expanded phase II trial of gemcitabine and capecitabine for advanced biliary cancer. Cancer 110(6):1307–1312PubMedCrossRef
42.
go back to reference Cho J-Y, Nam J-S, Park M-S, Yu J-S, Paik Y-H, Lee S-J et al (2005) A Phase II study of capecitabine combined with gemcitabine in patients with advanced gallbladder carcinoma. Yonsei Med J 46(4):526–531PubMedCentralPubMedCrossRef Cho J-Y, Nam J-S, Park M-S, Yu J-S, Paik Y-H, Lee S-J et al (2005) A Phase II study of capecitabine combined with gemcitabine in patients with advanced gallbladder carcinoma. Yonsei Med J 46(4):526–531PubMedCentralPubMedCrossRef
43.
go back to reference Valle JW, Furuse J, Jitlal M, Beare S, Mizuno N, Wasan H, et al. Cisplatin and gemcitabine for advanced biliary tract cancer: a meta-analysis of two randomised trials. Ann Oncol Off J Eur Soc Med Oncol ESMO. 2013 Dec 18; Valle JW, Furuse J, Jitlal M, Beare S, Mizuno N, Wasan H, et al. Cisplatin and gemcitabine for advanced biliary tract cancer: a meta-analysis of two randomised trials. Ann Oncol Off J Eur Soc Med Oncol ESMO. 2013 Dec 18;
44.
go back to reference André T, Tournigand C, Rosmorduc O, Provent S, Maindrault-Goebel F, Avenin D et al (2004) Gemcitabine combined with oxaliplatin (GEMOX) in advanced biliary tract adenocarcinoma: a GERCOR study. Ann Oncol Off J Eur Soc Med Oncol ESMO 15(9):1339–1343CrossRef André T, Tournigand C, Rosmorduc O, Provent S, Maindrault-Goebel F, Avenin D et al (2004) Gemcitabine combined with oxaliplatin (GEMOX) in advanced biliary tract adenocarcinoma: a GERCOR study. Ann Oncol Off J Eur Soc Med Oncol ESMO 15(9):1339–1343CrossRef
45.
go back to reference Philip PA, Mahoney MR, Allmer C, Thomas J, Pitot HC, Kim G et al (2006) Phase II study of erlotinib in patients with advanced biliary cancer. J Clin Oncol Off J Am Soc Clin Oncol 24(19):3069–3074CrossRef Philip PA, Mahoney MR, Allmer C, Thomas J, Pitot HC, Kim G et al (2006) Phase II study of erlotinib in patients with advanced biliary cancer. J Clin Oncol Off J Am Soc Clin Oncol 24(19):3069–3074CrossRef
46.
go back to reference Lubner SJ, Mahoney MR, Kolesar JL, Loconte NK, Kim GP, Pitot HC et al (2010) Report of a multicenter phase II trial testing a combination of biweekly bevacizumab and daily erlotinib in patients with unresectable biliary cancer: a phase II Consortium study. J Clin Oncol Off J Am Soc Clin Oncol 28(21):3491–3497CrossRef Lubner SJ, Mahoney MR, Kolesar JL, Loconte NK, Kim GP, Pitot HC et al (2010) Report of a multicenter phase II trial testing a combination of biweekly bevacizumab and daily erlotinib in patients with unresectable biliary cancer: a phase II Consortium study. J Clin Oncol Off J Am Soc Clin Oncol 28(21):3491–3497CrossRef
48.
go back to reference Ben-David MA, Griffith KA, Abu-Isa E, Lawrence TS, Knol J, Zalupski M et al (2006) External-beam radiotherapy for localized extrahepatic cholangiocarcinoma. Int J Radiat Oncol Biol Phys 66(3):772–779PubMedCrossRef Ben-David MA, Griffith KA, Abu-Isa E, Lawrence TS, Knol J, Zalupski M et al (2006) External-beam radiotherapy for localized extrahepatic cholangiocarcinoma. Int J Radiat Oncol Biol Phys 66(3):772–779PubMedCrossRef
49.
go back to reference González ME, Giannini OH, González P, Saldaña B (2011) Adjuvant radio-chemotherapy after extended or simple cholecystectomy in gallbladder cancer. Clin Transl Oncol Off Publ Fed Span Oncol Soc Natl Cancer Inst Mex 13(7):480–484 González ME, Giannini OH, González P, Saldaña B (2011) Adjuvant radio-chemotherapy after extended or simple cholecystectomy in gallbladder cancer. Clin Transl Oncol Off Publ Fed Span Oncol Soc Natl Cancer Inst Mex 13(7):480–484
50.
go back to reference De Aretxabala X, Roa I, Burgos L, Cartes R, Silva J, Yañez E et al (1999) Preoperative chemoradiotherapy in the treatment of gallbladder cancer. Am Surg 65(3):241–246PubMed De Aretxabala X, Roa I, Burgos L, Cartes R, Silva J, Yañez E et al (1999) Preoperative chemoradiotherapy in the treatment of gallbladder cancer. Am Surg 65(3):241–246PubMed
51.
go back to reference Okusaka T, Nakachi K, Fukutomi A, Mizuno N, Ohkawa S, Funakoshi A et al (2010) Gemcitabine alone or in combination with cisplatin in patients with biliary tract cancer: a comparative multicentre study in Japan. Br J Cancer 103(4):469–474PubMedCentralPubMedCrossRef Okusaka T, Nakachi K, Fukutomi A, Mizuno N, Ohkawa S, Funakoshi A et al (2010) Gemcitabine alone or in combination with cisplatin in patients with biliary tract cancer: a comparative multicentre study in Japan. Br J Cancer 103(4):469–474PubMedCentralPubMedCrossRef
52.
go back to reference Knox JJ, Hedley D, Oza A, Feld R, Siu LL, Chen E et al (2005) Combining gemcitabine and capecitabine in patients with advanced biliary cancer: a phase II trial. J Clin Oncol Off J Am Soc Clin Oncol 23(10):2332–2338CrossRef Knox JJ, Hedley D, Oza A, Feld R, Siu LL, Chen E et al (2005) Combining gemcitabine and capecitabine in patients with advanced biliary cancer: a phase II trial. J Clin Oncol Off J Am Soc Clin Oncol 23(10):2332–2338CrossRef
53.
go back to reference Cho JY, Paik YH, Chang YS, Lee SJ, Lee D-K, Song SY et al (2005) Capecitabine combined with gemcitabine (CapGem) as first-line treatment in patients with advanced/metastatic biliary tract carcinoma. Cancer 104(12):2753–2758PubMedCrossRef Cho JY, Paik YH, Chang YS, Lee SJ, Lee D-K, Song SY et al (2005) Capecitabine combined with gemcitabine (CapGem) as first-line treatment in patients with advanced/metastatic biliary tract carcinoma. Cancer 104(12):2753–2758PubMedCrossRef
54.
go back to reference Iyer RV, Gibbs J, Kuvshinoff B, Fakih M, Kepner J, Soehnlein N et al (2007) A phase II study of gemcitabine and capecitabine in advanced cholangiocarcinoma and carcinoma of the gallbladder: a single-institution prospective study. Ann Surg Oncol 14(11):3202–3209PubMedCrossRef Iyer RV, Gibbs J, Kuvshinoff B, Fakih M, Kepner J, Soehnlein N et al (2007) A phase II study of gemcitabine and capecitabine in advanced cholangiocarcinoma and carcinoma of the gallbladder: a single-institution prospective study. Ann Surg Oncol 14(11):3202–3209PubMedCrossRef
55.
go back to reference Thongprasert S, Napapan S, Charoentum C, Moonprakan S (2005) Phase II study of gemcitabine and cisplatin as first-line chemotherapy in inoperable biliary tract carcinoma. Ann Oncol Off J Eur Soc Med Oncol ESMO 16(2):279–281CrossRef Thongprasert S, Napapan S, Charoentum C, Moonprakan S (2005) Phase II study of gemcitabine and cisplatin as first-line chemotherapy in inoperable biliary tract carcinoma. Ann Oncol Off J Eur Soc Med Oncol ESMO 16(2):279–281CrossRef
56.
go back to reference Meyerhardt JA, Zhu AX, Stuart K, Ryan DP, Blaszkowsky L, Lehman N et al (2008) Phase-II study of gemcitabine and cisplatin in patients with metastatic biliary and gallbladder cancer. Dig Dis Sci 53(2):564–570PubMedCrossRef Meyerhardt JA, Zhu AX, Stuart K, Ryan DP, Blaszkowsky L, Lehman N et al (2008) Phase-II study of gemcitabine and cisplatin in patients with metastatic biliary and gallbladder cancer. Dig Dis Sci 53(2):564–570PubMedCrossRef
57.
go back to reference Kim ST, Park JO, Lee J, Lee KT, Lee JK, Choi S-H et al (2006) A Phase II study of gemcitabine and cisplatin in advanced biliary tract cancer. Cancer 106(6):1339–1346PubMedCrossRef Kim ST, Park JO, Lee J, Lee KT, Lee JK, Choi S-H et al (2006) A Phase II study of gemcitabine and cisplatin in advanced biliary tract cancer. Cancer 106(6):1339–1346PubMedCrossRef
58.
go back to reference Harder J, Riecken B, Kummer O, Lohrmann C, Otto F, Usadel H et al (2006) Outpatient chemotherapy with gemcitabine and oxaliplatin in patients with biliary tract cancer. Br J Cancer 95(7):848–852PubMedCentralPubMedCrossRef Harder J, Riecken B, Kummer O, Lohrmann C, Otto F, Usadel H et al (2006) Outpatient chemotherapy with gemcitabine and oxaliplatin in patients with biliary tract cancer. Br J Cancer 95(7):848–852PubMedCentralPubMedCrossRef
59.
go back to reference Verderame F, Russo A, Di Leo R, Badalamenti G, Santangelo D, Cicero G, et al. Gemcitabine and oxaliplatin combination chemotherapy in advanced biliary tract cancers. Ann Oncol Off J Eur Soc Med Oncol ESMO. 2006 Jun;17 Suppl 7:vii68–72. Verderame F, Russo A, Di Leo R, Badalamenti G, Santangelo D, Cicero G, et al. Gemcitabine and oxaliplatin combination chemotherapy in advanced biliary tract cancers. Ann Oncol Off J Eur Soc Med Oncol ESMO. 2006 Jun;17 Suppl 7:vii68–72.
60.
go back to reference Doval DC, Sekhon JS, Gupta SK, Fuloria J, Shukla VK, Gupta S et al (2004) A phase II study of gemcitabine and cisplatin in chemotherapy-naive, unresectable gall bladder cancer. Br J Cancer 90(8):1516–1520PubMedCentralPubMedCrossRef Doval DC, Sekhon JS, Gupta SK, Fuloria J, Shukla VK, Gupta S et al (2004) A phase II study of gemcitabine and cisplatin in chemotherapy-naive, unresectable gall bladder cancer. Br J Cancer 90(8):1516–1520PubMedCentralPubMedCrossRef
61.
go back to reference Gallardo JO, Rubio B, Fodor M, Orlandi L, Yáñez M, Gamargo C et al (2001) A phase II study of gemcitabine in gallbladder carcinoma. Ann Oncol Off J Eur Soc Med Oncol ESMO 12(10):1403–1406CrossRef Gallardo JO, Rubio B, Fodor M, Orlandi L, Yáñez M, Gamargo C et al (2001) A phase II study of gemcitabine in gallbladder carcinoma. Ann Oncol Off J Eur Soc Med Oncol ESMO 12(10):1403–1406CrossRef
62.
go back to reference Gruenberger B, Schueller J, Heubrandtner U, Wrba F, Tamandl D, Kaczirek K et al (2010) Cetuximab, gemcitabine, and oxaliplatin in patients with unresectable advanced or metastatic biliary tract cancer: a phase 2 study. Lancet Oncol 11(12):1142–1148PubMedCrossRef Gruenberger B, Schueller J, Heubrandtner U, Wrba F, Tamandl D, Kaczirek K et al (2010) Cetuximab, gemcitabine, and oxaliplatin in patients with unresectable advanced or metastatic biliary tract cancer: a phase 2 study. Lancet Oncol 11(12):1142–1148PubMedCrossRef
63.
go back to reference Lee J, Park SH, Chang H-M, Kim JS, Choi HJ, Lee MA et al (2012) Gemcitabine and oxaliplatin with or without erlotinib in advanced biliary-tract cancer: a multicentre, open-label, randomised, phase 3 study. Lancet Oncol 13(2):181–188PubMedCrossRef Lee J, Park SH, Chang H-M, Kim JS, Choi HJ, Lee MA et al (2012) Gemcitabine and oxaliplatin with or without erlotinib in advanced biliary-tract cancer: a multicentre, open-label, randomised, phase 3 study. Lancet Oncol 13(2):181–188PubMedCrossRef
64.
go back to reference Jensen LH, Lindebjerg J, Ploen J, Hansen TF, Jakobsen A (2012) Phase II marker-driven trial of panitumumab and chemotherapy in KRAS wild-type biliary tract cancer. Ann Oncol Off J Eur Soc Med Oncol ESMO 23(9):2341–2346CrossRef Jensen LH, Lindebjerg J, Ploen J, Hansen TF, Jakobsen A (2012) Phase II marker-driven trial of panitumumab and chemotherapy in KRAS wild-type biliary tract cancer. Ann Oncol Off J Eur Soc Med Oncol ESMO 23(9):2341–2346CrossRef
65.
go back to reference Sohal DPS, Mykulowycz K, Uehara T, Teitelbaum UR, Damjanov N, Giantonio BJ et al (2013) A phase II trial of gemcitabine, irinotecan and panitumumab in advanced cholangiocarcinoma. Ann Oncol Off J Eur Soc Med Oncol ESMO 24(12):3061–3065CrossRef Sohal DPS, Mykulowycz K, Uehara T, Teitelbaum UR, Damjanov N, Giantonio BJ et al (2013) A phase II trial of gemcitabine, irinotecan and panitumumab in advanced cholangiocarcinoma. Ann Oncol Off J Eur Soc Med Oncol ESMO 24(12):3061–3065CrossRef
66.
go back to reference Zhu AX, Meyerhardt JA, Blaszkowsky LS, Kambadakone AR, Muzikansky A, Zheng H et al (2010) Efficacy and safety of gemcitabine, oxaliplatin, and bevacizumab in advanced biliary-tract cancers and correlation of changes in 18-fluorodeoxyglucose PET with clinical outcome: a phase 2 study. Lancet Oncol 11(1):48–54PubMedCrossRef Zhu AX, Meyerhardt JA, Blaszkowsky LS, Kambadakone AR, Muzikansky A, Zheng H et al (2010) Efficacy and safety of gemcitabine, oxaliplatin, and bevacizumab in advanced biliary-tract cancers and correlation of changes in 18-fluorodeoxyglucose PET with clinical outcome: a phase 2 study. Lancet Oncol 11(1):48–54PubMedCrossRef
67.
go back to reference Bekaii-Saab T, Phelps MA, Li X, Saji M, Goff L, Kauh JSW et al (2011) Multi-institutional phase II study of selumetinib in patients with metastatic biliary cancers. J Clin Oncol Off J Am Soc Clin Oncol 29(17):2357–2363CrossRef Bekaii-Saab T, Phelps MA, Li X, Saji M, Goff L, Kauh JSW et al (2011) Multi-institutional phase II study of selumetinib in patients with metastatic biliary cancers. J Clin Oncol Off J Am Soc Clin Oncol 29(17):2357–2363CrossRef
Metadata
Title
Chemotherapy and Targeted Therapy for Gall Bladder Cancer
Authors
Bhawna Sirohi
Ashish Singh
P. Jagannath
Shailesh V. Shrikhande
Publication date
01-06-2014
Publisher
Springer India
Published in
Indian Journal of Surgical Oncology / Issue 2/2014
Print ISSN: 0975-7651
Electronic ISSN: 0976-6952
DOI
https://doi.org/10.1007/s13193-014-0317-4

Other articles of this Issue 2/2014

Indian Journal of Surgical Oncology 2/2014 Go to the issue

Editorial

Editorial