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01-11-2006 | Original Article

Chemopreventive property of dietary ginger in rat urinary bladder chemical carcinogenesis

Authors: Shadia Muhammad Ihlaseh, Maria Luiza Cotrim de Oliveira, Elizabeth Teràn, João Lauro Viana de Camargo, Luís Fernando Barbisan

Published in: World Journal of Urology | Issue 5/2006

Abstract

The modifying potential of ginger on the development of preneoplasia and tumors in the male Wistar rat urinary bladder was investigated in a 36-week-long initiation-promotion assay for chemical carcinogenesis. Groups G1 to G3 were given 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in drinking water for 5 weeks and a 3% uracil meal for the subsequent 3 weeks. Groups G4 and G5 were treated with 3% uracil only for the same period. After these steps, groups G2, and G3 and G4 were fed for 26 weeks a ginger extract mixed at 0.5 and 1.0% in a basal diet, respectively. Thirty six weeks after the beginning of the experiment all rats were killed. The multiplicity of urothelial lesions (hyperplasia and neoplasia) was significantly lower (P = 0.013) in group G3 than in groups G1 and G2. The results suggest that 1.0% ginger meal exerts a protective effect on the post-initiation stage of rat chemically-induced urothelial carcinogenesis.

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Title: Chemopreventive property of dietary ginger in rat urinary bladder chemical carcinogenesis
Authors: Shadia Muhammad Ihlaseh
Maria Luiza Cotrim de Oliveira
Elizabeth Teràn
João Lauro Viana de Camargo
Luís Fernando Barbisan
Publication date: 01-11-2006
Publisher: Springer-Verlag
Published in: World Journal of Urology / Issue 5/2006
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-006-0108-9

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Chemopreventive property of dietary ginger in rat urinary bladder chemical carcinogenesis

Abstract

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Abstract

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