Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2023

Open Access 01-12-2023 | Research

Chemical profiling and cytotoxic potential of the n-butanol fraction of Tamarix nilotica flowers

Authors: Marwa A. A. Fayed, Riham O. Bakr, Nermeen Yosri, Shaden A. M. Khalifa, Hesham R. El-Seedi, Dalia I. Hamdan, Mohamed S. Refaey

Published in: BMC Complementary Medicine and Therapies | Issue 1/2023

Login to get access

Abstract

Background

Cancer represents one of the biggest healthcare issues confronting humans and one of the big challenges for scientists in trials to dig into our nature for new remedies or to develop old ones with fewer side effects. Halophytes are widely distributed worldwide in areas of harsh conditions in dunes, and inland deserts, where, to cope with those conditions they synthesize important secondary metabolites highly valued in the medical field. Several Tamarix species are halophytic including T.nilotica which is native to Egypt, with a long history in its tradition, found in its papyri and in folk medicine to treat various ailments.

Methods

LC–LTQ–MS–MS analysis and 1H-NMR were used to identify the main phytoconstituents in the n- butanol fraction of T.nilotica flowers. The extract was tested  in vitro for its cytotoxic effect against breast (MCF-7) and liver cell carcinoma (Huh-7) using SRB assay.

Results

T.nilotica n-butanol fraction of the flowers was found to be rich in phenolic content, where, LC–LTQ–MS–MS allowed the tentative identification of thirty-nine metabolites, based on the exact mass, the observed spectra fragmentation patterns, and the literature data, varying between tannins, phenolic acids, and flavonoids. 1H-NMR confirmed the classes tentatively identified. The in-vitro evaluation of the n-butanol fraction showed lower activity on MCF-7 cell lines with IC50 > 100 µg/mL, while the higher promising effect was against Huh-7 cell lines with an IC50= 37 µg/mL.

Conclusion

Our study suggested that T.nilotica flowers' n-butanol fraction is representing a promising cytotoxic candidate against liver cell carcinoma having potential phytoconstituents with variable targets and signaling pathways.
Literature
1.
Bray F, Laversanne M, Weiderpass E, Soerjomataram I. The ever-increasing importance of cancer as a leading cause of premature death worldwide. Cancer. 2021;127(16):3029–30.CrossRefPubMed
2.
El-Seedi HR, Yosri N, Khalifa SAM, Guo Z, Musharraf SG, Xiao J, Saeed A, Du M, Khatib A, Abdel-Daim MM, et al. Exploring natural products-based cancer therapeutics derived from egyptian flora. J Ethnopharmacol. 2021;269:113626.PubMedCrossRef
3.
Reports W. World health statistics 2022: monitoring health for the SDGs, sustainable development goals. Geneva: World Health Organization. In.; 2022.
4.
Chidambaranathan-Reghupaty S, Fisher PB, Sarkar D. Chapter One - Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification. In: Advances in Cancer Research. Volume 149, edn. Edited by Sarkar D, Fisher PB: Academic Press; 2021: 1–61.
5.
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.PubMedCrossRef
6.
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. Cancer J Clin. 2021;71(3):209–49.CrossRef
7.
Breast Cancer Statistics And Resources. In: bcrforg/breasti>-cancer-statistics-and-resources/. Breast Cancer Research Foundation 2023.
8.
Swetha GMS, Keerthana M, Rayginia CK, Anto TP. RJ: Cancer Chemoprevention: A Strategic Approach Using Phytochemicals. Front Pharmacol. 2022;12.
9.
Abosedera DA, Emara SA, Tamam OAS, Badr OM, Khalifa SAM, El-Seedi HR, Refaey MS. Metabolomic Profile and In vitro Evaluation of the Cytotoxic Activity of Asphodelus microcarpus against Human Malignant Melanoma Cells A375. Arab J Chem. 2022:104174.
10.
Abosedera DA, Emara SA, Tamam OAS, Badr OM, Khalifa SAM, El-Seedi HR, Refaey MS. Metabolomic profile and in vitro evaluation of the cytotoxic activity of Asphodelus microcarpus against human malignant melanoma cells A375. Arab J Chem. 2022;15(10):104174.CrossRef
11.
Bahramsoltani R, Kalkhorani M, Abbas Zaidi SM, Farzaei MH, Rahimi R. The genus Tamarix: traditional uses, phytochemistry, and pharmacology. J Ethnopharmacol. 2020;246:112245.PubMedCrossRef
12.
El-Seedi HR, Khalifa SA, Yosri N, Khatib A, Chen L, Saeed A, Efferth T, Verpoorte R. Plants mentioned in the islamic scriptures (Holy Qur’ân and ahadith): traditional uses and medicinal importance in contemporary times. J Ethnopharmacol. 2019;243:112007.PubMedCrossRef
13.
Quattrocchi U. CRC World Dictionary of Medicinal and poisonous plants: common names, scientific names, Eponyms, Synonyms, and etymology. Volume 5, 1st ed. CRC Press; 2012.
14.
Mughal M: Kitab Al-Shifa Bi Ta'Rif Huquq Al-Mustafa (Sallallahu 'Alayhi Wasallam) کِتَابُ الشِّفَاءِ بِتَعۡرِیۡفِ حُقُوۡقِ الۡمُصۡطَفیٰ(صَلَّی للهُ عَلیۡہِ وَآلِہٖ وَسَلَّم) By Qadi ‘Iyad Maliki Andulusi قاضی عیاض مالکی اندلسی(رحمۃ لله علی) Translated into English by Justice ® Dr. Munir Ahmad Mughal [Chapter – 3 (Pages 1 to 1022)]. 2011.
15.
Salissou MTM, Mahaman YAR, Zhu F, Huang F, Wang Y, Xu Z, Ke D, Wang Q, Liu R, Wang JZ, et al. Methanolic extract of Tamarix Gallica attenuates hyperhomocysteinemia induced AD-like pathology and cognitive impairments in rats. Aging. 2018;10(11):3229–48.PubMedPubMedCentralCrossRef
16.
Ullah R, Tariq SA, Khan N, Sharif N, Ud Din Z, Mansoor K. Antihyperglycemic effect of methanol extract of Tamarix aphylla L. Karst (Saltcedar) in streptozocin–nicotinamide induced diabetic rats. Asian Pac J Trop Biomed. 2017;7(7):619–23.CrossRef
17.
Hebi M, Eddouks M. Hypolipidemic activity of Tamarix articulata Vahl. in diabetic rats. J Integr Med. 2017;15(6):476–82.
18.
Bose A, Mondal S, Gupta JK, Ghosh T, Dash GK, Si S. Analgesic, anti-inflammatory and antipyretic activities of the ethanolic extract and its fractions of Cleome rutidosperma. Fitoterapia. 2007;78(7–8):515–20.PubMedCrossRef
19.
Chen R, Yang Y, Xu J, Pan Y, Zhang W, Xing Y, Ni H, Sun Y, Hou Y, Li N. Tamarix hohenackeri Bunge exerts anti-inflammatory effects on lipopolysaccharide-activated microglia in vitro. Phytomedicine: Int J Phytotherapy Phytopharmacology. 2018;40:10–9.CrossRef
20.
Khalid M, Hassani D, Bilal M, Butt ZA, Hamayun M, Ahmad A, Huang D, Hussain A. Identification of oral cavity biofilm forming bacteria and determination of their growth inhibition by Acacia arabica, Tamarix aphylla L. and Melia azedarach L. medicinal plants. Arch Oral Biol. 2017;81:175–85.PubMedCrossRef
21.
Benmerache A, Benteldjoune M, Alabdul Magid A, Abedini A, Berrehal D, Kabouche A, Gangloff SC, Voutquenne-Nazabadioko L, Kabouche Z. Chemical composition, antioxidant and antibacterial activities of Tamarix balansae J. Gay aerial parts. Nat Prod Res. 2017;31(24):2828–35.PubMedCrossRef
22.
Qadir M, Abbas K, Hamayun R, Ali M. Analgesic, anti-inflammatory and anti-pyretic activities of aqueous ethanolic extract of Tamarix aphylla L. (Saltcedar) in mice. Pak J Pharm Sci. 2014;27 6:1985–8.
23.
Bettaib J, Talarmin H, Droguet M, Magné C, Boulaaba M, Giroux-Metges MA, Ksouri R. Tamarix gallica phenolics protect IEC-6 cells against H(2)O(2) induced stress by restricting oxidative injuries and MAPKs signaling pathways. Biomed Pharmacother. 2017;89:490–8.CrossRef
24.
Xing Y, Liao J, Tang Y, Zhang P, Tan C, Ni H, Wu X, Li N, Jia X. ACE and platelet aggregation inhibitors from Tamarix hohenackeri Bunge (host plant of Herba Cistanches) growing in Xinjiang. Pharmacognosy Magazine. 2014;10(38):111–7.PubMedPubMedCentralCrossRef
25.
Yao Y, Jiang CS, Sun N, Li WQ, Niu Y, Han HQ, Miao ZH, Zhao XX, Zhao J, Li J. Tamaractam, a New Bioactive Lactam from Tamarix ramosissima, Induces Apoptosis in Rheumatoid Arthritis Fibroblast-Like Synoviocytes. Molecules. 2017;22(1).
26.
Abaza MS, Al-Attiyah R, Bhardwaj R, Abbadi G, Koyippally M, Afzal M. Syringic acid from Tamarix aucheriana possesses antimitogenic and chemo-sensitizing activities in human colorectal cancer cells. Pharm Biol. 2013;51(9):1110–24.PubMedCrossRef
27.
Komal S, Malik A, Akhtar N, Kazmi S, Anjum F, Rida A. Tamarix dioica (Ghaz) Protective Potential in the Carbon Tetrachloride-Induced Hepatotoxicity Animal Model. 2021;35:37–43.
28.
Ali SAS, Ahmad S, Ali M, Ahsan W, Siddiqui MR, Ansari S, Shamim S, Ali MD. Wound Healing Activity of Alcoholic Extract of Tamarix Aphylla L. on Animal Models. Biomed Pharmacol J. 2019;12(1).
29.
Abdelgawad A. Tamarix nilotica (Ehrenb) Bunge: A Review of Phytochemistry and Pharmacology. J Microb Biochem Technol. 2017;09.
30.
Sekkien A, Swilam N, Ebada SS, Esmat A, El-Khatib AH, Linscheid MW, Singab AN. Polyphenols from Tamarix nilotica: LC-ESI-MS(n) Profiling and In Vivo Antifibrotic Activity. Molecules. 2018;23(6).
31.
Riham OB, Mohamed AE-AER, Rehab SA. Phenolic content, radical scavenging activity and cytotoxicity of Tamarix nilotica (Ehrenb.) bunge growing in Egypt. J Pharmacognosy Phytotherapy. 2013;5(3):47–52.CrossRef
32.
Ali M, Alhazmi H, Ansari S, Hussain A, Ahmad S, Alam M, Ali M, El-Sharkawy K, Hakeem K. Tamarix aphylla (L.) Karst. Phytochemical and Bioactive Profile Compilations of Less Discussed but Effective Naturally Growing Saudi Plant: Pharmacology and Therapeutic Uses. In., edn.; 2019: 343–52.
33.
Sobeai S, ANTICANCER, CYTOTOXIC EFFECT OF TAMARIX APHYLLA, AND ANTIBACTERIAL SCREENING EFFICIENCY AGAINST MULTIDRUG-RESISTANT HUMAN PATHOGENS. Asian J Pharm Clin Res. 2018;11:241.CrossRef
34.
Mahfoudhi A, Prencipe FP, Mighri Z, Pellati F. Metabolite profiling of polyphenols in the tunisian plant Tamarix aphylla (L.) Karst. J Pharm Biomed Anal. 2014;99:97–105.PubMedCrossRef
35.
Akhlaq M, Mohammed A. New phenolic acids from the galls of Tamarix aphylla (L.) Karst. Int Res J Pharm. 2011;4:222–5.
36.
Abdel-Tawab FM, Shebl SA, Al-Senosy NK, Abdou HS. Assessment of anticancerogenic effect of Tamarix nilotica on human lung cancer cell line. Egypt J Genet Cytol 2019;48.
37.
Bakr RO, Raey MAE, Ashour RMS. Phenolic content, radical scavenging activity and cytotoxicity of Tamarix nilotica (Ehrenb.) bunge growing in Egypt. J Pharmacognosy Phytotherapy. 2013;5:47–52.CrossRef
38.
Abouzid S, Sleem A. Hepatoprotective and antioxidant activities of Tamarix nilotica flowers. Pharm Biol. 2011;49(4):392–5.PubMedCrossRef
39.
Bakr RO, Fayed MAA, Fayez AM, Gabr SK, El-Fishawy AM, Taha SE-A. Hepatoprotective activity of Erythrina × neillii leaf extract and characterization of its phytoconstituents. Phytomedicine: Int J Phytother Phytopharmacol. 2019;53:9–17.CrossRef
40.
Amr A, Abd El-Wahed A, El-Seedi HR, Khalifa SAM, Augustyniak M, El-Samad LM, Abdel Karim AE, El Wakil A. UPLC-MS/MS Analysis of Naturally Derived Apis mellifera Products and Their Promising Effects against Cadmium-Induced Adverse Effects in Female Rats. Nutrients. 2022;15(1).
41.
Azeem HHA, Osman GY, El-Seedi HR, Fallatah AM, Khalifa SAM, Gharib MM. Antifungal Activity of Soft Tissue Extract from the Garden Snail Helix aspersa (Gastropoda, Mollusca). Molecules. 2022;27(10).
42.
Darwish AMG, Abd El-Wahed AA, Shehata MG, El-Seedi HR, Masry SHD, Khalifa SAM, Mahfouz HM, El-Sohaimy SA. Chemical Profiling and Nutritional Evaluation of Bee Pollen, Bee Bread, and Royal Jelly and Their Role in Functional Fermented Dairy Products. Molecules. 2022;28(1).
43.
El-Din MIG, Fahmy NM, Wu F, Salem MM, Khattab OM, El-Seedi HR, Korinek M, Hwang T-L, Osman AK, El-Shazly M. Comparative LC–LTQ–MS–MS analysis of the Leaf extracts of Lantana camara and Lantana montevidensis growing in Egypt with Insights into their Antioxidant, anti-inflammatory, and cytotoxic activities. Plants. 2022;11(13):1699.PubMedPubMedCentralCrossRef
44.
El-Garawani IM, Abd El-Gaber AS, Algamdi NA, Saeed A, Zhao C, Khattab OM, AlAjmi MF, Guo Z, Khalifa SAM, El-Seedi HR. In Vitro induction of apoptosis in isolated Acute myeloid leukemia cells: the role of Anastatica hierochuntica Methanolic Extract. Metabolites. 2022;12(9):878.PubMedPubMedCentralCrossRef
45.
Dawod A, Fathalla SI, Elkhatam A, Osman N, Sheraiba N, Hammad MA, El-Seedi HR, Shehata AA, Anis A. UPLC-QToF nanospray MS and NMR analysis of Ficus sycomorus Stem Bark and its Effects on rabbit. Processes. 2021;9(7):1201.CrossRef
46.
Basiouni S, Fayed MAA, Tarabees R, El-Sayed M, Elkhatam A, Töllner KR, Hessel M, Geisberger T, Huber C, Eisenreich W, et al. Characterization of sunflower oil extracts from the lichen usnea barbata. Metabolites. 2020;10(9):1–16.CrossRef
47.
Vichai V, Kirtikara K. Sulforhodamine B colorimetric assay for cytotoxicity screening. Nat Protoc. 2006;1(3):1112–6.PubMedCrossRef
48.
Kamiloglu S, Sari G, Ozdal T, Capanoglu E. Guidelines for cell viability assays. Food Front. 2020;1(3):332–49.CrossRef
49.
Bakr RO, El-Behairy MF, Elissawy AM, Elimam H, Fayed MAA. New adenosine derivatives from Aizoon canariense L.: In vitro anticholinesterase, antimicrobial, and cytotoxic evaluation of its extracts. Molecules. 2021;26(5).
50.
Roy M, Chakraborty S, Mali K, Chatterjee S, Banerjee S, Mitra S, Naskar R, Bhattacharjee A. Cellular image processing using morphological analysis. In: 2017 IEEE 8th Annual Ubiquitous Computing, Electronics and Mobile Communication Conference (UEMCON): 19–21 Oct 2017 2017; 2017: 237–241.
51.
Abdou EM, Fayed MAA, Helal D, Ahmed KA. Assessment of the hepatoprotective effect of developed lipid-polymer hybrid nanoparticles (LPHNPs) encapsulating naturally extracted β-Sitosterol against CCl4 induced hepatotoxicity in rats. Sci Rep. 2019;9(1):19779.PubMedPubMedCentralCrossRef
52.
Chernonosov AA, Karpova EA, Lyakh EM. Identification of phenolic compounds in Myricaria bracteata leaves by high-performance liquid chromatography with a diode array detector and liquid chromatography with tandem mass spectrometry. Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy. 2017;27:576–9.CrossRef
53.
Iskhanov Y. Chemical compositional analysis of the Tamarix hispida aerial part extract obtained in ethanol solutions of different concentration. J Appl Eng Sci. 2018;16:233–41.CrossRef
54.
Nawwar MAM, El-Sissi HI, Barakat HH. Flavonoid constituents of Ephedra alata. Phytochemistry. 1984;23:2937–9.CrossRef
55.
Ren X, Wang W, Bao Y, Zhu Y, Zhang Y, Lu Y, Peng Z, Zhou G. Isorhamnetin and Hispidulin from Tamarix ramosissima Inhibit 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine (PhIP) Formation by Trapping Phenylacetaldehyde as a Key Mechanism. Foods (Basel Switzerland). 2020;9(4).
56.
Orabi MA, Taniguchi S, Hatano T. Monomeric and dimeric hydrolysable tannins of Tamarix nilotica. Phytochemistry. 2009;70(10):1286–93.PubMedCrossRef
57.
Lefahal M, Benahmed M, Louaar S, Zellagui A, Duddeck H, Kamel M, Akkal S. Antimicrobial activity of Tamarix gallica L. extracts and isolated flavonoids. Adv Nat Appl Sci. 2010;4:289–92.
58.
Sharifi-Rad J, Song S, Ali A, Subbiah V, Taheri Y, Suleria HAR. LC-ESI-QTOF-MS/MS characterization of phenolic compounds from Pyracantha coccinea M.Roem. and their antioxidant capacity. Cell Mole Biol (Noisy-le-Grand, France). 2021;67(1):201–211.
59.
Tomás-Barberán FA, Iniesta-Sanmartín E, Tomás-Lorente F, Rumbero Á. Antimicrobial phenolic compounds from three spanish Helichrysum species. Phytochemistry. 1990;29:1093–5.CrossRef
60.
Hooi Poay T, Sui Kiong L, Cheng Hock C. Characterisation of Galloylated Cyanogenic Glucosides and Hydrolysable Tannins from Leaves of Phyllagathis rotundifolia by LC-ESI-MS/MS. Phytochem Anal. 2011;22(6):516–25.PubMedCrossRef
61.
Orabi MA, Taniguchi S, Yoshimura M, Yoshida T, Hatanoa T. New monomeric and dimeric hydrolyzable tannins from Tamarix nilotica. Heterocycles. 2010;80(1):463–75.CrossRef
62.
AbouZid SF, Ali S, Choudhary MI. A new ferulic acid ester and other constituents from Tamarix nilotica leaves. Chem Pharm Bull. 2009;57 7:740–2.CrossRef
63.
Yoshida T, Ahmed A, Memon M, Okuda T. Tannins of tamaricaceous plants II. New Monomeric and Dimeric Hydrolyzable Tannins from Reaumuria hirtella and Tamarix pakistanica. Chem Pharm Bull. 1991;39:2849–54.CrossRef
64.
Orabi MAA, Taniguchi S, Sakagami H, Yoshimura M, Yoshida T, Hatano T. Hydrolyzable Tannins of Tamaricaceous plants. V. Structures of Monomeric–Trimeric Tannins and cytotoxicity of macrocyclic-type tannins isolated from Tamarix nilotica. J Nat Prod. 2013;76(5):947–56.PubMedCrossRef
65.
Sanz M, de Simón BF, Cadahía E, Esteruelas E, Muñoz AM, Hernández T, Estrella I, Pinto E. LC-DAD/ESI-MS/MS study of phenolic compounds in ash (Fraxinus excelsior L. and F. americana L.) heartwood. Effect of toasting intensity at cooperage. J mass spectrometry: JMS. 2012;47(7):905–18.PubMedCrossRef
66.
Orabi MAA, Zidan SAH, Attia GH, Alyami HS, Matsunami K, Hatano T. Ellagitannins and simple phenolics from the halophytic plant Tamarix nilotica. Nat Prod Res. 2022;36(1):177–85.PubMedCrossRef
67.
Yoshida T, Hatano T, Ahmed AF, Okonogi A, Okuda T. Structures of isorugosin E and hirtellin B, dimeric hydrolyzable tannins having a trisgalloyl group. Tetrahedron. 1991;47(22):3575–84.CrossRef
68.
Orabi MAA, Taniguchi S, Yoshimura M, Yoshida T, Kishino K, Sakagami H, Hatano T. Hydrolyzable Tannins of Tamaricaceous plants. III. Hellinoyl- and macrocyclic-type ellagitannins from Tamarix nilotica. J Nat Prod. 2010;73(5):870–9.PubMedCrossRef
69.
Thambugala KM, Daranagama DA, Phillips AJL, Bulgakov TS, Bhat DJ, Camporesi E, Bahkali AH, Eungwanichayapant PD, Liu Z-Y, Hyde KD. Microfungi on Tamarix. Fungal Divers. 2017;82(1):239–306.CrossRef
70.
Hatano T, Orabi M, Taniguchi S, Yoshida T, Yoshimura M. New Monomeric and Dimeric Hydrolyzable Tannins from Tamarix nilotica. Heterocycles 2010, 80.
71.
Francescato LN, Debenedetti SL, Schwanz TG, Bassani VL, Henriques AT. Identification of phenolic compounds in Equisetum giganteum by LC-ESI-MS/MS and a new approach to total flavonoid quantification. Talanta. 2013;105:192–203.PubMedCrossRef
72.
Nawwar MAM, Souleman AMA, Buddrus J, Linscheid M. Flavonoids of the flowers of Tamarix nilotica. Phytochemistry. 1984;23(10):2347–9.CrossRef
73.
Bakr RO, Amer RI, Fayed MAA, Ragab TIM. A Completely Polyherbal Conditioning and Antioxidant Shampoo: A Phytochemical Study and Pharmaceutical Evaluation. J Pharm Bioallied Sci. 2019;11(2).
74.
Abdul Khaliq H, Ortiz S, Alhouayek M, Muccioli GG, Quetin-Leclercq J. Dereplication and Quantification of Major Compounds of Convolvulus arvensis L. Extracts and Assessment of Their Effect on LPS-Activated J774 Macrophages. Molecules. 2022;27(3).
75.
el-Mousallami A, Hussein S, Nawwar M. Polyphenolic metabolites of the flowers of Tamarix tetragyna. Nat Prod Sci. 2000;6:193–8.
76.
Jenkinson SF, Cowley A, Kato A, Kato N, Hollinshead J, Nash RJ, Booth KV, Fleet GWJ. (2R, 3S)-3-Hydroxy-N, N-dimethylproline monohydrate. Acta Crystallogr Sect E: Struct Rep Online. 2007;63(9):o3717–7.CrossRef
77.
Nawwar MAM, Souleman AMA. 3, 4, 8, 9, 10-Pentahydroxy-dibenzo [b, d] pyran-6-one from Tamarix nilotica. Phytochemistry. 1984;23(12):2966–7.CrossRef
78.
Abouzid SF, Ali SA, Choudhary MI. A new ferulic acid ester and other constituents from Tamarix nilotica leaves. Chem Pharm Bull. 2009;57(7):740–2.CrossRef
79.
Mahrous FSM, Mohammed H, Sabour R. LC-ESI-QTOF-MS/MS of Holoptelea integrifolia (Roxb.) Planch. Leaves and in silico study of phenolic compounds’ antiviral activity against the HSV1 virus. Azhar Int J Pharm Med Sci. 2021;1(3):91–101.CrossRef
80.
Sekkien A, Swilam N, Ebada SS, Esmat A, El-Khatib AH, Linscheid MW, Singab AN. Polyphenols from Tamarix nilotica: LC–ESI-MSn profiling and in vivo antifibrotic activity. Molecules. 2018;23(6):1411.PubMedPubMedCentralCrossRef
81.
Dang Y, Lin G, Xie Y, Duan J, Ma P, Li G, Ji G. Quantitative determination of myricetin in rat plasma by ultra performance liquid chromatography tandem mass spectrometry and its absolute bioavailability. Drug Res. 2014;64(10):516–22.
82.
Boulaaba M, Tsolmon S, Ksouri R, Han J, Kawada K, Smaoui A, Abdelly C, Isoda H. Anticancer effect of Tamarix gallica extracts on human colon cancer cells involves Erk1/2 and p38 action on G2/M cell cycle arrest. Cytotechnology. 2013;65(6):927–36.PubMedPubMedCentralCrossRef
83.
Stevens JF, Wollenweber E, Ivancic M, Hsu VL, Sundberg S, Deinzer ML. Leaf surface flavonoids of Chrysothamnus. Phytochemistry. 1999;51(6):771–80.CrossRef
84.
Parmalr VS, Rathore JS, Singh S, Jain AK, Gupta SR. Troupin, a 4-methylcoumarin from Tamarix troupii. Phytochemistry. 1985;24(4):871–2.CrossRef
85.
Riham O, Bakr AT, Heba A, El-Gizawy N, Tawfik UR, Abdelmohsen, Miada F, Abdelwahab WA, Alshareef SM, Fayez, Shereen MS, El-Mancy AM, El-Fishawy MA. Abdelkawy and Marwa A. A. Fayed: The metabolomic analysis of five Mentha species: cytotoxicity, anti-Helicobacter assessment, and the development of polymeric micelles for enhancing the anti-Helicobacter activity. 2021.
86.
Karker M, De Tommasi N, Smaoui A, Abdelly C, Ksouri R, Braca A. New sulphated flavonoids from Tamarix africana and biological activities of its polar extract. Planta Med. 2016;82(15):1374–80.PubMedCrossRef
87.
Abad-García B, Garmón‐Lobato S, Berrueta LA, Gallo B, Vicente F. A fragmentation study of dihydroquercetin using triple quadrupole mass spectrometry and its application for identification of dihydroflavonols in Citrus juices. Rapid Commun Mass Spectrometry: Int J Devoted Rapid Dissemination Up‐to‐the‐Minute Res Mass Spectrom. 2009;23(17):2785–92.CrossRef
88.
Dalia I, Hamdan MAAF, Adel R. Echinops taeckholmiana Amin: optimization of a tissue culture protocol, Biological evaluation, and Chemical Profiling using GC and LC-MS. ACS Omega. 2021;6(20):13105–15.CrossRef
89.
Xiang D, Fan L, Hou Xl, Xiong W, Shi, Cy. Wang Wq, Fang Jg: uptake and transport mechanism of Dihydromyricetin Across Human intestinal Caco-2 cells. J Food Sci. 2018;83(7):1941–7.PubMedCrossRef
90.
Fayed MAA, Abouelela ME, Refaey MS. Heliotropium ramosissimum metabolic profiling, in silico and in vitro evaluation with potent selective cytotoxicity against colorectal carcinoma. Sci Rep. 2022;12:12539.PubMedPubMedCentralCrossRef
91.
Kim HK, Choi YH, Verpoorte R. NMR-based plant metabolomics: where do we stand, where do we go? Trends Biotechnol. 2011;29(6):267–75.PubMedCrossRef
92.
Alnuqaydan AM, Rah B. Tamarix articulata inhibits cell proliferation, promotes cell death mechanisms and triggers G(0)/G(1) cell cycle arrest in Hepatocellular Carcinoma cells. Food Technol Biotechnol. 2021;59(2):162–73.PubMedPubMedCentralCrossRef
93.
Abdullah MA, Abdulmajeed GA, Ohoud YA, Hanan Ali H, Abdullah MA, Abdullah A, Abdullah A, Mohd Younis R, Bilal R. Evaluation of the cytotoxic activity of Tamarix articulata and its anticancer potential in prostate cancer cells. J Appl Pharm Sci. 2022.
94.
Hassan LEA, Ahamed MBK, Majid ASA, Baharetha HM, Muslim NS, Nassar ZD, Majid AMSA. Correlation of antiangiogenic, antioxidant and cytotoxic activities of some sudanese medicinal plants with phenolic and flavonoid contents. BMC Complement Altern Med. 2014;14(1):406.PubMedPubMedCentralCrossRef
95.
Umbetova AK, Choudhary MI, Sultanova NA, Burasheva GS, Abilov ZA. Flavonoids of plants from the Genus Tamarix. Chem Nat Compd. 2004;41:728–9.CrossRef
96.
Orabi MA, Taniguchi S, Terabayashi S, Hatano T. Hydrolyzable tannins of tamaricaceous plants. IV: Micropropagation and ellagitannin production in shoot cultures of Tamarix tetrandra. Phytochemistry. 2011;72(16):1978–89.PubMedCrossRef
97.
Rezaei-Seresht H, Cheshomi H, Falanji F, Movahedi-Motlagh F, Hashemian M, Mireskandari E. Cytotoxic activity of caffeic acid and gallic acid against MCF-7 human breast cancer cells: an in silico and in vitro study. Avicenna J Phytomedicine. 2019;9(6):574–86.
98.
El Khazendar M, Chalak J, El-Huneidi W, Vinod A, Abdel-Rahman W, Abu-Gharbieh E. Antiproliferative and proapoptotic activities of ferulic acid in breast and liver cancer cell lines. 2019.
99.
Nawwar MA, Youb NA, El-Raey MA, Zaghloul SS, Hashem AM, Mostafa ES, Eldahshan O, Werner V, Becker A, Haertel B, et al. Polyphenols in Ammania auriculata: structures, antioxidative activity and cytotoxicity. Die Pharmazie Int J Pharmaceut Sci. 2014;69(11):860–4.
100.
Han M, Gao H, Xie J, Yuan YP, Yuan Q, Gao MQ, Liu KL, Chen XH, Han YT, Han ZW. Hispidulin induces ER stress-mediated apoptosis in human hepatocellular carcinoma cells in vitro and in vivo by activating AMPK signaling pathway. Acta Pharmacol Sin. 2019;40(5):666–76.PubMedCrossRef
101.
Lv L, Zhang W, Li T, Jiang L, Lu X, Lin J. Hispidulin exhibits potent anticancer activity in vitro and in vivo through activating ER stress in non–small–cell lung cancer cells. Oncol Rep. 2020;43(6):1995–2003.PubMedPubMedCentral
102.
Bhasker S, Madhav H, Chinnamma M. Molecular evidence of insulinomimetic property exhibited by steviol and stevioside in diabetes induced L6 and 3T3L1 cells. Phytomedicine Int J Phytother Phytopharmacol. 2015;22(11):1037–44.CrossRef
103.
Xu H, Yang T, Liu X, Tian Y, Chen X, Yuan R, Su S, Lin X, Du G. Luteolin synergizes the antitumor effects of 5-fluorouracil against human hepatocellular carcinoma cells through apoptosis induction and metabolism. Life Sci. 2016;144:138–47.PubMedCrossRef
104.
Han K, Meng W, Zhang JJ, Zhou Y, Wang YL, Su Y, Lin SC, Gan ZH, Sun YN, Min DL. Luteolin inhibited proliferation and induced apoptosis of prostate cancer cells through miR-301. OncoTargets Therapy. 2016;9:3085–94.PubMedPubMedCentralCrossRef
105.
Sato Y, Sasaki N, Saito M, Endo N, Kugawa F, Ueno A. Luteolin attenuates doxorubicin-induced cytotoxicity to MCF-7 human breast cancer cells. Biol Pharm Bull. 2015;38(5):703–9.PubMedCrossRef
106.
Li SZ, Li K, Zhang JH, Dong Z. The effect of quercetin on doxorubicin cytotoxicity in human breast cancer cells. Anti-cancer Agents Med Chem. 2013;13(2):352–5.CrossRef
107.
Maurya AK, Vinayak M. Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line. Mol Biol Rep. 2015;42(9):1419–29.PubMedCrossRef
Metadata
Title
Chemical profiling and cytotoxic potential of the n-butanol fraction of Tamarix nilotica flowers
Authors
Marwa A. A. Fayed
Riham O. Bakr
Nermeen Yosri
Shaden A. M. Khalifa
Hesham R. El-Seedi
Dalia I. Hamdan
Mohamed S. Refaey
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2023
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-023-03989-8

Other articles of this Issue 1/2023

BMC Complementary Medicine and Therapies 1/2023 Go to the issue

Study Protocol

Efficacy and safety of self-administered acupressure on symptoms, quality of life and nasal mucosal function in patients with perennial allergic rhinitis: study protocol for a randomized controlled exploratory trial

Research

Adherence to lifestyle recommendations among Norwegian cancer survivors and the impact of traditional and complementary medicine use: the Tromsø Study 2015–2016

Research

Machine learning classification of polycystic ovary syndrome based on radial pulse wave analysis

Study Protocol

Multiform-based Baduanjin exercise prevention and treatment for idiopathic pulmonary fibrosis: study protocol for a randomized controlled trial

Research

Gut microbiota mediated the therapeutic efficiency of Simiao decoction in the treatment of gout arthritis mice

Research

Allopathic Medicine Practitioners’ perspectives on facilitating disclosure of traditional medicine use in Gauteng, South Africa: a qualitative study