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BMC Cancer
Published in: BMC Cancer 1/2006

Open Access 01-12-2006 | Research article

CHEK2 1100delC in patients with metachronous cancers of the breast and the colorectum

Authors: Anna Isinger, Misha Bhat, Ake Borg, Mef Nilbert

Published in: BMC Cancer | Issue 1/2006

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Abstract

Background

Development of multiple primary tumors is a hallmark of hereditary cancer. At least 1/10 of breast cancers and colorectal cancers occur because of heredity and recently the cell cycle kinase 2, CHEK2 1100delC allele has been identified at a particularly high frequency in families with hereditary breast and colorectal cancer.

Methods

We utilized the Southern Sweden population-based cancer registry to identify women with double primary breast and colorectal cancer and sequenced tumor material in order to assess the contribution of the CHEK2 1100delC to the development of such metachronous tumors.

Results

Among the 75 patients successfully analyzed, 2 (2.5%) carried the CHEK2 1100delC allele. which was not significantly different (p = 0.26) from the 1% (3/300) carriers identified in the control group.

Conclusion

In summary, our data suggest that the CHEK2 1100delC is not a major cause of double primary breast and colorectal cancer in Sweden, which suggests that this patient group should not routinely be screened for the CHEK2 1100delC variant.
Appendix
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Metadata
Title
CHEK2 1100delC in patients with metachronous cancers of the breast and the colorectum
Authors
Anna Isinger
Misha Bhat
Ake Borg
Mef Nilbert
Publication date
01-12-2006
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2006
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-6-64

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