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01-09-2016 | Original Article

Charlson comorbidity index as a predictor of in-hospital death in acute ischemic stroke among very old patients: a single-cohort perspective study

Authors: Lorenzo Falsetti, Giovanna Viticchi, Nicola Tarquinio, Mauro Silvestrini, William Capeci, Vania Catozzo, Agnese Fioranelli, Laura Buratti, Francesco Pellegrini

Published in: Neurological Sciences | Issue 9/2016

Abstract

Chronic diseases are increasing worldwide. Association of two or more chronic conditions is related with poor health status and reduced life expectancy, particularly among elderly patients. Comorbidities represent a risk factor for adverse events in several critical illnesses. We aimed to evaluate if elderly patients are affected by multiple chronic pathologies, assessed by Charlson comorbidity index (CCI), showed a reduced in-hospital survival after ischemic stroke. In a 3-year period, we evaluated all the subjects admitted to our internal medicine department for ischemic stroke. Age, sex, NIHSS score and all the comorbidities were recorded. Days of hospitalization, hospital-related infections and in-hospital mortality were also assessed. For each patient, we evaluated CCI, obtaining four classes: group 1 (CCI: 2–3), group 2 (CCI: 4–5), group 3 (CCI: 6–7) and group 4 (CCI: ≥8). Survival was evaluated with Kaplan–Meier and Cox regression analyses. The complete model considered in-hospital death as the main outcome, days of hospitalization as the time variable and CCI as the main predictor, adjusting for NIHSS, sex and nosocomial infections. Patients in CCI group 3 and 4 had an increased risk of in-hospital mortality, independently of NIHSS, sex and nosocomial infections. Elderly patients with multiple comorbidities have higher risk of in-hospital death when affected by ischemic stroke.

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Title: Charlson comorbidity index as a predictor of in-hospital death in acute ischemic stroke among very old patients: a single-cohort perspective study
Authors: Lorenzo Falsetti
Giovanna Viticchi
Nicola Tarquinio
Mauro Silvestrini
William Capeci
Vania Catozzo
Agnese Fioranelli
Laura Buratti
Francesco Pellegrini
Publication date: 01-09-2016
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 9/2016
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-016-2602-1

At a glance: The STEP trials

Springer Medicine

Charlson comorbidity index as a predictor of in-hospital death in acute ischemic stroke among very old patients: a single-cohort perspective study

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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