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International Journal of Colorectal Disease

Published in:

01-01-2010 | Original Article

Characterization of special propulsive contractions during rectal evacuation in a canine model of intestinal extrinsic denervation and rectal transection

Authors: Yuichi Tabe, Erito Mochiki, Mitsuhiro Yanai, Yoshitaka Toyomasu, Hiroyuki Ando, Tetsuro Ohno, Hayato Yamauchi, Takaharu Fukasawa, Satoru Yamaguchi, Soichi Tsutsumi, Takayuki Asao, Hiroyuki Kuwano

Published in: International Journal of Colorectal Disease | Issue 1/2010

Abstract

Purpose

The mechanism for the initiation of giant migrating contractions (GMCs) associated with defecation is not well known. The aim of this study was to describe the characteristics of special propulsive contractions (SPCs), such as GMCs, during evacuation in four experimental dog models, with emphasis on denervation.

Materials and methods

Twenty healthy dogs were used in this study, and they were divided into four groups, i.e., control (underwent force transducer implantation alone), denervation (underwent transection of the descending nerve fibers along the caudal mesenteric artery (CMA)), transection (underwent transection of the rectum, which corresponds to transection of the enteric nerve fibers), and denervation-plus-transection (underwent transection of the descending nerve fibers along the CMA and transection of the rectum). Colonic contractile activities were continuously recorded on a computer. Five force transducers were implanted at the serosal surfaces of the colon (C1-R). The consistency of dog feces was checked daily. The parameters of rectal relaxation (RR), defecation characteristics, and SPCs, such as motility index (MI), duration, and frequency, were measured.

Results

In the control and denervation groups, GMCs were observed with evacuation, and RR occurred synchronously with the initiation of GMCs. On the other hand, in the transection and denervation-plus-transection groups, strong force contractions without RR occurred only during evacuation. The MI and duration of the transection and denervation-plus-transection groups were higher than those of other groups (p < 0.05). The frequency of SPCs was the highest in the denervation-plus-transection group.

Conclusions

In conclusion, the continuity of enteric nerves is necessary for the occurrence of GMCs and rectal relaxation (RR).

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Title: Characterization of special propulsive contractions during rectal evacuation in a canine model of intestinal extrinsic denervation and rectal transection
Authors: Yuichi Tabe
Erito Mochiki
Mitsuhiro Yanai
Yoshitaka Toyomasu
Hiroyuki Ando
Tetsuro Ohno
Hayato Yamauchi
Takaharu Fukasawa
Satoru Yamaguchi
Soichi Tsutsumi
Takayuki Asao
Hiroyuki Kuwano
Publication date: 01-01-2010
Publisher: Springer-Verlag
Published in: International Journal of Colorectal Disease / Issue 1/2010
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-009-0799-7

2024 ASCO Annual Meeting

Springer Medicine

Characterization of special propulsive contractions during rectal evacuation in a canine model of intestinal extrinsic denervation and rectal transection

Abstract

Purpose

Materials and methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusions

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