Published in:
Open Access
01-12-2010 | Short report
Characterization of leukotrienes in a pilot study of older asthma subjects
Authors:
Sharmilee M Nyenhuis, Elizabeth A Schwantes, Sameer K Mathur
Published in:
Immunity & Ageing
|
Issue 1/2010
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Excerpt
Asthma is a chronic inflammatory disorder of the lower airway that results in mucus secretion, airway edema and reversible airway obstruction [
1]. These characteristic features lead to the clinical symptoms of asthma, which include recurrent episodes of wheezing, breathlessness, chest tightness and coughing [
2]. The pathophysiology of asthma is not fully elucidated but the current paradigm involves multiple cell types (ie. eosinophils, neutrophils, mast cells, T-cells) and their mediators. …