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Langenbeck's Archives of Surgery

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01-09-2008 | Original Article

Characteristics of well-differentiated thyroid cancer associated with multinodular goiter

Authors: Shih-Ping Cheng, Chien-Liang Liu, Chi-Yuan Tzen, Tsen-Long Yang, Kuo-Shyang Jeng, Tsang-Pai Liu, Jie-Jen Lee

Published in: Langenbeck's Archives of Surgery | Issue 5/2008

Abstract

Background

The likelihood of thyroid cancer is similar in patients with one or more nodules, but tumor characteristics of thyroid cancer in glands with multinodular goiter are unclear.

Materials and methods

This study consisted of 100 consecutive patients (ages 15–81 years; 84 women), who underwent thyroidectomy for papillary or follicular thyroid carcinoma between 2005 and 2006. Patient demographics, diagnostic tests, operations, and pathological findings were reviewed.

Results

In a univariate analysis, cancer diagnosed within multinodular goiter was different from solitary cancer nodule in age of diagnosis (48 vs 40 years, p = 0.002), tumor size (1.42 vs 2.20 cm, p = 0.024), and the presence of cervical lymph node metastases (p = 0.035). There was no difference in gender, extrathyroidal invasion, multifocality, and types of operation. Only age (odds ratio, 1.056) and tumor size (odds ratio, 0.730) revealed independent correlation in multivariate analysis.

Conclusion

Thyroid cancer in glands with multiple nodules is associated with older age at diagnosis and smaller tumor size.

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Title: Characteristics of well-differentiated thyroid cancer associated with multinodular goiter
Authors: Shih-Ping Cheng
Chien-Liang Liu
Chi-Yuan Tzen
Tsen-Long Yang
Kuo-Shyang Jeng
Tsang-Pai Liu
Jie-Jen Lee
Publication date: 01-09-2008
Publisher: Springer-Verlag
Published in: Langenbeck's Archives of Surgery / Issue 5/2008
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-008-0327-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Characteristics of well-differentiated thyroid cancer associated with multinodular goiter

Abstract

Background

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Materials and methods

Results

Conclusion

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