Skip to main content
Top
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 4/2017

01-04-2017 | Retinal Disorders

Characteristics of cases with postoperative vitreous hemorrhage after 25-gauge vitrectomy for repair of proliferative diabetic retinopathy

Authors: Tatsuhiko Sato, Kotaro Tsuboi, Hiroshi Nakashima, Kazuyuki Emi

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 4/2017

Login to get access

Abstract

Purpose

The purpose of this study was to compare ocular and systemic parameters between proliferative diabetic retinopathy (PDR) cases with postoperative vitreous hemorrhage (PVH) and those without PVH after 25-gauge vitrectomy, and to investigate the predictors of PVH.

Methods

The medical records of 106 eyes of 78 consecutive patients who underwent primary 25-gauge vitrectomy were reviewed.

Results

The incidences of early and late PVH were found to be 18.9 % (20/106 eyes) and 17.9 % (19/106 eyes) respectively. On multiple logistic regression analysis, intraoperative bleeding from new vessels on the disc was identified as the most important factor, with the greatest odds ratio, for the development of early PVH (odds ratio = 3.395, P = 0.134), while the HbA1c level was identified as the most important significant factor, with the greatest odds ratio, for the development of late PVH (odds ratio = 1.403, P = 0.014).

Conclusions

Early PVH tends to occur in severe PDR cases, while late PVH tends to occur in cases with poor diabetic control.
Literature
1.
go back to reference Congdon NG, Friedman DS, Lietman T (2003) Important causes of visual impairment in the world today. JAMA 290:2057–2060CrossRefPubMed Congdon NG, Friedman DS, Lietman T (2003) Important causes of visual impairment in the world today. JAMA 290:2057–2060CrossRefPubMed
3.
go back to reference Fujii GY, De Juan E Jr, Humayun MS, Pieramici DJ, Chang TS, Awh C, Ng E, Barnes A, Wu SL, Sommerville DN (2002) A new 25-gauge instrument system for transconjunctival sutureless vitrectomy surgery. Ophthalmology 109:1807–1812CrossRefPubMed Fujii GY, De Juan E Jr, Humayun MS, Pieramici DJ, Chang TS, Awh C, Ng E, Barnes A, Wu SL, Sommerville DN (2002) A new 25-gauge instrument system for transconjunctival sutureless vitrectomy surgery. Ophthalmology 109:1807–1812CrossRefPubMed
4.
go back to reference Lai MM, Ruby AJ, Sarrafizadeh R, Urban KE, Hassan TS, Drenser KA, Garretson BR (2008) Repair of primary rhegmatogenous retinal detachment using 25-gauge transconjunctival sutureless vitrectomy. Retina 28:729–734CrossRefPubMed Lai MM, Ruby AJ, Sarrafizadeh R, Urban KE, Hassan TS, Drenser KA, Garretson BR (2008) Repair of primary rhegmatogenous retinal detachment using 25-gauge transconjunctival sutureless vitrectomy. Retina 28:729–734CrossRefPubMed
5.
go back to reference Mura M, Tan SH, De Smet MD (2009) Use of 25-gauge vitrectomy in the management of primary rhegmatogenous retinal detachment. Retina 29:1299–1304CrossRefPubMed Mura M, Tan SH, De Smet MD (2009) Use of 25-gauge vitrectomy in the management of primary rhegmatogenous retinal detachment. Retina 29:1299–1304CrossRefPubMed
6.
go back to reference Iwahashi-Shima C, Sato T, Bando H, Ikeda T, Emi K (2013) Anatomic and functional outcomes of 25-gauge vitrectomy for repair of eyes with rhegmatogenous retinal detachment complicated by proliferative vitreoretinopathy. Clin Ophthalmol 7:2043–2049PubMedPubMedCentral Iwahashi-Shima C, Sato T, Bando H, Ikeda T, Emi K (2013) Anatomic and functional outcomes of 25-gauge vitrectomy for repair of eyes with rhegmatogenous retinal detachment complicated by proliferative vitreoretinopathy. Clin Ophthalmol 7:2043–2049PubMedPubMedCentral
7.
go back to reference Sato T, Emi K, Bando H, Ikeda T (2014) Retrospective comparison of 25-gauge vitrectomy for repair of proliferative vitreoretinopathy with or without anterior proliferation. Graefes Arch Clin Exp Ophthalmol 252:1895–1902CrossRefPubMed Sato T, Emi K, Bando H, Ikeda T (2014) Retrospective comparison of 25-gauge vitrectomy for repair of proliferative vitreoretinopathy with or without anterior proliferation. Graefes Arch Clin Exp Ophthalmol 252:1895–1902CrossRefPubMed
8.
go back to reference Farouk MM, Naito T, Sayed KM, Nagasawa T, Katome T, Radwan G, Abdallah A, Elagouz M (2011) Outcomes of 25-gauge vitrectomy for proliferative diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 249:369–376CrossRefPubMed Farouk MM, Naito T, Sayed KM, Nagasawa T, Katome T, Radwan G, Abdallah A, Elagouz M (2011) Outcomes of 25-gauge vitrectomy for proliferative diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 249:369–376CrossRefPubMed
9.
go back to reference Schoenberger SD, Miller DM, Riemann CD, Foster RE, Sisk RA, Hutchins RK, Petersen MR (2011) Outcomes of 25-gauge pars plana vitrectomy in the surgical management of proliferative diabetic retinopathy. Ophthalmic Surg Lasers Imaging 42:474–480CrossRefPubMed Schoenberger SD, Miller DM, Riemann CD, Foster RE, Sisk RA, Hutchins RK, Petersen MR (2011) Outcomes of 25-gauge pars plana vitrectomy in the surgical management of proliferative diabetic retinopathy. Ophthalmic Surg Lasers Imaging 42:474–480CrossRefPubMed
10.
go back to reference Sato T, Emi K, Bando H, Ikeda T (2012) Faster recovery after 25-gauge microincision vitrectomy surgery than after 20-gauge vitrectomy in patients with proliferative diabetic retinopathy. Clin Ophthalmol 6:1925–1930CrossRefPubMedPubMedCentral Sato T, Emi K, Bando H, Ikeda T (2012) Faster recovery after 25-gauge microincision vitrectomy surgery than after 20-gauge vitrectomy in patients with proliferative diabetic retinopathy. Clin Ophthalmol 6:1925–1930CrossRefPubMedPubMedCentral
11.
go back to reference Lo WR, Kim SJ, Aaberg TM Sr, Bergstrom C, Srivastava SK, Yan J, Martin DF, Hubbard GB 3rd (2009) Visual outcomes and incidence of recurrent vitreous hemorrhage after vitrectomy in diabetic eyes pretreated with bevacizumab (avastin). Retina 29:926–931CrossRefPubMedPubMedCentral Lo WR, Kim SJ, Aaberg TM Sr, Bergstrom C, Srivastava SK, Yan J, Martin DF, Hubbard GB 3rd (2009) Visual outcomes and incidence of recurrent vitreous hemorrhage after vitrectomy in diabetic eyes pretreated with bevacizumab (avastin). Retina 29:926–931CrossRefPubMedPubMedCentral
12.
go back to reference Oshima Y, Shima C, Wakabayashi T, Kusaka S, Shiraga F, Ohji M, Tano Y (2009) Microincision vitrectomy surgery and intravitreal bevacizumab as a surgical adjunct to treat diabetic traction retinal detachment. Ophthalmology 116:927–938CrossRefPubMed Oshima Y, Shima C, Wakabayashi T, Kusaka S, Shiraga F, Ohji M, Tano Y (2009) Microincision vitrectomy surgery and intravitreal bevacizumab as a surgical adjunct to treat diabetic traction retinal detachment. Ophthalmology 116:927–938CrossRefPubMed
13.
go back to reference Ahmadieh H, Shoeibi N, Entezari M, Monshizadeh R (2009) Intravitreal bevacizumab for prevention of early postvitrectomy hemorrhage in diabetic patients: a randomized clinical trial. Ophthalmology 116:1943–1948CrossRefPubMed Ahmadieh H, Shoeibi N, Entezari M, Monshizadeh R (2009) Intravitreal bevacizumab for prevention of early postvitrectomy hemorrhage in diabetic patients: a randomized clinical trial. Ophthalmology 116:1943–1948CrossRefPubMed
14.
go back to reference Lee BJ, Yu HG (2010) Vitreous hemorrhage after the 25-gauge transconjunctival sutureless vitrectomy for proliferative diabetic retinopathy. Retina 30:1671–1677CrossRefPubMed Lee BJ, Yu HG (2010) Vitreous hemorrhage after the 25-gauge transconjunctival sutureless vitrectomy for proliferative diabetic retinopathy. Retina 30:1671–1677CrossRefPubMed
15.
go back to reference Sato T, Morita S, Bando H, Sato S, Ikeda T, Emi K (2013) Early vitreous hemorrhage after vitrectomy with preoperative intravitreal bevacizumab for proliferative diabetic retinopathy. Middle East Afr J Ophthalmol 20:51–55CrossRefPubMedPubMedCentral Sato T, Morita S, Bando H, Sato S, Ikeda T, Emi K (2013) Early vitreous hemorrhage after vitrectomy with preoperative intravitreal bevacizumab for proliferative diabetic retinopathy. Middle East Afr J Ophthalmol 20:51–55CrossRefPubMedPubMedCentral
16.
go back to reference [No authors listed] (1985) Two-year course of visual acuity in severe proliferative diabetic retinopathy with conventional management. Diabetic Retinopathy Vitrectomy Study (DRVS) report #1. Ophthalmology 92:492–502 [No authors listed] (1985) Two-year course of visual acuity in severe proliferative diabetic retinopathy with conventional management. Diabetic Retinopathy Vitrectomy Study (DRVS) report #1. Ophthalmology 92:492–502
17.
go back to reference Oshima Y, Kadonosono K, Yamaji H, Inoue M, Yoshida M, Kimura H, Ohji M, Shiraga F, Hamasaki T, Japan Microincision Vitrectomy Surgery Study Group (2010) Multicenter survey with a systemic overview of acute-onset endophthalmitis after transconjunctival microincision vitrectomy surgery. Am J Ophthalmol 150:716.e1–725.e1CrossRef Oshima Y, Kadonosono K, Yamaji H, Inoue M, Yoshida M, Kimura H, Ohji M, Shiraga F, Hamasaki T, Japan Microincision Vitrectomy Surgery Study Group (2010) Multicenter survey with a systemic overview of acute-onset endophthalmitis after transconjunctival microincision vitrectomy surgery. Am J Ophthalmol 150:716.e1–725.e1CrossRef
18.
go back to reference Schulze-Bonsel K, Feltgen N, Burau H, Hansen L, Bach M (2006) Visual acuities “hand motion” and “counting fingers” can be quantified with the Freiburg visual acuity test. Invest Ophthalmol Vis Sci 47:1236–1240CrossRefPubMed Schulze-Bonsel K, Feltgen N, Burau H, Hansen L, Bach M (2006) Visual acuities “hand motion” and “counting fingers” can be quantified with the Freiburg visual acuity test. Invest Ophthalmol Vis Sci 47:1236–1240CrossRefPubMed
19.
go back to reference Grover S, Fishman GA, Anderson RJ, Tozatti MS, Heckenlively JR, Weleber RG, Edwards AO, Brown J Jr (1999) Visual acuity impairment in patients with retinitis pigmentosa at age 45 year or older. Ophthalmology 106:1780–1785CrossRefPubMed Grover S, Fishman GA, Anderson RJ, Tozatti MS, Heckenlively JR, Weleber RG, Edwards AO, Brown J Jr (1999) Visual acuity impairment in patients with retinitis pigmentosa at age 45 year or older. Ophthalmology 106:1780–1785CrossRefPubMed
20.
go back to reference Rand LI, Prud’homme GJ, Ederer F, Canner PL (1985) Factors influencing the development of visual loss in advanced diabetic retinopathy. Diabetic Retinopathy Study (DRS) Report No. 10. Invest Ophthalmol Vis Sci 26:983–991PubMed Rand LI, Prud’homme GJ, Ederer F, Canner PL (1985) Factors influencing the development of visual loss in advanced diabetic retinopathy. Diabetic Retinopathy Study (DRS) Report No. 10. Invest Ophthalmol Vis Sci 26:983–991PubMed
21.
go back to reference Krieger AE (1991) The pars plana incision: experimental studies, pathologic observations, and clinical experience. Trans Am Ophthalmol Soc 89:549–621PubMedPubMedCentral Krieger AE (1991) The pars plana incision: experimental studies, pathologic observations, and clinical experience. Trans Am Ophthalmol Soc 89:549–621PubMedPubMedCentral
22.
go back to reference Bhende M, Agraharam SG, Gopal L et al (2000) Ultrasound biomicroscopy of sclerotomy sites after pars plana vitrectomy for diabetic vitreous hemorrhage. Ophthalmology 107:1729–1736CrossRefPubMed Bhende M, Agraharam SG, Gopal L et al (2000) Ultrasound biomicroscopy of sclerotomy sites after pars plana vitrectomy for diabetic vitreous hemorrhage. Ophthalmology 107:1729–1736CrossRefPubMed
23.
go back to reference Hershberger VS, Augsburger JJ, Hutchins RK, Raymond LA, Krug S (2004) Fibrovascular ingrowth at sclerotomy sites in vitrectomized diabetic eyes with recurrent vitreous hemorrhage: ultrasound biomicroscopy findings. Ophthalmology 111:1215–1221CrossRefPubMed Hershberger VS, Augsburger JJ, Hutchins RK, Raymond LA, Krug S (2004) Fibrovascular ingrowth at sclerotomy sites in vitrectomized diabetic eyes with recurrent vitreous hemorrhage: ultrasound biomicroscopy findings. Ophthalmology 111:1215–1221CrossRefPubMed
24.
go back to reference Rezende FA, Qian CX, Robert MC (2013) Fibrovascular ingrowth after 25-gauge transconjunctival vitrectomy in proliferative diabetic retinopathy. Ophthalmic Surg Lasers Imaging Retina 44:405–408CrossRefPubMed Rezende FA, Qian CX, Robert MC (2013) Fibrovascular ingrowth after 25-gauge transconjunctival vitrectomy in proliferative diabetic retinopathy. Ophthalmic Surg Lasers Imaging Retina 44:405–408CrossRefPubMed
25.
go back to reference Zehetner C, Kirchmair R, Kralinger M, Kieselbach G (2013) Correlation of vascular endothelial growth factor plasma levels and glycemic control in patients with diabetic retinopathy. Acta Ophthalmol 91:e470–e473CrossRefPubMed Zehetner C, Kirchmair R, Kralinger M, Kieselbach G (2013) Correlation of vascular endothelial growth factor plasma levels and glycemic control in patients with diabetic retinopathy. Acta Ophthalmol 91:e470–e473CrossRefPubMed
26.
go back to reference Jain A, Saxena S, Khanna VK, Shukla RK, Meyer CH (2013) Status of serum VEGF and ICAM-1 and its association with external limiting membrane and inner segment-outer segment junction disruption in type 2 diabetes mellitus. Mol Vis 19:1760–1768PubMedPubMedCentral Jain A, Saxena S, Khanna VK, Shukla RK, Meyer CH (2013) Status of serum VEGF and ICAM-1 and its association with external limiting membrane and inner segment-outer segment junction disruption in type 2 diabetes mellitus. Mol Vis 19:1760–1768PubMedPubMedCentral
27.
go back to reference Shichiri M, Kishikawa H, Ohkubo Y, Wake N (2000) Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients. Diabetes Care 23(Suppl 2):B21–B29PubMed Shichiri M, Kishikawa H, Ohkubo Y, Wake N (2000) Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients. Diabetes Care 23(Suppl 2):B21–B29PubMed
Metadata
Title
Characteristics of cases with postoperative vitreous hemorrhage after 25-gauge vitrectomy for repair of proliferative diabetic retinopathy
Authors
Tatsuhiko Sato
Kotaro Tsuboi
Hiroshi Nakashima
Kazuyuki Emi
Publication date
01-04-2017
Publisher
Springer Berlin Heidelberg
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 4/2017
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-016-3522-8

Other articles of this Issue 4/2017

Graefe's Archive for Clinical and Experimental Ophthalmology 4/2017 Go to the issue