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Child's Nervous System

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01-06-2021 | Original Article

Characteristics and overall survival in pediatric versus adult skull base chordoma: a population-based study

Authors: Jordan C. Xu, Brandon M. Lehrich, Tyler M. Yasaka, Brendan M. Fong, Frank P. K. Hsu, Edward C. Kuan

Published in: Child's Nervous System | Issue 6/2021

Abstract

Purpose

Less than 5% of chordomas occur in pediatric patients. While many studies have explored the treatment and outcomes of skull base chordomas, few have focused on the differences between pediatric and adult populations. The aim of this study is to analyze the epidemiological variables and clinical outcomes between pediatric and adult skull base chordomas using a large-sample, population-based cancer database.

Methods

The National Cancer Database was queried between 2004 and 2015 for skull base chordomas. We stratified patients as pediatric (<18 years) and adults (≥18 years). We compared several clinical covariates between the two groups.

Results

Our cohort consisted of 658 patients, 61 pediatric (9.3%), and 597 adults (90.7%). Pediatric patients were more likely to have larger tumor size (41.4 ± 15.7 mm versus 34.1 ± 15.8 mm, p < 0.01) and universally treated at academic facilities. There was no significant difference in overall survival.

Conclusions

Pediatric skull base chordomas are rare tumors that are managed with aggressive surgical resection, followed by radiation. While there may be difference between tumor presentation, outcomes between pediatric and adult patients are similar.

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Title: Characteristics and overall survival in pediatric versus adult skull base chordoma: a population-based study
Authors: Jordan C. Xu
Brandon M. Lehrich
Tyler M. Yasaka
Brendan M. Fong
Frank P. K. Hsu
Edward C. Kuan
Publication date: 01-06-2021
Publisher: Springer Berlin Heidelberg
Published in: Child's Nervous System / Issue 6/2021
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-021-05046-6

At a glance: The STEP trials

Springer Medicine

Characteristics and overall survival in pediatric versus adult skull base chordoma: a population-based study

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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