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Japanese Journal of Ophthalmology
Published in: Japanese Journal of Ophthalmology 4/2015

01-07-2015 | Clinical Investigation

Characteristic correlations of the structure-function relationship in different glaucomatous disc types

Authors: Kazuko Omodaka, Naoko Takada, Takuhiro Yamaguchi, Hidetoshi Takahashi, Makoto Araie, Toru Nakazawa

Published in: Japanese Journal of Ophthalmology | Issue 4/2015

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Abstract

Purpose

To investigate the influence of the optic disc type on the overall and regional correlation between structure and function in open angle glaucoma (OAG).

Methods

We divided 144 eyes of 144 patients with OAG into four groups according to Nicolela et al.’s classification of optic disc type: focal ischemic (FI), myopic glaucomatous (MY), senile sclerotic (SS), and generalized enlargement (GE). We measured the circumpapillary retinal nerve fiber layer thickness (cpRNFLT) with the 3D OCT-2000 and the mean deviation (MD) with the Humphrey Field Analyzer in each group and determined the influence of the disc type on these parameters with the Spearman rank correlation.

Results

We found that cpRNFLT and MD were significantly correlated in the MY (r = 0.61, P < 0.001), GE (r = 0.62, P < 0.001), and SS groups (r = 0.52, P = 0.002), but not in the FI group (r = 0.25, P = 0.130). The region of the optic disc with the highest correlation coefficient between structure and function differed according to the disc type.

Conclusions

The correlation between cpRNFLT and MD varied according to the optic disc morphology in OAG. This suggests that different disc types have characteristic regional variations in the correlation between structure and function. The disc type should therefore be considered in investigations of the correlation between structure and function in glaucoma.
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Metadata
Title
Characteristic correlations of the structure-function relationship in different glaucomatous disc types
Authors
Kazuko Omodaka
Naoko Takada
Takuhiro Yamaguchi
Hidetoshi Takahashi
Makoto Araie
Toru Nakazawa
Publication date
01-07-2015
Publisher
Springer Japan
Published in
Japanese Journal of Ophthalmology / Issue 4/2015
Print ISSN: 0021-5155
Electronic ISSN: 1613-2246
DOI
https://doi.org/10.1007/s10384-015-0379-z

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