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01-12-2017 | Original Communication

Characterisation of pain in people with hereditary neuropathy with liability to pressure palsy

Authors: Darren Beales, Robyn Fary, Cameron Little, Shruti Nambiar, Hakon Sveinall, Yen Leng Yee, Brigitte Tampin, Tim Mitchell

Published in: Journal of Neurology | Issue 12/2017

Abstract

Hereditary neuropathy with liability to pressure palsy (HNPP) has historically been considered a pain-free condition, though some people with HNPP also complain of pain. This study characterised persistent pain in people with HNPP. Participants provided cross-sectional demographic data, information on the presence of neurological and persistent pain symptoms, and the degree to which these interfered with daily life. The painDETECT and Central Sensitization Inventory questionnaires were used to indicate potential neuropathic, central sensitisation and musculoskeletal (nociceptive) pain mechanisms. Additionally, participants were asked if they thought that pain was related to/part of HNPP. 32/43 (74%) subjects with HNPP had persistent pain and experience this pain in the last week. Of those with pain, 24 (75%) were likely to have neuropathic pain and 27 (84%) were likely to have central sensitisation. All 32 participants felt that their pain could be related to/part of their HNPP. Significant negative impact of the pain was common. Pain characterisation identified neuropathic pain and/or central sensitisation as common, potential underlying processes. Pain may plausibly be directly related to the underlying pathophysiology of HNPP. Further consideration of including pain as a primary symptom of HNPP is warranted.

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Title: Characterisation of pain in people with hereditary neuropathy with liability to pressure palsy
Authors: Darren Beales
Robyn Fary
Cameron Little
Shruti Nambiar
Hakon Sveinall
Yen Leng Yee
Brigitte Tampin
Tim Mitchell
Publication date: 01-12-2017
Publisher: Springer Berlin Heidelberg
Published in: Journal of Neurology / Issue 12/2017
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-017-8648-z

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Characterisation of pain in people with hereditary neuropathy with liability to pressure palsy

Abstract

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