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01-03-2016 | Anesthesia for Trauma (JW Simmons, Section Editor)

Changing Paradigms in Hemostatic Resuscitation: Timing, Extent, Economic Impact, and the Role of Factor Concentrates

Authors: Roman Dudaryk, Nadav Sheffy, John R. Hess

Published in: Current Anesthesiology Reports | Issue 1/2016

Abstract

Damage-controlled hemostatic resuscitation has become a standard of care for critically injured patients. Recently completed PROPRR trial demonstrated hemostatic benefits of 1:1:1 Platelets:FFP:RBC transfusion approach, although overall mortality did not decrease. Improved logistics of resuscitation (decreased crystalloid administration), optimization of blood product delivery with adoption of massive transfusion protocols (short time to first unit of plasma transfused), and better early post-MTP management are the factors that contributed to lower than expected mortality in this study. Liquid plasma and pre-thawed Type A fresh frozen plasma (FFP) are safe alternatives to universal donor Type AB FFP and have been adopted by few trauma centers in North America due to shortage of AB FFP supply.

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Title: Changing Paradigms in Hemostatic Resuscitation: Timing, Extent, Economic Impact, and the Role of Factor Concentrates
Authors: Roman Dudaryk
Nadav Sheffy
John R. Hess
Publication date: 01-03-2016
Publisher: Springer US
Published in: Current Anesthesiology Reports / Issue 1/2016
Electronic ISSN: 2167-6275
DOI: https://doi.org/10.1007/s40140-016-0143-z

At a glance: The STEP trials

Springer Medicine

Changing Paradigms in Hemostatic Resuscitation: Timing, Extent, Economic Impact, and the Role of Factor Concentrates

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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