Top

Published in:

01-12-2007 | Original Article

Changes of collagen type III and decorin in paraurethral connective tissue from women with stress urinary incontinence and prolapse

Authors: Yanfeng Song, Xinru Hong, Yan Yu, Yibin Lin

Published in: International Urogynecology Journal | Issue 12/2007

Abstract

Thirteen premenopausal women with stress urinary incontinence (SUI), 6 with SUI and prolapse, 9 with prolapse, and 19 without prolapse were enrolled to observe the content change of collagen type III and the expression of decorin mRNA in paraurethral connective tissues. Collagen type III from transvaginal biopsies was assayed by immunohistochemical staining and decorin mRNA was detected by real-time PCR. Premenopausal women with SUI had a significantly decreased level of collagen type III. Decorin mRNA expression was significantly increased in both premenopausal SUI+prolapse group and premenopausal prolapse group reflected by the decrease of ΔCt value compared to their corresponding controls. The results suggest that a high level of decorin mRNA might be associated with the reduced content of collagen type III, resulting in a less flexible form of extracellular matrix in the connective tissue in SUI and prolapse patients.

Petros PE, Ulmsten UI (1990) An integral theory of female urinary incontinence. Experimental and clinical considerations. Acta Obstet Gynecol Scand Suppl 153:7–31PubMed

Liu X, Zhao Y, Pawlyk B, Damaser M, Li T (2006) Failure of elastic fiber homeostasis leads to pelvic floor disorders. Am J Pathol 168:519–528PubMedCrossRef

Abrams P, Blaivas JG, Stanton S, Andersen JT (1988) The standardisation of terminology of lower urinary tract function. Neurourol Urodyn 7:403–426CrossRef

Liapis A, Bakas P, Pafiti A, Frangos-Plemenos M, Arnoyannaki N, Creatsas G (2001) Changes of collagen type III in female patients with genuine stress incontinence and pelvic floor prolapse. Eur J Obstet Gynecol Reprod Biol 97:76–79PubMedCrossRef

Hannestad YS, Rortveit G, Sandvik H, Hunskaar S (2000) A community-based epidemiological survey of female urinary incontinence: the Norwegian EPINCONT study. Epidemiology of Incontinence in the County of Nord Trondelag. J Clin Epidemiol 53:1150–1157PubMedCrossRef

Salter SA, Batra RS, Rohrer TE, Kohli N, Kimball AB (2006) Striae and pelvic relaxation: two disorders of connective tissue with a strong association. J Invest Dermatol 126(8):1745–1748PubMedCrossRef

Rechberger T, Postawski K, Jakowicki JA, Gunja-Smith Z, Woessner JF Jr (1998) Role of fascial collagen in stress urinary incontinence. Am J Obstet Gynecol 179:1511–1514PubMedCrossRef

Keane DP, Sims TJ, Abrams P, Bailey AJ (1997) Analysis of collagen status in premenopausal nulliparous women with genuine stress incontinence. Br J Obstet Gynaecol 104:994–998PubMed

Bergman A, Elia G, Cheung D, Perelman N, Nimni ME (1994) Biochemical composition of collagen in continent and stress urinary incontinent women. Gynecol Obstet Invest 37:48–51PubMedCrossRef

10.

Nimni ME (1983) Collagen: structure, function, and metabolism in normal and fibrotic tissues. Semin Arthritis Rheum 13:1–86PubMedCrossRef

11.

Weber KT (1989) Cardiac interstitium in health and disease: the fibrillar collagen network. J Am Coll Cardiol 13:1637–1652PubMedCrossRef

12.

Vesentini S, Redaelli A, Montevecchi FM (2005) Estimation of the binding force of the collagen molecule-decorin core protein complex in collagen fibril. J Biomech 38:433–443PubMedCrossRef

13.

Danielson KG, Baribault H, Holmes DF, Graham H, Kadler KE, Iozzo RV (1997) Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility. J Cell Biol 136:729–743PubMedCrossRef

14.

Mietz H, Chevez-Barrios P, Lieberman MW, Wendt M, Gross R, Basinger SF (1997) Decorin and suramin inhibit ocular fibroblast collagen production. Graefes Arch Clin Exp Ophthalmol 235:399–403PubMedCrossRef

15.

Neame PJ, Kay CJ, McQuillan DJ, Beales MP, Hassell JR (2000) Independent modulation of collagen fibrillogenesis by decorin and lumican. Cell Mol Life Sci 57:859–863PubMedCrossRef

16.

Watanabe T, Hosaka Y, Yamamoto E, Ueda H, Sugawara K, Takahashi H, Takehana K (2005) Control of the collagen fibril diameter in the equine superficial digital flexor tendon in horses by decorin. J Vet Med Sci 67:855–860PubMedCrossRef

17.

Chen B, Wen Y, Zhang Z, Wang H, Warrington JA, Polan ML (2003) Menstrual phase-dependent gene expression differences in periurethral vaginal tissue from women with stress incontinence. Am J Obstet Gynecol 189:89–97PubMedCrossRef

Title: Changes of collagen type III and decorin in paraurethral connective tissue from women with stress urinary incontinence and prolapse
Authors: Yanfeng Song
Xinru Hong
Yan Yu
Yibin Lin
Publication date: 01-12-2007
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 12/2007
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-007-0356-2

At a glance: The STEP trials

Springer Medicine

Changes of collagen type III and decorin in paraurethral connective tissue from women with stress urinary incontinence and prolapse

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 12/2007

Double trouble: two complicated slings in one woman

A histotopographic study of the perineal body in elderly women: the surgical applicability of novel histological findings

Pregnancy after TVT-O: case report and literature review

Sedation and local anaesthesia for vaginal pelvic floor repair of genital prolapse using mesh

Long-term results of sigmoid vaginoplasty in a consecutive series of 62 patients

Treatment outcome of tension-free vaginal tape in stress urinary incontinence: comparison of intrinsic sphincter deficiency and nonintrinsic sphincter deficiency patients