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World Journal of Surgery

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Open Access 01-04-2011

Changes in the Localization of Perforated Peptic Ulcer and its Relation to Gender and Age of the Patients throughout the Last 45 Years

Authors: Andrzej Wysocki, Piotr Budzyński, Jan Kulawik, Włodzimierz Drożdż

Published in: World Journal of Surgery | Issue 4/2011

Abstract

Background

Throughout recent decades there has been noticeable change in the incidence of peptic ulcer disease and its complications. The aim of the present study was to determine the character of changes over the last 45 years in the localization of perforation, in patient age, and in patient gender.

Methods

A group of 881 patients admitted to the Second Department of General Surgery in Krakow, Poland, from 1962 to 2006 were included in the study and constituted the material for the analysis. The study was divided into three time periods (1962–1976, 1977–1991, and 1992–2006) to allow statistical analysis of trends.

Results

The general incidence of perforations of peptic ulcer did not show changes; however, the percentage of women with perforated duodenal ulcer markedly increased. Patients with perforated stomach ulcer—regardless of gender—and females suffering from perforated duodenal ulcer were, on the average, about 10 years older than males with perforated duodenal ulcers. The mean age of male and female patients with perforated duodenal ulcer over the last 45 years showed an insignificant upward trend.

Conclusions

(1) The percentage of women with perforated duodenal ulcer continuously and statistically significantly rose. (2) Men with perforated duodenal ulcer were significantly younger than other patients. (3) The mean ages of male and female patients with perforated duodenal ulcer over the last 45 years showed an insignificant upward trend.

Bardhan KD, Cust G, Hinchliffe RF et al (1989) Changing pattern of admissions and operations for duodenal ulcer. Br J Surg 76:230–236PubMedCrossRef

Johnsen R, Straume B, Forde OH et al (1992) Changing incidence of peptic ulcer—facts or artefacts? A cohort study from Tromso. J Epidemiol Community Health 46:433–436PubMedCrossRef

Rosenstock S, Jorgensen T, Bonnevie O et al (2003) Risk factors for peptic ulcer disease: a population based prospective cohort study comprising 2,416 Danish adults. Gut 52:186–193PubMedCrossRef

Schoon IM, Mellstrom D, Oden A et al (1989) Incidence of peptic ulcer disease in Gothenburg, 1985. BMJ 299(6708):1131–1134PubMedCrossRef

Wang YR, Richter JE, Dempsey DT (2010) Trends and outcomes of hospitalizations for peptic ulcer disease in the United States, 1993 to 2006. Ann Surg 251:51–58PubMedCrossRef

Wu CY, Wu CH, Wu MS et al (2009) A nationwide population-based cohort study shows reduced hospitalization for peptic ulcer disease associated with H. pylori eradication and proton pump inhibitor use. Clin Gastroenterol Hepatol 7:427–431PubMedCrossRef

Jennings D (1940) Perforated peptic ulcer: changes in age-incidence and sex-distribution in the last 150 years. Lancet 1:444–447CrossRef

Mikulicz J (1885) O laparotomii w przypadkach przedziurawienia żołądka i jelita. Przegl. Lek XXIV(2):1–3

Lau WY, Leow CK (1997) History of perforated duodenal and gastric ulcers. World J Surg 21:890–896PubMedCrossRef

10.

Crisp E (1843) Cases of perforation of the stomach with deductions there from relative to the character and treatment of that lesion. Lancet 2:639CrossRef

11.

Lanas A, Garcia-Rodriguez LA, Polo-Tomas M et al (2009) Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practice. Am J Gastroenterol 104:1633–1641PubMedCrossRef

12.

Lassen A, Hallas J, de Schaffalitzky Muckadell OB (2006) Complicated and uncomplicated peptic ulcers in a Danish county 1993–2002: a population-based cohort study. Am J Gastroenterol 101:945–953PubMedCrossRef

13.

Lohsiriwat V, Prapasrivorakul S, Lohsiriwat D (2009) Perforated peptic ulcer: clinical presentation, surgical outcomes, and the accuracy of the Boey scoring system in predicting postoperative morbidity and mortality. World J Surg 33:80–85PubMedCrossRef

14.

Bertleff MJ, Halm JA, Bemelman WA et al (2009) Randomized clinical trial of laparoscopic versus open repair of the perforated peptic ulcer: the LAMA trial. World J Surg 33:1368–1373PubMedCrossRef

15.

Bardhan KD, Royston C (2008) Time, change and peptic ulcer disease in Rotherham, UK. Dig Liver Dis 40:540–546PubMedCrossRef

16.

Russo P, Brutti C (2007) Proton pump inhibitors and hospital discharge rates for gastrointestinal events in Italy: a national ecological study. Clin Ther 29:751–758PubMedCrossRef

17.

Kang JY, Elders A, Majeed A et al (2006) Recent trends in hospital admissions and mortality rates for peptic ulcer in Scotland 1982–2002. Aliment Pharmacol Ther 24:65–79PubMedCrossRef

18.

Hermansson M, Ekedahl A, Ranstam J et al (2009) Decreasing incidence of peptic ulcer complications after the introduction of the proton pump inhibitors, a study of the Swedish population from 1974–2002. BMC Gastroenterol 9:25PubMedCrossRef

19.

Janik J, Chwirot P (2000) Perforated peptic ulcer—time trends and patterns over 20 years. Med Sci Monit 6:369–372PubMed

20.

Brown RC, Langman MJ, Lambert PM (1976) Hospital admissions for peptic ulcer during 1958–72. BMJ 1(6000):35–37PubMedCrossRef

21.

Koo J, Ngan YK, Lam SK (1983) Trends in hospital admission, perforation and mortality of peptic ulcer in Hong Kong from 1970 to 1980. Gastroenterology 84:1558–1562PubMed

22.

Kopelman D (2009) Perforated peptic ulcer: “developing” world versus “developed” world. World J Surg 33:86–87PubMedCrossRef

23.

Lazarus S (1964) Perforated peptic ulcer in Israel. Gut 5:590–596PubMedCrossRef

24.

Mackay C, Mackay HP (1976) Proceedings: perforated peptic ulcer in the west of Scotland 1964–73. Br J Surg 63:157–158PubMed

25.

Sanchez-Bueno F, Marin P, Rios A et al (2001) Has the incidence of perforated peptic ulcer decreased over the last decade? Dig Surg 18:444–447 discussion 447–448PubMedCrossRef

26.

Sanders R (1967) Incidence of perforated duodenal and gastric ulcer in Oxford. Gut 8:58–63PubMedCrossRef

27.

Watkins RM, Dennison AR, Collin J (1984) What has happened to perforated peptic ulcer? Br J Surg 71:774–776PubMedCrossRef

28.

Armstrong CP, Blower AL (1987) Non-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration. Gut 28:527–532PubMedCrossRef

29.

Collier DS, Pain JA (1985) Non-steroidal anti-inflammatory drugs and peptic ulcer perforation. Gut 26:359–363PubMedCrossRef

30.

Gustavsson S, Kelly KA, Melton LJ 3rd et al (1988) Trends in peptic ulcer surgery. A population-based study in Rochester, Minnesota, 1956–1985. Gastroenterology 94:688–694PubMed

31.

Kato I, Nomura AM, Stemmermann GN et al (1992) A prospective study of gastric and duodenal ulcer and its relation to smoking, alcohol, and diet. Am J Epidemiol 135:521–530PubMed

32.

Jibril JA, Redpath A, Macintyre IM (1994) Changing pattern of admission and operation for duodenal ulcer in Scotland. Br J Surg 81:87–89PubMedCrossRef

33.

MacKay C (1966) Perforated peptic ulcer in the west of Scotland: a survey of 5,343 cases during 1954–63. Br Med J 1(5489):701–705PubMedCrossRef

34.

McKay AJ, McArdle CS (1982) Cimetidine and perforated peptic ulcer. Br J Surg 69:319–320PubMedCrossRef

35.

Valerio D, Hendry W, Kyle G (1982) Gastroduodenal perforation in North East Scotland, 1972–1981; a rise in incidence. Gut 23:38–39

36.

Svanes C (2000) Trends in perforated peptic ulcer: incidence, etiology, treatment, and prognosis. World J Surg 24:277–283PubMedCrossRef

37.

Thors H, Svanes C, Thjodleifsson B (2002) Trends in peptic ulcer morbidity and mortality in Iceland. J Clin Epidemiol 55:681–686PubMedCrossRef

38.

Svanes C, Salvesen H, Stangeland L et al (1993) Perforated peptic ulcer over 56 years. Time trends in patients and disease characteristics. Gut 34:1666–1671PubMedCrossRef

39.

Canoy DS, Hart AR, Todd CJ (2002) Epidemiology of duodenal ulcer perforation: a study on hospital admissions in Norfolk, United Kingdom. Dig Liver Dis 34:322–327PubMedCrossRef

40.

Negre J (1985) Perforated ulcer in elderly people. Lancet 2(8464):1118–1119PubMedCrossRef

41.

Svanes C, Soreide JA, Skarstein A et al (1997) Smoking and ulcer perforation. Gut 41:177–180PubMedCrossRef

42.

Garcia Rodriguez LA, Jick H (1994) Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory drugs. Lancet 343(8900):769–772PubMedCrossRef

43.

Coggon D, Lambert P, Langman MJ (1981) 20 years of hospital admissions for peptic ulcer in England and Wales. Lancet 1(8233):1302–1304PubMedCrossRef

44.

Gisbert JP, Pajares JM (2003) Helicobacter pylori infection and perforated peptic ulcer prevalence of the infection and role of antimicrobial treatment. Helicobacter 8:159–167PubMedCrossRef

45.

Ng EK, Chung SC, Sung JJ et al (1996) High prevalence of Helicobacter pylori infection in duodenal ulcer perforations not caused by non-steroidal anti-inflammatory drugs. Br J Surg 83:1779–1781PubMedCrossRef

46.

Christensen A, Bousfield R, Christiansen J (1988) Incidence of perforated and bleeding peptic ulcers before and after the introduction of H2-receptor antagonists. Ann Surg 207:4–6PubMedCrossRef

47.

Paimela H, Tuompo PK, Perakyl T et al (1991) Peptic ulcer surgery during the H2-receptor antagonist era: a population-based epidemiological study of ulcer surgery in Helsinki from 1972 to 1987. Br J Surg 78:28–31PubMedCrossRef

Title: Changes in the Localization of Perforated Peptic Ulcer and its Relation to Gender and Age of the Patients throughout the Last 45 Years
Authors: Andrzej Wysocki
Piotr Budzyński
Jan Kulawik
Włodzimierz Drożdż
Publication date: 01-04-2011
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 4/2011
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-010-0917-2

At a glance: The STEP trials

Springer Medicine

Changes in the Localization of Perforated Peptic Ulcer and its Relation to Gender and Age of the Patients throughout the Last 45 Years

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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