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European Archives of Oto-Rhino-Laryngology
Published in: European Archives of Oto-Rhino-Laryngology 5/2006

01-05-2006 | Otology

Changes in distortion of two-tone cochlear microphonic and otoacoustic emission signals during an acute endolymphatic hydrops in the guinea pig

Authors: W. L. Valk, H. P. Wit, F. W. J. Albers

Published in: European Archives of Oto-Rhino-Laryngology | Issue 5/2006

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Abstract

An acute endolymphatic hydrops was induced by the injection of 1.1 μl of artificial endolymph into the scala media of guinea pig cochleas. This volume corresponds with an acute endolymphatic hydrops of 23%. During and after the injection, cochlear function was assessed by measuring the 2f1-f2 and f2-f1 distortion products in cochlear microphonics (CMDP) and the 2f1-f2 distortion product otoacoustic emission (DPOAE). A reversible pressure increase of 23 Pa and a relatively stable endocochlear potential (EP) were accompanied by a mean decrease in 2f1-f2 DPOAE of only 3.4 dB. Similarly, the 2f1-f2 CMDP amplitude change was minimal during and after the injection. The only substantial change was measured in the f2-f1 CMDP amplitude. The measured range of distortion amplitudes during an acute endolymphatic hydrops can be related to small changes in the cochlear transducer operating point.
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Metadata
Title
Changes in distortion of two-tone cochlear microphonic and otoacoustic emission signals during an acute endolymphatic hydrops in the guinea pig
Authors
W. L. Valk
H. P. Wit
F. W. J. Albers
Publication date
01-05-2006
Publisher
Springer-Verlag
Published in
European Archives of Oto-Rhino-Laryngology / Issue 5/2006
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-005-1035-x

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