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Open Access 01-12-2012 | Review

Challenges and opportunities in patient-specific, motion-managed and PET/CT-guided radiation therapy of lung cancer: review and perspective

Authors: Stephen R Bowen, Matthew J Nyflot, Michael Gensheimer, Kristi R G Hendrickson, Paul E Kinahan, George A Sandison, Shilpen A Patel

Published in: Clinical and Translational Medicine | Issue 1/2012

Abstract

The increasing interest in combined positron emission tomography (PET) and computed tomography (CT) to guide lung cancer radiation therapy planning has been well documented. Motion management strategies during treatment simulation PET/CT imaging and treatment delivery have been proposed to improve the precision and accuracy of radiotherapy. In light of these research advances, why has translation of motion-managed PET/CT to clinical radiotherapy been slow and infrequent? Solutions to this problem are as complex as they are numerous, driven by large inter-patient variability in tumor motion trajectories across a highly heterogeneous population. Such variation dictates a comprehensive and patient-specific incorporation of motion management strategies into PET/CT-guided radiotherapy rather than a one-size-fits-all tactic. This review summarizes challenges and opportunities for clinical translation of advances in PET/CT-guided radiotherapy, as well as in respiratory motion-managed radiotherapy of lung cancer. These two concepts are then integrated into proposed patient-specific workflows that span classification schemes, PET/CT image formation, treatment planning, and adaptive image-guided radiotherapy delivery techniques.

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Title: Challenges and opportunities in patient-specific, motion-managed and PET/CT-guided radiation therapy of lung cancer: review and perspective
Authors: Stephen R Bowen
Matthew J Nyflot
Michael Gensheimer
Kristi R G Hendrickson
Paul E Kinahan
George A Sandison
Shilpen A Patel
Publication date: 01-12-2012
Publisher: Springer Berlin Heidelberg
Published in: Clinical and Translational Medicine / Issue 1/2012
Electronic ISSN: 2001-1326
DOI: https://doi.org/10.1186/2001-1326-1-18

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Challenges and opportunities in patient-specific, motion-managed and PET/CT-guided radiation therapy of lung cancer: review and perspective

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Keynote webinar | Spotlight on medication adherence

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Abstract

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Clinical and translational medicine: Integrative and practical science.

Peptidomic profiles of post myocardial infarction rats affinity depleted plasma using matrix-assisted laser desorption/ionization time of flight (MALDI-ToF) mass spectrometry

The impact of saliva collection and processing methods on CRP, IgE, and Myoglobin immunoassays

Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer

Precision medicine: an approach to R&D for delivering superior medicines to patients