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European Journal of Medical Research

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Open Access 01-12-2023 | Cervical Cancer | Review

Research progress on the GRP78 gene in the diagnosis, treatment and immunity of cervical cancer

Authors: Yingying Bai, Wenhua Wang, Yuemei Cheng, Yongxiu Yang

Published in: European Journal of Medical Research | Issue 1/2023

Abstract

Background

GRP78 is a molecular chaperone protein in the endoplasmic reticulum that is involved in protein assembly and quality control, and it participates in ER stress regulation of endoplasmic reticulum stress pathways. Studies have confirmed that GRP78 gene is highly expressed in a variety of tumors and is involved in different biological functions.

Purpose

The present review highlights the involvement of the GRP78 gene in regulating the development of cervical cancer by promoting the proliferation and invasion of cervical cancer cells as well as by inhibiting apoptosis and promoting the Warburg effect. High expression of GRP78 is positively correlated with chemotherapy resistance in cervical cancer. GRP78 plays an anticancer role in cervical cancer by regulating autophagy and apoptosis. Mediated immune CD8 + T cells regulate tumor cell immunity and play a role in the application of the HPV vaccine.

Conclusions

GRP78 plays a multifunctional role in cervical cancer and has important therapeutic and diagnostic value.

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Title: Research progress on the GRP78 gene in the diagnosis, treatment and immunity of cervical cancer
Authors: Yingying Bai
Wenhua Wang
Yuemei Cheng
Yongxiu Yang
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Cervical Cancer
Cervical Cancer
Published in: European Journal of Medical Research / Issue 1/2023
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/s40001-023-01241-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Research progress on the GRP78 gene in the diagnosis, treatment and immunity of cervical cancer

Abstract

Background

Purpose

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Purpose

Conclusions

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