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Cancer Cell International
Published in: Cancer Cell International 1/2020

01-12-2020 | Cervical Cancer | Primary research

MAP7 promotes migration and invasion and progression of human cervical cancer through modulating the autophagy

Authors: Li Zhang, Xudong Liu, Lina Song, Hui Zhai, Chaohua Chang

Published in: Cancer Cell International | Issue 1/2020

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Abstract

Background

Microtubule-associated proteins 7(MAP7) was reported to be engaged into the function of neuronal function. The function of MAP7 in human cervical cancer (CC) was unknown. We aimed to uncover the function and mechanism of MAP7 on CC.

Methods

We applied qRT-PCR, western blot and immunochemistry to detect the expression difference between normal tissue and CC. In vitro, we establish MAP7 stable knocking down and overexpression cell lines and investigated the function and underlying mechanism of MAP7 in CC.

Results

Both mRNA and protein of MAP7 were upregulated in CC compared with the normal tissue. MAP7 was correlated with the clinical stage and tumor size and lymph node metastasis. MAP7 promotes the invasion and migration of CC cell lines. We next detected EMT pathway and autophagy associated pathway. MAP7 promotes the EMT through modulating the autophagy.

Conclusion

Taken above, our results showed that MAP7 promotes the migration and invasion and EMT through modulating the autophagy.
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Metadata
Title
MAP7 promotes migration and invasion and progression of human cervical cancer through modulating the autophagy
Authors
Li Zhang
Xudong Liu
Lina Song
Hui Zhai
Chaohua Chang
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2020
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-020-1095-4

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