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BMC Cancer

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Open Access 01-12-2021 | Cervical Cancer | Research

Lymphatic leakage after pelvic lymphadenectomy for cervical cancer: a retrospective case-control study

Authors: Li Chen, Liang Lin, Ling Li, Zuolian Xie, Haixin He, Cuibo Lin, Jian Chen, An Lin

Published in: BMC Cancer | Issue 1/2021

Abstract

Background

The study aims to evaluate the clinical features and management of postoperative lymphatic leakage (PLL) in patients with cervical cancer who received pelvic lymphadenectomy.

Methods

This retrospective study screened consecutive patients with cervical cancer (stage Ia2-IIb).

Results

Among 3427 cases screened, 63 patients (1.8%) were diagnosed with PLL, which manifested as persistent abdominal drainage (42/63, 66.7%), chylous ascites (12/63, 19.0%) or vaginal drainage (9/63, 14.3%). Median time from surgery to onset of PLL was 6 days (range, 4–21 days). All cases resolved in a median 10 days (range, 3–56 days) after conservative treatment; although one case experienced recurrence of vaginal drainage after 26 days, this also resolved after conservative therapy. Multivariate analysis showed that two cycles of neoadjuvant chemotherapy (odds ratio [OR], 3.283; 95% confidence interval [95%CI], 1.289–8.360; P = 0.013), a decrease in hemoglobin level of ≥20 and < 30 g/L (OR, 6.175; 95%CI, 1.033–10.919; P = 0.046) or ≥ 30 g/L (OR, 8.467; 95%CI, 1.248–17.426; P = 0.029), and postoperative albumin level ≥ 30 and < 35 g/L (OR, 2.552; 95%CI, 1.112–5.857; P = 0.027) or < 30 g/L (OR, 5.517; 95%CI, 2.047–18.148; P = 0.012) were associated with PLL.

Conclusion

Neoadjuvant chemotherapy, postoperative anemia and postoperative hypoproteinemia are risk factors for PLL.

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Title: Lymphatic leakage after pelvic lymphadenectomy for cervical cancer: a retrospective case-control study
Authors: Li Chen
Liang Lin
Ling Li
Zuolian Xie
Haixin He
Cuibo Lin
Jian Chen
An Lin
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Cervical Cancer
Cervical Cancer
Ascites
Lymphadenectomy
Published in: BMC Cancer / Issue 1/2021
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-021-08984-1

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Abstract

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