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01-08-2021 | Cervical Cancer | Brief Report

Gastric-type cervical adenocarcinoma with squamous differentiation: buried in adenosquamous carcinomas?

Authors: Hiroshi Yoshida, Tomoaki Naka, Mayumi Kobayashi-Kato, Nao Kikkawa, Yasuhito Tanase, Masaya Uno, Mitsuya Ishikawa, Tomoyasu Kato

Published in: Virchows Archiv | Issue 2/2021

Abstract

Gastric-type adenocarcinoma (GAS) of the cervix is a human papilloma virus (HPV)–independent, aggressive, and chemo-resistant adenocarcinoma. However, although the histopathological features of GAS have been extensively investigated, squamous differentiation has not been mentioned. This study aimed to elucidate the frequency of GAS with squamous differentiation and describe their clinicopathological characteristics. We retrospectively evaluated 78 patients with GAS (n = 13) and adenosquamous carcinoma (n = 65) diagnosed between 2000 and 2020. Two patients with GAS with squamous differentiation were identified. Both tumors showed advanced stage (pT2bN1) and had predominant GAS and merged squamous cell carcinoma components without p16-block positivity and HPV DNA. Gastric-type adenocarcinoma in situ was confirmed in both cases. Some cases of GAS could show squamous differentiation mimicking the usual, HPV-associated, adenosquamous carcinoma. GAS with squamous differentiation is recognized as an HPV-independent cancer.

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Title: Gastric-type cervical adenocarcinoma with squamous differentiation: buried in adenosquamous carcinomas?
Authors: Hiroshi Yoshida
Tomoaki Naka
Mayumi Kobayashi-Kato
Nao Kikkawa
Yasuhito Tanase
Masaya Uno
Mitsuya Ishikawa
Tomoyasu Kato
Publication date: 01-08-2021
Publisher: Springer Berlin Heidelberg
Keywords: Cervical Cancer
Cervical Cancer
Published in: Virchows Archiv / Issue 2/2021
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-020-02997-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Gastric-type cervical adenocarcinoma with squamous differentiation: buried in adenosquamous carcinomas?

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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