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05-08-2022 | Cervical Cancer | Case Study

Combined-modality treatment for locally advanced cervical cancer in a woman with Bloom-like syndrome: A case report and review of the literature

Authors: Syrine Ben Dhia, Hugo Berthou, Mathilde Warcoin, Manuel Rodrigues, Aurélien Noret, Arnaud Beddok, Nina Weber, Dominique Stoppa Lyonnet, Nathaniel Scher

Published in: Strahlentherapie und Onkologie | Issue 1/2023

Abstract

We report the case of a 46-year-old woman with Bloom-like syndrome affected with locally advanced cervical cancer. She was treated with induction chemotherapy and radical radiation therapy concurrent with chemotherapy (carboplatin and paclitaxel). She was able to complete treatment, but grade III toxicities were observed. The limited relevant literature is presented. We conclude that the management of patients with DNA repair deficiency is challenging for the team in charge because of the potentially high sensitivity to treatment and the lack of clear recommendations in the literature. The main objective remains to deliver the optimal treatment while reducing toxicities.

Cunniff C, Djavid AR, Carrubba S, Cohen B, Ellis NA, Levy CF et al (2018) Health supervision for people with Bloom syndrome. Am J Med Genet 176(9):1872–1881CrossRef

Fedhila-Ben Ayed F, Douira-Khomsi W, Rhayem S, Jelassi M, Zribi H, Chaabouni M et al (2016) Burkitt lymphoma in a child with Bloom syndrome. Arch Pediatr 23(4):382–384CrossRef

Ma B, Corry J, Rischin D, Leong T, Peters LJ (2001) Combined modality treatment for locally advanced squamous-cell carcinoma of the oropharynx in a woman with Bloom’s syndrome: A case report and review of the literature. Ann Oncol 12(7):1015–1017CrossRef

Arora H, Chacon AH, Choudhary S, McLeod MP, Meshkov L, Nouri K et al (2014) Bloom syndrome. Int J Dermatol 53(7):798–802CrossRef

Cunniff C, Bassetti JA, Ellis NA (2017) Bloom’s syndrome: clinical spectrum, molecular pathogenesis, and cancer predisposition. Mol Syndromol 8(1):4–23CrossRef

Moreira MB, Quaio CRD, Zandoná-Teixeira AC, Novo-Filho GM, Zanardo EA, Kulikowski LD et al (2013) Discrepant outcomes in two Brazilian patients with Bloom syndrome and Wilms’ tumor: two case reports. J Med Case Reports 7(1):284CrossRef

Brosh RM, Bohr VA (2007) Human premature aging, DNA repair and RecQ helicases. Nucleic Acids Res 35(22):7527–7544CrossRef

Thomas ERA, Shanley S, Walker L, Eeles R (2008) Surveillance and treatment of malignancy in bloom syndrome. Clin Oncol 20(5):375–379CrossRef

Walsh MF, Chang VY, Kohlmann WK, Scott HS, Cunniff C, Bourdeaut F et al (2017) Recommendations for childhood cancer screening and surveillance in DNA repair disorders. Clin Cancer Res 23(11):e23–e31CrossRef

10.

Kataoka M, Kawamura M, Hamamoto K, Takemiya M, Miki Y (1989) Radiation-induced oesophageal stricture in a case of Bloom’s syndrome. Clin Oncol 1(1):47–48CrossRef

11.

Mizumoto M, Hashii H, Senarita M, Sakai S, Wada T, Okumura T et al (2013) Proton beam therapy for malignancy in Bloom syndrome. Strahlenther Onkol 189(4):335–338CrossRef

12.

Priscila CBM, Anjos CS, Victor RDL, Rapatoni L, Fernanda PM (2017) Toxicity of chemotherapy in a patient with bloom syndrome’s diagnosis. J Pharm Pharmacol. https://doi.org/10.17265/2328-2150/2017.07.006CrossRef

Title: Combined-modality treatment for locally advanced cervical cancer in a woman with Bloom-like syndrome: A case report and review of the literature
Authors: Syrine Ben Dhia
Hugo Berthou
Mathilde Warcoin
Manuel Rodrigues
Aurélien Noret
Arnaud Beddok
Nina Weber
Dominique Stoppa Lyonnet
Nathaniel Scher
Publication date: 05-08-2022
Publisher: Springer Berlin Heidelberg
Keywords: Cervical Cancer
Cervical Cancer
Cytostatic Therapy
Published in: Strahlentherapie und Onkologie / Issue 1/2023
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-022-01981-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Combined-modality treatment for locally advanced cervical cancer in a woman with Bloom-like syndrome: A case report and review of the literature

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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