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Published in: Journal of Neural Transmission 2/2016

01-02-2016 | Neurology and Preclinical Neurological Studies - Review Article

Cerebrovascular and mitochondrial abnormalities in Alzheimer’s disease: a brief overview

Authors: Cristina Carvalho, Sónia C. Correia, George Perry, Rudy J. Castellani, Paula I. Moreira

Published in: Journal of Neural Transmission | Issue 2/2016

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Abstract

Multiple lines of evidence suggest that vascular alterations contribute to Alzheimer’s disease (AD) pathogenesis. It is also well established that mitochondrial abnormalities occur early in course of AD. Here, we give an overview of the vascular and mitochondrial abnormalities occurring in AD, including mitochondrial alterations in vascular endothelial cells within the brain, which is emerging as a common feature that bridges cerebral vasculature and mitochondrial metabolism.
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Metadata
Title
Cerebrovascular and mitochondrial abnormalities in Alzheimer’s disease: a brief overview
Authors
Cristina Carvalho
Sónia C. Correia
George Perry
Rudy J. Castellani
Paula I. Moreira
Publication date
01-02-2016
Publisher
Springer Vienna
Published in
Journal of Neural Transmission / Issue 2/2016
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-015-1367-7

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