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Child's Nervous System
Published in: Child's Nervous System 5/2017

01-05-2017 | Original Paper

Cerebrospinal fluid neuron specific enolase, interleukin-1β and erythropoietin concentrations in children after seizures

Authors: Ling-min Shi, Rui-jie Chen, Hui Zhang, Chun-ming Jiang, Jian Gong

Published in: Child's Nervous System | Issue 5/2017

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Abstract

Purpose

In the present study, the levels of neuron-specific enolase (NSE), interleukin-1β (IL-1β), and erythropoietin (EPO) in cerebrospinal fluid (CSF) in children with idiopathic epilepsy were measured to illuminate the relationships between these markers with idiopathic epilepsy.

Methods

Eighty-five children from 6 months to 12.5 years of age with single, previously undiagnosed, and untreated idiopathic epilepsy were participated in this study. The concentrations of CSF NSE, 1L-1β, and EPO were measured by specific ELISA methods.

Results

The mean concentrations of CSF NSE, IL-1β, and EPO in the epileptic groups showed a significant increase (P < 0.01) compared with those in the control groups. Besides, the mutual correlations of NSE, 1L-1β, and EPO were also analyzed. Results showed that there were positive correlations between the levels of IL-1β, NSE, and EPO.

Conclusions

The changes of NSE, 1L-1β, and EPO level in CSF may be beneficial for the pathophysiology study of epileptic seizures and the identification and diagnosis of a seizure clinically.
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Metadata
Title
Cerebrospinal fluid neuron specific enolase, interleukin-1β and erythropoietin concentrations in children after seizures
Authors
Ling-min Shi
Rui-jie Chen
Hui Zhang
Chun-ming Jiang
Jian Gong
Publication date
01-05-2017
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 5/2017
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-017-3359-4

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