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01-08-2013 | Neurology and Preclinical Neurological Studies - Original Article

Cerebroprotective potential of resveratrol through anti-oxidant and anti-inflammatory mechanisms in rats

Authors: Prabhakar Orsu, B. V. S. N. Murthy, Annapurna Akula

Published in: Journal of Neural Transmission | Issue 8/2013

Abstract

Oxidative stress and inflammation are two important pathological mechanisms involved in cerebral ischemia and reperfusion injury. In pathological conditions such as cerebral infarction, the free radical production is greater than that of elimination by endogenous anti-oxidant system, by this undesirable effect brain is highly injured. Resveratrol is reported to have anti-oxidant and anti-inflammatory, athero-protective activities. Therefore, the aim of the present study is to evaluate the therapeutic potential of resveratrol against cerebral infarction induced by ischemia and reperfusion injury in Wistar rats. Bi-common carotid occlusion followed by 4 h reperfusion model was used to induce cerebral infarction. Percent infarction, oxidative stress markers (malondialdehyde, catalase, superoxide dismutase) and inflammatory markers (myeloperoxidase, TNF-α, IL-6, ICAM-1 and IL-10) were measured. TNF-α, IL-6, IL-10, and intracellular adhesive molecule-I (ICAM-1) levels were quantified by enzyme-linked immunosorbent assay (ELISA). Resveratrol produced significant dose-dependent reduction in percent cerebral infarct volume. At resveratrol 20 mg/kg dose, there was a significant reduction in oxidative stress and inflammatory markers like malondialdehyde, TNF-α, IL-6, myeloperoxidase and ICAM-I and in contrast there was a significant increase in anti-oxidants and anti-inflammatory markers like superoxide dismutase, catalase and IL-10 levels. Resveratrol showed significant cerebroprotective action mediated by anti-oxidant and anti-inflammatory mechanisms.

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Title: Cerebroprotective potential of resveratrol through anti-oxidant and anti-inflammatory mechanisms in rats
Authors: Prabhakar Orsu
B. V. S. N. Murthy
Annapurna Akula
Publication date: 01-08-2013
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 8/2013
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-013-0982-4

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Cerebroprotective potential of resveratrol through anti-oxidant and anti-inflammatory mechanisms in rats

Abstract

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