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BMC Gastroenterology

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Open Access 01-12-2020 | Cerebral Sinus Venous Thrombosis | Case report

Concurrent cerebral arterial and venous sinus thrombosis revealing celiac disease- a case report and literature review

Authors: Dalia Alhosain, Lamia Kouba

Published in: BMC Gastroenterology | Issue 1/2020

Abstract

Background

Celiac disease is an autoimmune condition characterized by an inappropriate immune reaction against gluten. It classically presents as chronic diarrhea, bloating, and nausea in addition to malabsorption symptoms such as weight loss and micronutrient deficiency. We report the first case of coinciding cerebral infarction and venous sinus thrombosis unveiling the diagnosis of celiac disease.

Case presentation

A 40-year old female patient with a four-day history of severe diarrhea presented with right hemiplegia and altered mental status. Imaging revealed left middle cerebral artery occlusion and left transverse and sigmoid venous sinus thrombosis, along with left jugular vein thrombosis. Her laboratory evaluation was notable for profound iron deficiency anemia, thrombocytosis, and hyperhomocysteinemia. Her positive anti-tissue transglutaminase IgA antibodies and ensuing duodenal biopsy confirmed the diagnosis of celiac disease.

Conclusions

Celiac disease has a wide range of intestinal and extraintestinal manifestations and can present with thrombotic events in young patients with iron deficiency and hyperhomocysteinemia.

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Title: Concurrent cerebral arterial and venous sinus thrombosis revealing celiac disease- a case report and literature review
Authors: Dalia Alhosain
Lamia Kouba
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Cerebral Sinus Venous Thrombosis
Stroke
Iron Deficiency
Iron Deficiency Anemia
Celiac Disease
Thrombosis
Celiac Disease
Published in: BMC Gastroenterology / Issue 1/2020
Electronic ISSN: 1471-230X
DOI: https://doi.org/10.1186/s12876-020-01483-w

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