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Open Access 01-02-2016 | Neuro

Cerebral perfusion in the predementia stages of Alzheimer’s disease

Authors: Maja A. A. Binnewijzend, Marije R. Benedictus, Joost P. A. Kuijer, Wiesje M. van der Flier, Charlotte E. Teunissen, Niels D. Prins, Mike P. Wattjes, Bart N.M. van Berckel, Philip Scheltens, Frederik Barkhof

Published in: European Radiology | Issue 2/2016

Abstract

Objectives

To investigate arterial spin-labelling (ASL) cerebral blood flow (CBF) changes in predementia stages of Alzheimer’s disease (AD).

Methods

Data were obtained from 177 patients with subjective complaints, mild cognitive impairment and AD from the Amsterdam Dementia Cohort. AD stages were based on diagnosis and cerebrospinal fluid biomarkers amyloid-β (Aβ) and total-tau (tau). General-linear-models were used to assess relationships between AD stages and total and regional CBF, correcting for age and sex.

Results

Decreasing CBF was related to more advanced AD stages in all supratentorial regions (p for trend < 0.05). Post-hoc testing revealed that CBF was lower in AD compared to controls and stage-1 predementia patients (i.e. abnormal Aβ and normal tau) in temporal and parietal regions, and compared to stage-2 predementia patients (i.e. abnormal Aβ and tau) in temporal regions. CBF values of stage-2 predementia patients were numerically in between those of stage-1 predementia patients and AD.

Conclusion

The continuing decrease of CBF along the continuum of AD indicates the potential of ASL-CBF as a measure for disease progression.

Key Points

• Decreasing CBF relates to more advanced AD stages in all supratentorial regions.

• The reduction of CBF does not reach a bottom level.

• ASL-CBF has potential as a measure for disease progression in AD.

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Title: Cerebral perfusion in the predementia stages of Alzheimer’s disease
Authors: Maja A. A. Binnewijzend
Marije R. Benedictus
Joost P. A. Kuijer
Wiesje M. van der Flier
Charlotte E. Teunissen
Niels D. Prins
Mike P. Wattjes
Bart N.M. van Berckel
Philip Scheltens
Frederik Barkhof
Publication date: 01-02-2016
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 2/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-3834-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Cerebral perfusion in the predementia stages of Alzheimer’s disease

Abstract

Objectives

Methods

Results

Conclusion

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

Key Points

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