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01-04-2014 | Diagnostic Neuroradiology

Cerebral amyloid angiopathy-related inflammation: imaging findings and clinical outcome

Authors: Matia Martucci, Silvana Sarria, Manuel Toledo, Pilar Coscojuela, Carla Vert, Sahyly Siurana, Cristina Auger, Alex Rovira

Published in: Neuroradiology | Issue 4/2014

Abstract

Introduction

We aim to investigate the clinical onset, computed tomography (CT) and magnetic resonance (MR) imaging findings, and follow-up of patients with cerebral amyloid angiopathy (CAA)-related inflammation, an uncommon but clinically striking presentation of CAA.

Methods

We retrospectively reviewed the clinical manifestations, CT/MR imaging findings, and outcome of ten consecutive patients with CAA-related inflammation. In each patient, a brain CT study was performed at hospital admission, and brain MR imaging was carried out 2 to 4 days later. Clinical and radiologic follow-up findings were evaluated in all patients.

Results

The most common clinical onset was rapidly progressive cognitive decline, followed by focal neurological signs. Brain CT/MR showed unenhanced expansive subcortical lesions, corresponding to areas of vasogenic edema, associated with chronic lobar, cortical, or cortical–subcortical micro/macrohemorrhages. Clinical symptoms recovered in a few weeks under treatment in eight patients and spontaneously in the remaining two. MRI follow-up at 2 to 12 months after treatment showed resolution of the lesions. Three patients experienced symptomatic disease recurrence, with new lesions on CT/MR.

Conclusion

In the absence of histological data, early recognition of the clinical symptoms and typical radiologic features of CAA-related inflammation is essential to enable timely establishment of proper treatment.

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Title: Cerebral amyloid angiopathy-related inflammation: imaging findings and clinical outcome
Authors: Matia Martucci
Silvana Sarria
Manuel Toledo
Pilar Coscojuela
Carla Vert
Sahyly Siurana
Cristina Auger
Alex Rovira
Publication date: 01-04-2014
Publisher: Springer Berlin Heidelberg
Published in: Neuroradiology / Issue 4/2014
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-014-1330-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Cerebral amyloid angiopathy-related inflammation: imaging findings and clinical outcome

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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