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01-08-2021 | Central Pontine Myelinolysis | History of Neurology

Central pontine myelinolysis secondary to rapid correction of hyponatremia historical perspective with Doctor Robert Laureno

Author: Guillaume Lamotte

Published in: Neurological Sciences | Issue 8/2021

Abstract

Objectives

Central pontine myelinolysis (CPM) is a neurological disorder characterized by damage to the myelin and oligodendrocytes in the pons. This review focuses on the history of CPM and the discovery of its association with the treatment of hyponatremia.

Methods

The author reviewed original publications regarding CPM, hyponatremia, and the treatment of hyponatremia. The author interviewed Dr. Robert Laureno who was a pioneer in CPM research with his animal work in dogs.

Results

Animal models demonstrated the role of the rapid correction of hyponatremia as causative of pontine and extrapontine myelinolytic lesions. Nevertheless, the importance of the speed of correction was widely denied. There were years of debates and only slow changes in expert guidelines.

Conclusion

CPM occurs as a consequence of a rapid rise in serum sodium in individuals with chronic hyponatremia. It is recommended to increase plasma sodium concentration by no more than 8 to 10 mmol/L per 24 h in chronic hyponatremia.

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Title: Central pontine myelinolysis secondary to rapid correction of hyponatremia historical perspective with Doctor Robert Laureno
Author: Guillaume Lamotte
Publication date: 01-08-2021
Publisher: Springer International Publishing
Keywords: Central Pontine Myelinolysis
Hyponatremia
Published in: Neurological Sciences / Issue 8/2021
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-021-05301-3

At a glance: The STEP trials

Springer Medicine

Central pontine myelinolysis secondary to rapid correction of hyponatremia historical perspective with Doctor Robert Laureno

Abstract

Objectives

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

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