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Critical Care
Published in: Critical Care 3/2012

01-06-2012 | Letter

CD4+ T-lymphocyte alterations in trauma patients

Authors: Aurélie Gouel-Chéron, Fabienne Venet, Bernard Allaouchiche, Guillaume Monneret

Published in: Critical Care | Issue 3/2012

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Excerpt

We read with great interest the article by Heffernan and colleagues reporting an association between persistent lymphopaenia and increasing mortality in trauma patients [1]. We would like to provide some additional data obtained in a similar cohort of patients. …
Literature
1.
Heffernan DS, Monaghan SF, Thakkar RK, Machan JT, Cioffi WG, Ayala A: Failure to normalize lymphopenia following trauma is associated with increased mortality, independent of the leukocytosis pattern. Crit Care 2012, 16: R12. 10.1186/cc11157PubMedCentralCrossRefPubMed
2.
Cheron A, Floccard B, Allaouchiche B, Guignant C, Poitevin F, Malcus C, Crozon J, Faure A, Guillaume C, Marcotte G, Vulliez A, Monneuse O, Monneret G: Lack of recovery in monocyte human leukocyte antigen-DR expression is independently associated with the development of sepsis after major trauma. Crit Care 2010, 14: R208. 10.1186/cc9331PubMedCentralCrossRefPubMed
3.
Venet F, Chung CS, Kherouf H, Geeraert A, Malcus C, Poitevin F, Bohé J, Lepape A, Ayala A, Monneret G: Increased circulating regulatory T cells (CD4 + CD25 + CD127 - ) contribute to lymphocyte anergy in septic shock patients. Intensive Care Med 2009, 35: 678-686. 10.1007/s00134-008-1337-8PubMedCentralCrossRefPubMed
4.
Docke WD, Hoflich C, Davis KA, Rottgers K, Meisel C, Kiefer P, Weber SU, Hedwig-Geissing M, Kreuzfelder E, Tschentscher P, Nebe T, Engel A, Monneret G, Spittler A, Schmolke K, Reinke P, Volk HD, Kunz D: Monitoring temporary immunodepression by flow cytometric measurement of monocytic HLADR expression: a multicenter standardized study. Clin Chem 2005, 51: 2341-2347. 10.1373/clinchem.2005.052639CrossRefPubMed
Metadata
Title
CD4+ T-lymphocyte alterations in trauma patients
Authors
Aurélie Gouel-Chéron
Fabienne Venet
Bernard Allaouchiche
Guillaume Monneret
Publication date
01-06-2012
Publisher
BioMed Central
Published in
Critical Care / Issue 3/2012
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc11376

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