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01-09-2019 | Original Article

CD39 downregulation in chronic intervillositis of unknown etiology

Authors: Yuichiro Sato, Kazunari Maekawa, Murasaki Aman, Atushi Yamashita, Yuki Kodama, Yohei Maki, Hiroshi Sameshima, Yujiro Asada

Published in: Virchows Archiv | Issue 3/2019

Abstract

Chronic intervillositis of unknown etiology (CIUE) is a rare placental lesion associated with infiltration of mononuclear inflammatory cells into the intervillous space, poor perinatal outcomes (intrauterine fetal demise or fetal growth restriction), and high rates of recurrence. CD39 is the ectonucleotidase that protects tissues from inflammatory stress and cell injury, which is localized on the surface of villi in normal placentas; however, its expression and role in CIUE are unknown. The aims of this retrospective study were to determine the expression of CD39 in CIUE and its significance in pregnancy outcomes. We compared the number of CD68- and CD3-positive cells, CD39 expression, and complement 4d (C4d) and fibrin deposition in placental tissues from patients with CIUE (n = 22) and gestational age-matched controls (n = 20), and between CIUE pregnancies with poor and good outcomes. The numbers of CD68- or CD3-positive cells were significantly higher (P < 0.0001), whereas CD39 expression on the surface of villi and endothelial cells of the stem villi was significantly lower in the CIUE group than that in controls (45% vs. 95%, P < 0.0001 and 77% vs. 96%, P < 0.001, respectively). C4d and fibrin deposition were also significantly increased in CIUE compared with those of controls. Furthermore, CD39 downregulation and the number of CD68 cells were strongly associated with poor pregnancy outcomes (P < 0.01 and P < 0.05, respectively), but other histological parameters (CD3, C4d, and fibrin) did not show this association. Our study suggests that CD39 downregulation is a useful marker of CIUE and is associated with poor pregnancy outcomes in patients with CIUE.

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Title: CD39 downregulation in chronic intervillositis of unknown etiology
Authors: Yuichiro Sato
Kazunari Maekawa
Murasaki Aman
Atushi Yamashita
Yuki Kodama
Yohei Maki
Hiroshi Sameshima
Yujiro Asada
Publication date: 01-09-2019
Publisher: Springer Berlin Heidelberg
Published in: Virchows Archiv / Issue 3/2019
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-019-02598-6

At a glance: The STEP trials

Springer Medicine

CD39 downregulation in chronic intervillositis of unknown etiology

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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