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Open Access 01-01-2019 | Brief Report

CD200 expression is a feature of solid pseudopapillary neoplasms of the pancreas

Authors: Rita T. Lawlor, Valentina Daprà, Ilaria Girolami, Antonio Pea, Camilla Pilati, Alessia Nottegar, Paola Piccoli, Claudia Parolini, Nicola Sperandio, Paola Capelli, Aldo Scarpa, Claudio Luchini

Published in: Virchows Archiv | Issue 1/2019

Abstract

CD200 has been recently indicated as a robust marker of well-differentiated neuroendocrine neoplasms. Here, we evaluate its role in differential diagnosis of solid pancreatic neoplasms. We immunostained for CD200 22 solid pseudopapillary neoplasms (SPNs), 8 acinar carcinomas (ACs), 2 pancreatoblastomas (PBs), 138 neuroendocrine tumors (PanNETs), and 48 ductal adenocarcinomas. All SPNs showed strong cytoplasmic and membranous staining for CD200, while only one case of AC had focal positivity. The two PBs showed focal CD200 positivity, mainly located in squamoid nests. The vast majority of PanNETs (96%) showed strong cytoplasmic and membranous staining for CD200, whereas all PDACs were negative. As both PanNETs and SPNs express CD200, it has no role in the differential diagnosis between these two entities.

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Title: CD200 expression is a feature of solid pseudopapillary neoplasms of the pancreas
Authors: Rita T. Lawlor
Valentina Daprà
Ilaria Girolami
Antonio Pea
Camilla Pilati
Alessia Nottegar
Paola Piccoli
Claudia Parolini
Nicola Sperandio
Paola Capelli
Aldo Scarpa
Claudio Luchini
Publication date: 01-01-2019
Publisher: Springer Berlin Heidelberg
Published in: Virchows Archiv / Issue 1/2019
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-018-2437-7

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CD200 expression is a feature of solid pseudopapillary neoplasms of the pancreas

Abstract

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