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Pediatric Rheumatology
Published in: Pediatric Rheumatology 1/2014

Open Access 01-09-2014 | Poster presentation

CD161+ regulatory t cells in immune regulation

Authors: Chantal Duurland, Tony Brooks, Mike Hubank, Ryan O'Shaughnessy, Lucy Wedderburn

Published in: Pediatric Rheumatology | Special Issue 1/2014

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Excerpt

Regulatory T cells (Treg) are crucial for maintaining immune homeostasis and mediating immune tolerance. Several studies have shown that Treg can produce cytokines. CD161, a C-type lectin receptor, identifies Treg that produce cytokines. Interestingly, CD161+ Treg are enriched in the inflamed joint of Juvenile Idiopathic Arthritis (JIA) patients and their numbers relate to clinical disease severity suggesting that CD161+ Treg may play an important role in disease pathogenesis. If Treg are to be used as a cell therapy it may be important to define ways to prevent cytokine production from these cells in vivo. …
Metadata
Title
CD161+ regulatory t cells in immune regulation
Authors
Chantal Duurland
Tony Brooks
Mike Hubank
Ryan O'Shaughnessy
Lucy Wedderburn
Publication date
01-09-2014
Publisher
BioMed Central
Published in
Pediatric Rheumatology / Issue Special Issue 1/2014
Electronic ISSN: 1546-0096
DOI
https://doi.org/10.1186/1546-0096-12-S1-P39

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