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01-08-2013 | Poster presentation

CD11b and TLR4 in human neutrophil priming by endotoxins from Escherichia coli

Authors: Isabella Prokhorenko, Dimitry Kabanov, Svetlana Zubova, Sergay Grachev

Published in: Critical Care | Special Issue 4/2013

Excerpt

The interaction of endotoxins (lipopolysaccharides (LPS)) from Gram-negative bacteria with peripheral blood mononuclear cells leads to the assembly of a receptor cluster composed from mCD14, CD11b/CD18, TLR4, CD16A and CD36 [1, 2]. It is well known that the main signal transducing receptor complex is TLR4/MD-2 while mCD14 is involved in the recognition of S or R endotoxin's glycoforms [3, 4]. A growing body of evidence indicates that the CD11b/CD18 receptor plays the significant role in the endotoxin signaling machinery because it can influence TLR4-mediated cell activation [5]. So, using mAbs, we carried out experiments to elucidate the influence of CD11b inhibition on neutrophil priming by endotoxins for N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced respiratory burst. …

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Title: CD11b and TLR4 in human neutrophil priming by endotoxins from Escherichia coli
Authors: Isabella Prokhorenko
Dimitry Kabanov
Svetlana Zubova
Sergay Grachev
Publication date: 01-08-2013
Publisher: BioMed Central
Published in: Critical Care / Issue Special Issue 4/2013
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc12974

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CD11b and TLR4 in human neutrophil priming by endotoxins from Escherichia coli

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