Skip to main content
Top
Published in: Population Health Metrics 1/2010

Open Access 01-12-2010 | Research

Cause-of-death ascertainment for deaths that occur outside hospitals in Thailand: application of verbal autopsy methods

Authors: Warangkana Polprasert, Chalapati Rao, Timothy Adair, Junya Pattaraarchachai, Yawarat Porapakkham, Alan D Lopez

Published in: Population Health Metrics | Issue 1/2010

Login to get access

Abstract

Background

Ascertainment of cause for deaths that occur in the absence of medical attention is a significant problem in many countries, including Thailand, where more than 50% of such deaths are registered with ill-defined causes. Routine implementation of standardized, rigorous verbal autopsy methods is a potential solution. This paper reports findings from field research conducted to develop, test, and validate the use of verbal autopsy (VA) methods in Thailand.

Methods

International verbal autopsy methods were first adapted to the Thai context and then implemented to ascertain causes of death for a nationally representative sample of 11,984 deaths that occurred in Thailand in 2005. Causes of death were derived from completed VA questionnaires by physicians trained in ICD-based cause-of-death certification. VA diagnoses were validated in the sample of hospital deaths for which reference diagnoses were available from medical record review. Validated study findings were used to adjust VA-based causes of death derived for deaths in the study sample that had occurred outside hospitals. Results were used to estimate cause-specific mortality patterns for deaths outside hospitals in Thailand in 2005.

Results

VA-based causes of death were derived for 6,328 out of 7,340 deaths in the study sample that had occurred outside hospitals, constituting the verification arm of the study. The use of VA resulted in large-scale reassignment of deaths from ill-defined categories to specific causes of death. The validation study identified that VA tends to overdiagnose important causes such as diabetes, liver cancer, and tuberculosis, while undercounting deaths from HIV/AIDS, liver diseases, genitourinary (essential renal), and digestive system disorders.

Conclusions

The use of standard VA methods adapted to Thailand enabled a plausible assessment of cause-specific mortality patterns and a substantial reduction of ill-defined diagnoses. Validation studies enhance the utility of findings from the application of verbal autopsy. Regular implementation of VA in Thailand could accelerate development of the quality and utility of vital registration data for deaths outside hospitals.
Appendix
Available only for authorised users
Literature
1.
go back to reference Bureau of Planning and Strategy: Mortality Database. Bangkok: Ministry of Public Health, Thailand; 2008. Bureau of Planning and Strategy: Mortality Database. Bangkok: Ministry of Public Health, Thailand; 2008.
2.
go back to reference Tangcharoensathien V, Faramnuayphol P, Teokul W, Bundhamcharoen K, Wibulpholprasert S: A critical assessment of mortality statistics in Thailand: potential for improvements. Bull World Health Organ 2006, 84: 233-8. 10.2471/BLT.05.026310CrossRefPubMedPubMedCentral Tangcharoensathien V, Faramnuayphol P, Teokul W, Bundhamcharoen K, Wibulpholprasert S: A critical assessment of mortality statistics in Thailand: potential for improvements. Bull World Health Organ 2006, 84: 233-8. 10.2471/BLT.05.026310CrossRefPubMedPubMedCentral
3.
go back to reference Ministry of Public Health Thailand: Mortality system in Thailand. In Regional Consultation on Mortality Statistics. New Delhi: WHO Regional Office for South-East Asia; 2007. Ministry of Public Health Thailand: Mortality system in Thailand. In Regional Consultation on Mortality Statistics. New Delhi: WHO Regional Office for South-East Asia; 2007.
4.
go back to reference Choprapawon C, Porapakkham Y, Sablon O, Panjajaru R, Jhantharatat B: Thailand's national death registration reform: verifying the causes of death between July 1997 and December 1999. Asia Pac J Public Health 2005, 17: 110-6.CrossRefPubMed Choprapawon C, Porapakkham Y, Sablon O, Panjajaru R, Jhantharatat B: Thailand's national death registration reform: verifying the causes of death between July 1997 and December 1999. Asia Pac J Public Health 2005, 17: 110-6.CrossRefPubMed
5.
go back to reference Fauveau V: Assessing probable causes of death without death registration or certificates: a new science. Bull World Health Organ 2006, 84: 246-7.PubMedPubMedCentral Fauveau V: Assessing probable causes of death without death registration or certificates: a new science. Bull World Health Organ 2006, 84: 246-7.PubMedPubMedCentral
7.
go back to reference Fauveau V, Koenig MA, Chakraborty J, Chowdhury AI: Causes of maternal mortality in rural Bangladesh, 1976-85. Bull World Health Organ 1988, 66: 643-51.PubMedPubMedCentral Fauveau V, Koenig MA, Chakraborty J, Chowdhury AI: Causes of maternal mortality in rural Bangladesh, 1976-85. Bull World Health Organ 1988, 66: 643-51.PubMedPubMedCentral
8.
go back to reference Snow RW, Armstrong JR, Forster D, Winstanley MT, Marsh VM, Newton CR, Wariuru C, Mwangi I, Winstanley PA, Marsh K: Childhood deaths in Africa: uses and limitations of verbal autopsies. Lancet 1992, 340: 351-5. 10.1016/0140-6736(92)91414-4CrossRefPubMed Snow RW, Armstrong JR, Forster D, Winstanley MT, Marsh VM, Newton CR, Wariuru C, Mwangi I, Winstanley PA, Marsh K: Childhood deaths in Africa: uses and limitations of verbal autopsies. Lancet 1992, 340: 351-5. 10.1016/0140-6736(92)91414-4CrossRefPubMed
9.
go back to reference Kamali A, Wagner HU, Nakiyingi J, Sabiiti I, Kengeya-Kayondo JF, Mulder DW: Verbal autopsy as a tool for diagnosing HIV-related adult deaths in rural Uganda. Int J Epidemiol 1996, 25: 679-84. 10.1093/ije/25.3.679CrossRefPubMed Kamali A, Wagner HU, Nakiyingi J, Sabiiti I, Kengeya-Kayondo JF, Mulder DW: Verbal autopsy as a tool for diagnosing HIV-related adult deaths in rural Uganda. Int J Epidemiol 1996, 25: 679-84. 10.1093/ije/25.3.679CrossRefPubMed
10.
go back to reference Kahn K, Tollman SM, Garenne M, Gear JS: Validation and application of verbal autopsies in a rural area of South Africa. Trop Med Int Health 2000, 5: 824-31. 10.1046/j.1365-3156.2000.00638.xCrossRefPubMed Kahn K, Tollman SM, Garenne M, Gear JS: Validation and application of verbal autopsies in a rural area of South Africa. Trop Med Int Health 2000, 5: 824-31. 10.1046/j.1365-3156.2000.00638.xCrossRefPubMed
11.
go back to reference Setel PW, Sankoh O, Rao C, Velkoff VA, Mathers CD, Yang G, Hemed Y, Jha P, Lopez AD: Sample registration of vital events with verbal autopsy: A renewed commitment to measuring and monitoring vital statistics. Bull World Health Organ 2005, 83: 611-7.PubMedPubMedCentral Setel PW, Sankoh O, Rao C, Velkoff VA, Mathers CD, Yang G, Hemed Y, Jha P, Lopez AD: Sample registration of vital events with verbal autopsy: A renewed commitment to measuring and monitoring vital statistics. Bull World Health Organ 2005, 83: 611-7.PubMedPubMedCentral
12.
go back to reference Gajalakshmi V, Peto R, Kanaka S, Balasubramanian S: Verbal autopsy of 48 000 adult deaths attributable to medical causes in Chennai (formerly Madras), India. BMC Public Health 2002, 2: 7. 10.1186/1471-2458-2-7CrossRefPubMedPubMedCentral Gajalakshmi V, Peto R, Kanaka S, Balasubramanian S: Verbal autopsy of 48 000 adult deaths attributable to medical causes in Chennai (formerly Madras), India. BMC Public Health 2002, 2: 7. 10.1186/1471-2458-2-7CrossRefPubMedPubMedCentral
13.
go back to reference Etard JF, Hesran JY, Diallo A, Diallo JP, Ndiaye JL, Delaunay V: Childhood mortality and probable causes of death using verbal autopsy in Niakhar, Senegal, 1989-2000. Int J Epidemiol 2004, 33: 1286-92. 10.1093/ije/dyh259CrossRefPubMed Etard JF, Hesran JY, Diallo A, Diallo JP, Ndiaye JL, Delaunay V: Childhood mortality and probable causes of death using verbal autopsy in Niakhar, Senegal, 1989-2000. Int J Epidemiol 2004, 33: 1286-92. 10.1093/ije/dyh259CrossRefPubMed
14.
go back to reference Quigley MA: Commentary: Verbal autopsies--from small-scale studies to mortality surveillance systems. Int J Epidemiol 2005, 34: 1087-8. 10.1093/ije/dyi135CrossRefPubMed Quigley MA: Commentary: Verbal autopsies--from small-scale studies to mortality surveillance systems. Int J Epidemiol 2005, 34: 1087-8. 10.1093/ije/dyi135CrossRefPubMed
15.
go back to reference Jha P, Gajalakshmi V, Gupta PC, Kumar R, Mony P, Dhingra N, Peto R, RGI-CGHR Prospective Study Collaborators: Prospective study of one million deaths in India: rationale, design, and validation results. PLoS Med 2006, 3: e18. 10.1371/journal.pmed.0030018CrossRefPubMed Jha P, Gajalakshmi V, Gupta PC, Kumar R, Mony P, Dhingra N, Peto R, RGI-CGHR Prospective Study Collaborators: Prospective study of one million deaths in India: rationale, design, and validation results. PLoS Med 2006, 3: e18. 10.1371/journal.pmed.0030018CrossRefPubMed
16.
go back to reference Wang L, Yang G, Jiemin M, Rao C, Wan X, Dubrovsky G, Lopez AD: Evaluation of the quality of cause of death statistics in rural China using verbal autopsies. J Epidemiol Community Health 2007, 61: 519-26. 10.1136/jech.2005.043927CrossRefPubMedPubMedCentral Wang L, Yang G, Jiemin M, Rao C, Wan X, Dubrovsky G, Lopez AD: Evaluation of the quality of cause of death statistics in rural China using verbal autopsies. J Epidemiol Community Health 2007, 61: 519-26. 10.1136/jech.2005.043927CrossRefPubMedPubMedCentral
17.
go back to reference Quigley MA, Armstrong JR, Snow RW: Algorithms for verbal autopsies: a validation study in Kenyan children. Bull World Health Organ 1996, 74: 147-54.PubMedPubMedCentral Quigley MA, Armstrong JR, Snow RW: Algorithms for verbal autopsies: a validation study in Kenyan children. Bull World Health Organ 1996, 74: 147-54.PubMedPubMedCentral
18.
go back to reference Rodriguez L, Reyes H, Tome P, Ridaura C, Flores S, Guiscafre H: Validation of the verbal autopsy method to ascertain acute respiratory infection as cause of death. Indian J Pediatr 1998, 65: 579-84. 10.1007/BF02730899CrossRefPubMed Rodriguez L, Reyes H, Tome P, Ridaura C, Flores S, Guiscafre H: Validation of the verbal autopsy method to ascertain acute respiratory infection as cause of death. Indian J Pediatr 1998, 65: 579-84. 10.1007/BF02730899CrossRefPubMed
19.
go back to reference Benara SK, Singh P: Validity of causes of infant death by verbal autopsy. Indian J Pediatr 1999, 66: 647-50. 10.1007/BF02726242CrossRefPubMed Benara SK, Singh P: Validity of causes of infant death by verbal autopsy. Indian J Pediatr 1999, 66: 647-50. 10.1007/BF02726242CrossRefPubMed
20.
go back to reference Coldham C, Ross D, Quigley M, Segura Z, Chandramohan D: Prospective validation of a standardized questionnaire for estimating childhood mortality and morbidity due to pneumonia and diarrhoea. Trop Med Int Health 2000, 5: 134-44. 10.1046/j.1365-3156.2000.00505.xCrossRefPubMed Coldham C, Ross D, Quigley M, Segura Z, Chandramohan D: Prospective validation of a standardized questionnaire for estimating childhood mortality and morbidity due to pneumonia and diarrhoea. Trop Med Int Health 2000, 5: 134-44. 10.1046/j.1365-3156.2000.00505.xCrossRefPubMed
21.
go back to reference Marsh DR, Sadruddin S, Fikree FF, Krishnan C, Darmstadt GL: Validation of verbal autopsy to determine the cause of 137 neonatal deaths in Karachi, Pakistan. Paediatr Perinat Epidemiol 2003, 17: 132-42. 10.1046/j.1365-3016.2003.00475.xCrossRefPubMed Marsh DR, Sadruddin S, Fikree FF, Krishnan C, Darmstadt GL: Validation of verbal autopsy to determine the cause of 137 neonatal deaths in Karachi, Pakistan. Paediatr Perinat Epidemiol 2003, 17: 132-42. 10.1046/j.1365-3016.2003.00475.xCrossRefPubMed
22.
go back to reference Chandramohan D, Maude GH, Rodrigues LC, Hayes RJ: Verbal autopsies for adult deaths: issues in their development and validation. Int J Epidemiol 1994, 23: 213-22. 10.1093/ije/23.2.213CrossRefPubMed Chandramohan D, Maude GH, Rodrigues LC, Hayes RJ: Verbal autopsies for adult deaths: issues in their development and validation. Int J Epidemiol 1994, 23: 213-22. 10.1093/ije/23.2.213CrossRefPubMed
23.
go back to reference Chandramohan D, Maude GH, Rodrigues LC, Hayes RJ: Verbal autopsies for adult deaths: their development and validation in a multicentre study. Trop Med Int Health 1998, 3: 436-46.CrossRefPubMed Chandramohan D, Maude GH, Rodrigues LC, Hayes RJ: Verbal autopsies for adult deaths: their development and validation in a multicentre study. Trop Med Int Health 1998, 3: 436-46.CrossRefPubMed
24.
go back to reference Yang G, Rao C, Ma J, Wang L, Wan X, Dubrovsky G, Lopez AD: Validation of verbal autopsy procedures for adult deaths in China. Int J Epidemiol 2006, 35: 741-8. 10.1093/ije/dyi181CrossRefPubMed Yang G, Rao C, Ma J, Wang L, Wan X, Dubrovsky G, Lopez AD: Validation of verbal autopsy procedures for adult deaths in China. Int J Epidemiol 2006, 35: 741-8. 10.1093/ije/dyi181CrossRefPubMed
25.
go back to reference Setel PW, Whiting DR, Hemed Y, Chandramohan D, Wolfson LJ, Alberti KG, Lopez AD: Validity of verbal autopsy procedures for determining cause of death in Tanzania. Trop Med Int Health 2006, 11: 681-96. 10.1111/j.1365-3156.2006.01603.xCrossRefPubMed Setel PW, Whiting DR, Hemed Y, Chandramohan D, Wolfson LJ, Alberti KG, Lopez AD: Validity of verbal autopsy procedures for determining cause of death in Tanzania. Trop Med Int Health 2006, 11: 681-96. 10.1111/j.1365-3156.2006.01603.xCrossRefPubMed
26.
go back to reference Byass P, Huong DL, Minh HV: A probabilistic approach to interpreting verbal autopsies: methodology and preliminary validation in Vietnam. Scand J Public Health Suppl 2003, 62: 32-7. 10.1080/14034950310015086CrossRefPubMed Byass P, Huong DL, Minh HV: A probabilistic approach to interpreting verbal autopsies: methodology and preliminary validation in Vietnam. Scand J Public Health Suppl 2003, 62: 32-7. 10.1080/14034950310015086CrossRefPubMed
27.
go back to reference Murray CJ, Lopez AD, Feehan DM, Peter ST, Yang G: Validation of the symptom pattern method for analyzing verbal autopsy data. PLoS Med 2007, 4: e327. 10.1371/journal.pmed.0040327CrossRefPubMedPubMedCentral Murray CJ, Lopez AD, Feehan DM, Peter ST, Yang G: Validation of the symptom pattern method for analyzing verbal autopsy data. PLoS Med 2007, 4: e327. 10.1371/journal.pmed.0040327CrossRefPubMedPubMedCentral
28.
go back to reference Rao C, Porapakkham Y, Pattaraarchachai J, Polprasert W, Swampunyalert , Lopez AD: Verifying causes of death in Thailand: rationale and methods for empirical investigation. Popul Health Metr 2010, 8: 11. 10.1186/1478-7954-8-11CrossRefPubMedPubMedCentral Rao C, Porapakkham Y, Pattaraarchachai J, Polprasert W, Swampunyalert , Lopez AD: Verifying causes of death in Thailand: rationale and methods for empirical investigation. Popul Health Metr 2010, 8: 11. 10.1186/1478-7954-8-11CrossRefPubMedPubMedCentral
29.
go back to reference World Health Organization: Verbal autopsy standards: ascertaining and attributing cause of death. Geneva: World Health Organization; 2007. World Health Organization: Verbal autopsy standards: ascertaining and attributing cause of death. Geneva: World Health Organization; 2007.
30.
go back to reference Ministry of Public Health: Burden of Disease and Injury in Thailand: Priority setting for Policy. Bangkok: Ministry of Public Health, Thailand; 2002. Ministry of Public Health: Burden of Disease and Injury in Thailand: Priority setting for Policy. Bangkok: Ministry of Public Health, Thailand; 2002.
31.
go back to reference Prasartkul P, Porapakkham Y, Wapattanawong P, Rittirong J: Development of a verbal autopsy tool for investigating cause of death. Journal of Population and Social Studies 2007, 15: 1-22. Prasartkul P, Porapakkham Y, Wapattanawong P, Rittirong J: Development of a verbal autopsy tool for investigating cause of death. Journal of Population and Social Studies 2007, 15: 1-22.
32.
go back to reference Setel PW, Rao C, Hemed Y, Whiting DR, Yang G, Chandramohan D, Alberti KG, Lopez AD: Core verbal autopsy procedures with comparative validation results from two countries. PLoS Med 2006, 3: e268. 10.1371/journal.pmed.0030268CrossRefPubMedPubMedCentral Setel PW, Rao C, Hemed Y, Whiting DR, Yang G, Chandramohan D, Alberti KG, Lopez AD: Core verbal autopsy procedures with comparative validation results from two countries. PLoS Med 2006, 3: e268. 10.1371/journal.pmed.0030268CrossRefPubMedPubMedCentral
34.
go back to reference Pattaraarchachai J, Rao C, Polprasert W, Porapakkham Y, Poa-in W, Singeverathum N, Lopez AD: Cause-specific mortality patterns among hospital deaths in Thailand: validating routine death certification. Popul Health Metr 2010, 8: 12. 10.1186/1478-7954-8-12CrossRefPubMedPubMedCentral Pattaraarchachai J, Rao C, Polprasert W, Porapakkham Y, Poa-in W, Singeverathum N, Lopez AD: Cause-specific mortality patterns among hospital deaths in Thailand: validating routine death certification. Popul Health Metr 2010, 8: 12. 10.1186/1478-7954-8-12CrossRefPubMedPubMedCentral
35.
go back to reference World Health Organization: Mortality: guidelines for certification and rules for coding. In International Statistical Classification of Diseases and Health Related Problems - Tenth Revision Volume 2: Instruction Manual. Geneva: World Health Organization; 1993:30-65. World Health Organization: Mortality: guidelines for certification and rules for coding. In International Statistical Classification of Diseases and Health Related Problems - Tenth Revision Volume 2: Instruction Manual. Geneva: World Health Organization; 1993:30-65.
36.
go back to reference World Health Organization: Special tabulation lists for mortality and morbidity; Mortality tabulation list 1. In International Statistical Classification of Diseases and Health Related Problems - Tenth Revision Volume 1. Geneva: World Health Organization; 1993:1207-10. World Health Organization: Special tabulation lists for mortality and morbidity; Mortality tabulation list 1. In International Statistical Classification of Diseases and Health Related Problems - Tenth Revision Volume 1. Geneva: World Health Organization; 1993:1207-10.
37.
go back to reference Murray CJL, Laakso T, Shibuya K, Hill K, Lopez AD: Can we achieve Millennium Development Goal 4? New analysis of country trends and forecasts of under-5 mortality to 2015. Lancet 2007, 370: 1040-54. 10.1016/S0140-6736(07)61478-0CrossRefPubMed Murray CJL, Laakso T, Shibuya K, Hill K, Lopez AD: Can we achieve Millennium Development Goal 4? New analysis of country trends and forecasts of under-5 mortality to 2015. Lancet 2007, 370: 1040-54. 10.1016/S0140-6736(07)61478-0CrossRefPubMed
39.
go back to reference Chandramohan D, Setel P, Quigley M: Effect of misclassification of causes of death in verbal autopsy: can it be adjusted. Int J Epidemiol 2001, 30: 509-514. 10.1093/ije/30.3.509CrossRefPubMed Chandramohan D, Setel P, Quigley M: Effect of misclassification of causes of death in verbal autopsy: can it be adjusted. Int J Epidemiol 2001, 30: 509-514. 10.1093/ije/30.3.509CrossRefPubMed
Metadata
Title
Cause-of-death ascertainment for deaths that occur outside hospitals in Thailand: application of verbal autopsy methods
Authors
Warangkana Polprasert
Chalapati Rao
Timothy Adair
Junya Pattaraarchachai
Yawarat Porapakkham
Alan D Lopez
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Population Health Metrics / Issue 1/2010
Electronic ISSN: 1478-7954
DOI
https://doi.org/10.1186/1478-7954-8-13

Other articles of this Issue 1/2010

Population Health Metrics 1/2010 Go to the issue