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Published in: Clinical Autonomic Research 6/2017

01-12-2017 | Short Communication

Carotid artery reactivity during sympathetic activation following acute resistance exercise

Authors: Kevin S. Heffernan, Wesley K. Lefferts, Eun Sun Yoon, Soo Hyun Park, Yong Hee Lee, Sae Young Jae

Published in: Clinical Autonomic Research | Issue 6/2017

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Abstract

Objective

Acute resistance exercise has been shown to reduce brachial endothelial function. Whether there are concomitant reductions in carotid endothelial function remains unexplored.

Methods

Cold pressor test–mediated vasodilation of the carotid artery was used to assess carotid endothelial function in 15 young and healthy participants (age 26 ± 1 years, body mass index 24 ± 1 kg/m2) after acute resistance exercise or an inactive time control condition.

Results

Acute resistance exercise had no effect on the cold pressor test–mediated vasodilation compared to time control (5.8 ± 0.8 vs 6.2 ± 0.9% dilation, p > 0.05).

Interpretation

Carotid endothelial function may not be compromised following acute resistance exercise in young healthy adults.
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Literature
1.
go back to reference Beyer AM, Durand MJ, Hockenberry J, Gamblin TC, Phillips SA, Gutterman DD (2014) An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles. Am J Physiol Heart Circ Physiol 307:H1587–H1593CrossRefPubMedPubMedCentral Beyer AM, Durand MJ, Hockenberry J, Gamblin TC, Phillips SA, Gutterman DD (2014) An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles. Am J Physiol Heart Circ Physiol 307:H1587–H1593CrossRefPubMedPubMedCentral
2.
go back to reference Black JM, Stohr EJ, Stone K, Pugh CJ, Stembridge M, Shave R, Esformes JI (2016) The effect of an acute bout of resistance exercise on carotid artery strain and strain rate. Physiol Rep 4:e12959 Black JM, Stohr EJ, Stone K, Pugh CJ, Stembridge M, Shave R, Esformes JI (2016) The effect of an acute bout of resistance exercise on carotid artery strain and strain rate. Physiol Rep 4:e12959
3.
go back to reference Dawson EA, Green DJ, Cable NT (1985) Thijssen DH (2013) Effects of acute exercise on flow-mediated dilatation in healthy humans. J Appl Physiol 115:1589–1598CrossRef Dawson EA, Green DJ, Cable NT (1985) Thijssen DH (2013) Effects of acute exercise on flow-mediated dilatation in healthy humans. J Appl Physiol 115:1589–1598CrossRef
4.
go back to reference Dawson EA, Whyte GP, Black MA, Jones H, Hopkins N, Oxborough D, Gaze D, Shave RE, Wilson M, George KP, Green DJ (2008) Changes in vascular and cardiac function after prolonged strenuous exercise in humans. J Appl Physiol (1985) 105:1562–1568 Dawson EA, Whyte GP, Black MA, Jones H, Hopkins N, Oxborough D, Gaze D, Shave RE, Wilson M, George KP, Green DJ (2008) Changes in vascular and cardiac function after prolonged strenuous exercise in humans. J Appl Physiol (1985) 105:1562–1568
5.
go back to reference DeVan AE, Anton MM, Cook JN, Neidre DB, Cortez-Cooper MY, Tanaka H (2005) Acute effects of resistance exercise on arterial compliance. J Appl Physiol 98:2287–2291CrossRefPubMed DeVan AE, Anton MM, Cook JN, Neidre DB, Cortez-Cooper MY, Tanaka H (2005) Acute effects of resistance exercise on arterial compliance. J Appl Physiol 98:2287–2291CrossRefPubMed
6.
go back to reference Gonzales JU, Thompson BC, Thistlethwaite JR, Scheuermann BW (2011) Association between exercise hemodynamics and changes in local vascular function following acute exercise. Appl Physiol Nutr Metab 36:137–144 Gonzales JU, Thompson BC, Thistlethwaite JR, Scheuermann BW (2011) Association between exercise hemodynamics and changes in local vascular function following acute exercise. Appl Physiol Nutr Metab 36:137–144
7.
go back to reference Heffernan KS, Collier SR, Kelly EE, Jae SY, Fernhall B (2007) Arterial stiffness and baroreflex sensitivity following bouts of aerobic and resistance exercise. Int J Sports Med 28:197–203CrossRefPubMed Heffernan KS, Collier SR, Kelly EE, Jae SY, Fernhall B (2007) Arterial stiffness and baroreflex sensitivity following bouts of aerobic and resistance exercise. Int J Sports Med 28:197–203CrossRefPubMed
8.
go back to reference Heffernan KS, Jae SY, Edwards DG, Kelly EE, Fernhall B (2007) Arterial stiffness following repeated Valsalva maneuvers and resistance exercise in young men. Appl Physiol Nutr Metab 32:257–264 Heffernan KS, Jae SY, Edwards DG, Kelly EE, Fernhall B (2007) Arterial stiffness following repeated Valsalva maneuvers and resistance exercise in young men. Appl Physiol Nutr Metab 32:257–264
9.
go back to reference Jurva JW, Phillips SA, Syed AQ, Syed AY, Pitt S, Weaver A, Gutterman DD (2006) The effect of exertional hypertension evoked by weight lifting on vascular endothelial function. J Am Coll Cardiol 48:588–589CrossRefPubMed Jurva JW, Phillips SA, Syed AQ, Syed AY, Pitt S, Weaver A, Gutterman DD (2006) The effect of exertional hypertension evoked by weight lifting on vascular endothelial function. J Am Coll Cardiol 48:588–589CrossRefPubMed
10.
go back to reference Kawano H, Tanimoto M, Yamamoto K, Sanada K, Gando Y, Tabata I, Higuchi M, Miyachi M (2008) Resistance training in men is associated with increased arterial stiffness and blood pressure but does not adversely affect endothelial function as measured by arterial reactivity to the cold pressor test. Exp Physiol 93:296–302CrossRefPubMed Kawano H, Tanimoto M, Yamamoto K, Sanada K, Gando Y, Tabata I, Higuchi M, Miyachi M (2008) Resistance training in men is associated with increased arterial stiffness and blood pressure but does not adversely affect endothelial function as measured by arterial reactivity to the cold pressor test. Exp Physiol 93:296–302CrossRefPubMed
11.
go back to reference Kuvin JT, Sidhu M, Patel AR, Sliney KA, Pandian NG, Karas RH (2005) Pulse pressure and peripheral arterial vasoreactivity. J Hum Hypertens 19:501–502CrossRefPubMed Kuvin JT, Sidhu M, Patel AR, Sliney KA, Pandian NG, Karas RH (2005) Pulse pressure and peripheral arterial vasoreactivity. J Hum Hypertens 19:501–502CrossRefPubMed
12.
go back to reference Lamping KG, Dole WP (1987) Acute hypertension selectively potentiates constrictor responses of large coronary arteries to serotonin by altering endothelial function in vivo. Circ Res 61:904–913CrossRefPubMed Lamping KG, Dole WP (1987) Acute hypertension selectively potentiates constrictor responses of large coronary arteries to serotonin by altering endothelial function in vivo. Circ Res 61:904–913CrossRefPubMed
13.
go back to reference Lefferts WK, Augustine JA, Heffernan KS (2014) Effect of acute resistance exercise on carotid artery stiffness and cerebral blood flow pulsatility. Front Physiol 5:101CrossRefPubMedPubMedCentral Lefferts WK, Augustine JA, Heffernan KS (2014) Effect of acute resistance exercise on carotid artery stiffness and cerebral blood flow pulsatility. Front Physiol 5:101CrossRefPubMedPubMedCentral
14.
go back to reference Malik AR, Kondragunta V, Kullo IJ (2008) Forearm vascular reactivity and arterial stiffness in asymptomatic adults from the community. Hypertension 51:1512–1518CrossRefPubMedPubMedCentral Malik AR, Kondragunta V, Kullo IJ (2008) Forearm vascular reactivity and arterial stiffness in asymptomatic adults from the community. Hypertension 51:1512–1518CrossRefPubMedPubMedCentral
15.
go back to reference Millgard J, Lind L (1998) Acute hypertension impairs endothelium-dependent vasodilation. Clin Sci (Lond) 94:601–607CrossRef Millgard J, Lind L (1998) Acute hypertension impairs endothelium-dependent vasodilation. Clin Sci (Lond) 94:601–607CrossRef
16.
go back to reference Rubenfire M, Rajagopalan S, Mosca L (2000) Carotid artery vasoreactivity in response to sympathetic stress correlates with coronary disease risk and is independent of wall thickness. J Am Coll Cardiol 36:2192–2197CrossRefPubMed Rubenfire M, Rajagopalan S, Mosca L (2000) Carotid artery vasoreactivity in response to sympathetic stress correlates with coronary disease risk and is independent of wall thickness. J Am Coll Cardiol 36:2192–2197CrossRefPubMed
17.
go back to reference Sugawara J, Komine H, Hayashi K, Yoshizawa M, Yokoi T, Otsuki T, Shimojo N, Miyauchi T, Maeda S, Tanaka H (2007) Effect of systemic nitric oxide synthase inhibition on arterial stiffness in humans. Hypertens Res 30:411–415 Sugawara J, Komine H, Hayashi K, Yoshizawa M, Yokoi T, Otsuki T, Shimojo N, Miyauchi T, Maeda S, Tanaka H (2007) Effect of systemic nitric oxide synthase inhibition on arterial stiffness in humans. Hypertens Res 30:411–415
18.
go back to reference Tan Y, Tseng PO, Wang D, Zhang H, Hunter K, Hertzberg J, Stenmark KR, Tan W (2014) Stiffening-induced high pulsatility flow activates endothelial inflammation via a TLR2/NF-kappaB pathway. PLoS One 9:e102195CrossRefPubMedPubMedCentral Tan Y, Tseng PO, Wang D, Zhang H, Hunter K, Hertzberg J, Stenmark KR, Tan W (2014) Stiffening-induced high pulsatility flow activates endothelial inflammation via a TLR2/NF-kappaB pathway. PLoS One 9:e102195CrossRefPubMedPubMedCentral
19.
go back to reference Thijssen DH, Rowley N, Padilla J, Simmons GH, Laughlin MH, Whyte G, Cable NT, Green DJ (2011) Relationship between upper and lower limb conduit artery vasodilator function in humans. J Appl Physiol 111:244–250CrossRefPubMedPubMedCentral Thijssen DH, Rowley N, Padilla J, Simmons GH, Laughlin MH, Whyte G, Cable NT, Green DJ (2011) Relationship between upper and lower limb conduit artery vasodilator function in humans. J Appl Physiol 111:244–250CrossRefPubMedPubMedCentral
20.
go back to reference Tousoulis D, Davies G, Tentolouris C, Crake T, Toutouzas P (1997) Inhibition of nitric oxide synthesis during the cold pressor test in patients with coronary artery disease. Am J Cardiol 79:1676–1679CrossRefPubMed Tousoulis D, Davies G, Tentolouris C, Crake T, Toutouzas P (1997) Inhibition of nitric oxide synthesis during the cold pressor test in patients with coronary artery disease. Am J Cardiol 79:1676–1679CrossRefPubMed
21.
go back to reference Townsend RR, Wilkinson IB, Schiffrin EL, Avolio AP, Chirinos JA, Cockcroft JR, Heffernan KS, Lakatta EG, McEniery CM, Mitchell GF, Najjar SS, Nichols WW, Urbina EM, Weber T (2015) Recommendations for improving and standardizing vascular research on arterial stiffness: a scientific statement from the American Heart Association. Hypertension 66:698–722CrossRefPubMedPubMedCentral Townsend RR, Wilkinson IB, Schiffrin EL, Avolio AP, Chirinos JA, Cockcroft JR, Heffernan KS, Lakatta EG, McEniery CM, Mitchell GF, Najjar SS, Nichols WW, Urbina EM, Weber T (2015) Recommendations for improving and standardizing vascular research on arterial stiffness: a scientific statement from the American Heart Association. Hypertension 66:698–722CrossRefPubMedPubMedCentral
22.
go back to reference van Mil AC, Hartman Y, van Oorschot F, Heemels A, Bax N, Dawson EA, Hopkins N, Hopman MT, Green DJ, Oxborough DL, Thijssen DH (2017) Correlation of carotid artery reactivity with cardiovascular risk factors and coronary artery vasodilator responses in asymptomatic, healthy volunteers. J Hypertens 35:1026–1034CrossRefPubMed van Mil AC, Hartman Y, van Oorschot F, Heemels A, Bax N, Dawson EA, Hopkins N, Hopman MT, Green DJ, Oxborough DL, Thijssen DH (2017) Correlation of carotid artery reactivity with cardiovascular risk factors and coronary artery vasodilator responses in asymptomatic, healthy volunteers. J Hypertens 35:1026–1034CrossRefPubMed
23.
go back to reference Yoon ES, Jung SJ, Cheun SK, Oh YS, Kim SH, Jae SY (2010) Effects of acute resistance exercise on arterial stiffness in young men. Korean Circ J 40:16–22CrossRefPubMedPubMedCentral Yoon ES, Jung SJ, Cheun SK, Oh YS, Kim SH, Jae SY (2010) Effects of acute resistance exercise on arterial stiffness in young men. Korean Circ J 40:16–22CrossRefPubMedPubMedCentral
Metadata
Title
Carotid artery reactivity during sympathetic activation following acute resistance exercise
Authors
Kevin S. Heffernan
Wesley K. Lefferts
Eun Sun Yoon
Soo Hyun Park
Yong Hee Lee
Sae Young Jae
Publication date
01-12-2017
Publisher
Springer Berlin Heidelberg
Published in
Clinical Autonomic Research / Issue 6/2017
Print ISSN: 0959-9851
Electronic ISSN: 1619-1560
DOI
https://doi.org/10.1007/s10286-017-0469-8

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