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BMC Oral Health

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Open Access 01-12-2020 | Caries | Research article

Remineralising effect of 45S5 bioactive glass on artificial caries in dentine

Authors: Qiong Wu, May Lei Mei, Xin Wu, Shuya Shi, Yuting Xu, Chun Hung Chu, Yaming Chen

Published in: BMC Oral Health | Issue 1/2020

Abstract

Background

This study investigated the remineralisation effect of bioactive glass on artificial dentine caries.

Methods

Dentine disks with artificial caries were treated with bioactive glass (group BAG), casein phosphopeptide–amorphous calcium phosphate (CPP-ACP) (group CPP-ACP), sodium fluoride glycerol (group F) or deionized water (group W). All disks were subjected to pH cycling for 28 days subsequently. The topography, microhardness and remineralisation depth of the dentine carious lesion were assessed by atomic force microscopy (AFM), microhardness testing and confocal laser scanning microscope (CLSM), respectively.

Results

AFM images indicated mineral depositions on the surface of the carious lesion in group BAG. The changes of Vickers hardness number (ΔVHN, mean ± SD) after pH cycling were 9.67 ± 3.60, 6.06 ± 3.83, 5.00 ± 2.19 and − 1.90 ± 2.09 (p < 0.001) in group BAG, group CPP-ACP, group F and group W, respectively. The remineralisation depth (mean ± SD) of the carious lesion in group BAG, group CPP-ACP, group F and group W were 165 ± 11 μm, 111 ± 11 μm, 75 ± 6 μm and 0 μm (p < 0.001), respectively.

Conclusion

Bioactive glass possessed a promising remineralisation effect on artificial dentine caries and could be a therapeutic choice for caries management.

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Title: Remineralising effect of 45S5 bioactive glass on artificial caries in dentine
Authors: Qiong Wu
May Lei Mei
Xin Wu
Shuya Shi
Yuting Xu
Chun Hung Chu
Yaming Chen
Publication date: 01-12-2020
Publisher: BioMed Central
Keyword: Caries
Published in: BMC Oral Health / Issue 1/2020
Electronic ISSN: 1472-6831
DOI: https://doi.org/10.1186/s12903-020-1038-4

At a glance: The STEP trials

Springer Medicine

Remineralising effect of 45S5 bioactive glass on artificial caries in dentine

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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