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Supportive Care in Cancer

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01-09-2019 | Care | Original Article

The association between patients’ perceived continuity of care and beliefs about oral anticancer treatment

Authors: Orit Cohen Castel, Efrat Shadmi, Lital Keinan–Boker, Tal Granot, Khaled Karkabi, Efrat Dagan

Published in: Supportive Care in Cancer | Issue 9/2019

Abstract

Purpose

To explore factors associated with necessity beliefs and concerns among patients receiving oral anticancer therapy (OACT) and, specifically, to examine the relationship between continuity of care (COC) and patients’ beliefs about OACT.

Methods

A cross-sectional study was conducted among patients from four oncology centers receiving OACT (either targeted, hormonal, or chemotherapy). Two months after OACT initiation, patients were asked to participate in a face-to-face or telephone survey. The Beliefs about Medicines Questionnaire was used to examine patients’ perceptions of their personal necessity for OACT and concerns about potential adverse effects. The Nijmegen Continuity Questionnaire was used to assess patients’ perceived COC. Data on clinical characteristics were collected from medical records.

Results

Participants’ beliefs about OACT necessity (n = 91) were found to be associated with COC within the oncology team, and with COC between the oncology specialist and the primary care physicians (β = 0.27, p = 0.003; β = 0.22, p = 0.02, respectively), beyond age, depression, and cancer type (ΔR² = 0.14, p < 0.001). Additionally, the difference between participants’ beliefs about OACT necessity and their OACT-related concerns was associated with COC within the oncology team (β = 0.30, p = 0.001), beyond age, income, family status, and cancer type (ΔR² = 0.09, p = 0.001).

Conclusions

This study shows that cancer patients’ perceptions about the COC between care providers are related to their beliefs about OACT necessity, thus providing evidence for the importance of health care delivery approaches that support COC within the oncology team and between the oncology specialist and the primary care physician.

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Timmers L, Beckeringh JJ, van Herk-Sukel MP, Boven E, Hugtenburg JG (2012) Use and costs of oral anticancer agents in the Netherlands in the period 2000–2008. Pharmacoepidemiol Drug Saf 21(10):1036–1044. https://doi.org/10.1002/pds.2225 CrossRefPubMed

Schneider SM, Hess K, Gosselin T (2011) Interventions to promote adherence with oral agents. Semin Oncol Nurs 27(2):133–141. https://doi.org/10.1016/j.soncn.2011.02.005 CrossRefPubMedPubMedCentral

Liu G, Franssen E, Fitch MI, Warner E (1997) Patient preferences for oral versus intravenous palliative chemotherapy. J Clin Oncol 15(1):110–115CrossRefPubMed

Seal BS, Anderson S, Shermock KM (2016) Factors associated with adherence rates for oral and intravenous anticancer therapy in commercially insured patients with metastatic colon cancer. J Managed Care Specialty Pharm 22(3):227–235. https://doi.org/10.18553/jmcp.2016.22.3.227 CrossRef

Kripalani S, LeFevre F, Phillips CO, Williams MV, Basaviah P, Baker DW (2007) Deficits in communication and information transfer between hospital-based and primary care physicians: implications for patient safety and continuity of care. JAMA 297(8):831–841. https://doi.org/10.1001/jama.297.8.831 CrossRefPubMed

Ganesan P, Sagar TG, Dubashi B, Rajendranath R, Kannan K, Cyriac S, Nandennavar M (2011) Nonadherence to Imatinib adversely affects event free survival in chronic phase chronic myeloid leukemia. Am J Hematol 86(6):471–474. https://doi.org/10.1002/ajh.22019 CrossRefPubMed

Makubate B, Donnan PT, Dewar JA, Thompson AM, McCowan C (2013) Cohort study of adherence to adjuvant endocrine therapy, breast cancer recurrence and mortality. Br J Cancer 108(7):1515–1524. https://doi.org/10.1038/bjc.2013.116 CrossRefPubMedPubMedCentral

Verbrugghe M, Verhaeghe S, Lauwaert K, Beeckman D, Van Hecke A (2013) Determinants and associated factors influencing medication adherence and persistence to oral anticancer drugs: a systematic review. Cancer Treatment Rev 39(6):610–621. https://doi.org/10.1016/j.ctrv.2012.12.014 CrossRef

Mathes T, Pieper D, Antoine SL, Eikermann M (2014) Adherence influencing factors in patients taking oral anticancer agents: a systematic review. Cancer Epidemiol 38:214–226. https://doi.org/10.1016/j.canep.2014.03.012 CrossRefPubMed

10.

Lin C, Clark R, Tu P, Bosworth HB, Zullig LL (2017) Breast cancer oral anti-cancer medication adherence: a systematic review of psychosocial motivators and barriers. Breast Cancer Res Treatment 165(2):247–260. https://doi.org/10.1007/s10549-017-4317-2 CrossRef

11.

Janz NK, Becker MH (1984) The health belief model: a decade later. Health Ed Quart 11(1):1–47. https://doi.org/10.1177/109019818401100101 CrossRef

12.

Holmes EAF, Hughes DA, Morrison VL (2014) Predicting adherence to medications using health psychology theories: a systematic review of 20 years of empirical research. Value Health 17(8):863–876. https://doi.org/10.1016/j.jval.2014.08.2671 CrossRefPubMed

13.

Lehane E, McCarthy G (2007) An examination of the intentional and unintentional aspects of medication non-adherence in patients diagnosed with hypertension. J Clin Nurs 16(4):698–706. https://doi.org/10.1111/j.1365-2702.2005.01538.x CrossRefPubMed

14.

Gadkari AS, McHorney CA (2012) Unintentional non-adherence to chronic prescription medications: how unintentional is it really? BMC Health Serv Res 12:98. https://doi.org/10.1186/1472-6963-12-98 CrossRefPubMedPubMedCentral

15.

Horne R, Weinman J (1999) Patients’ beliefs about prescribed medicines and their role in adherence to treatment in chronic physical illness. J Psychosom Res 47(6):555–567CrossRefPubMed

16.

Horne R, Chapman SC, Parham R, Freemantle N, Forbes A, Cooper V (2013) Understanding patients’ adherence-related beliefs about medicines prescribed for long-term conditions: a meta-analytic review of the necessity-concerns framework. PLoS One 8(12):e80633. https://doi.org/10.1371/journal.pone.0080633 CrossRefPubMedPubMedCentral

17.

Foot H, La Caze A, Gujral G, Cottrell N (2016) The necessity-concerns framework predicts adherence to medication in multiple illness conditions: a meta-analysis. Patient Educ Couns 99(5):706–717. https://doi.org/10.1016/j.pec.2015.11.004 CrossRefPubMed

18.

Butler JA, Peveler RC, Roderick P, Smith PW, Horne R, Mason JC (2004) Modifiable risk factors for non-adherence to immunosuppressants in renal transplant recipients: a cross-sectional study. Nephrol Dial Transplant 19(12):3144–3149. https://doi.org/10.1093/ndt/gfh505 CrossRefPubMed

19.

Jacob Arriola KR, Mason TA, Bannon KA, Holmes C, Powell CL, Horne K, O’Regan R (2014) Modifiable risk factors for adherence to adjuvant endocrine therapy among breast cancer patients. Patient Educ Couns 95(1):98–103. https://doi.org/10.1016/j.pec.2013.12.019 CrossRefPubMed

20.

Haggerty JL, Reid RJ, Freeman GK, Starfield BH, Adair CE, McKendry R (2003) Continuity of care: a multidisciplinary review. BMJ 327(7425):1219–1221. https://doi.org/10.1136/bmj.327.7425.1219 CrossRefPubMedPubMedCentral

21.

Dossett LA, Hudson JN, Morris AM, Lee MC, Roetzheim RG, Fetters MD, Quinn GP (2017) The primary care provider (PCP)-cancer specialist relationship: systematic review and mixed-methods meta-synthesis. CA Cancer J Clin 67(2):156–169. https://doi.org/10.3322/caac.21385 CrossRefPubMed

22.

Uijen AA, Schers HJ, Schellevis FG, Mokkink HG, van Weel C, van den Bosch WJ (2012) Measuring continuity of care: psychometric properties of the Nijmegen Continuity Questionnaire. Br J Gen Pract 62(600):e949–e957. https://doi.org/10.3399/bjgp12X652364 CrossRefPubMedPubMedCentral

23.

Snyder CF, Earle CC, Herbert RJ, Neville BA, Blackford AL, Frick KD (2008) Trends in follow-up and preventive care for colorectal cancer survivors. J Gen Int Med 23(3):254–259. https://doi.org/10.1007/s11606-007-0497-5 CrossRef

24.

Husain A, Barbera L, Howell D, Moineddin R, Bezjak A, Sussman J (2013) Advanced lung cancer patients’ experience with continuity of care and supportive care needs. Support Care Cancer 21(5):1351–1358. https://doi.org/10.1007/s00520-012-1673-7 CrossRefPubMed

25.

Weingart SN, Brown E, Bach PB, Eng K, Johnson SA, Kuzel TM, Langbaum TS, Leedy RD, Muller RJ, Newcomer LN, O’Brien S, Reinke D, Rubino M, Saltz L, Walters RS (2008) NCCN task force report: oral chemotherapy. J Natl Compr Cancer Netw 6(Suppl 3):S1–S14

26.

Cohen J (1992) A power primer. Psychol Bull 112(1):155–159CrossRef

27.

Channa Y, Shabo V (2012) Israel household expenditure survey and income survey 2010. Central Bureau of Statistics.http://www.cbs.gov.il/www/statistical/home10_e.pdf. Accessed 8 Sept 2018

28.

Geulayov G, Jungerman T, Moses S, Friedman N, Miron R, Gross R (2009) Assessing the psychometric properties of the mood module of the Patient Health Questionnaire in primary care in Israel. Isr J Psychiatry Relat Sci 46:36

29.

Bhattacharya D, Easthall C, Willoughby KA, Small M, Watson S (2012) Capecitabine non-adherence: exploration of magnitude, nature and contributing factors. J Oncol Pharm Pract 18(3):333–342. https://doi.org/10.1177/1078155211436022 CrossRefPubMed

30.

Horne R, Weinman J, Hankins M (1999) The beliefs about medicines questionnaire: the development and evaluation of a new method for assessing the cognitive representation of medication. Psychol Health 14(1):1–24. https://doi.org/10.1080/08870449908407311 CrossRef

31.

Uijen AA, Schellevis FG, van den Bosch WJ, Mokkink HG, van Weel C, Schers HJ (2011) Nijmegen Continuity Questionnaire: development and testing of a questionnaire that measures continuity of care. J Clin Epidemiol 64(12):1391–1399. https://doi.org/10.1016/j.jclinepi.2011.03.006 CrossRefPubMed

32.

Cohen Castel O, Dagan E, Keinan-Boker L, Shadmi E (2018) Reliability and validity of the Hebrew version of the Nijmegen Continuity Questionnaire for measuring patients’ perceived continuity of care in oral anticancer therapy. Eur J Cancer Care (Engl) 27(6):e12913. https://doi.org/10.1111/ecc.12913 CrossRef

33.

Kroenke K, Spitzer RL, Williams JB (2001) The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med 16(9):606–613CrossRefPubMedPubMedCentral

34.

Foglino S, Bravi F, Carretta E, Fantini MP, Dobrow MJ, Brown AD (2016) The relationship between integrated care and cancer patient experience: a scoping review of the evidence. Health Policy 120(1):55–63. https://doi.org/10.1016/j.healthpol.2015.12.004 CrossRefPubMed

35.

Komatsu H, Nakayama K, Togari T, Suzuki K, Hayashi N, Murakami Y, Iioka Y, Osaka W, Yagasaki K, Nakamura S, Neumann J, Ueno NT (2011) Information sharing and case conference among the multidisciplinary team improve patients’ perceptions of care. Open Nurs J 5:79–85. https://doi.org/10.2174/1874434601105010079 CrossRefPubMedPubMedCentral

36.

Nielsen JD, Palshof T, Mainz J, Jensen AB, Olesen F (2003) Randomised controlled trial of a shared care programme for newly referred cancer patients: bridging the gap between general practice and hospital. Qual Saf Health Care 12(4):263–272CrossRefPubMedPubMedCentral

37.

Timmers L, Boons CC, Mangnus D, Van de Ven PM, Van den Berg PH, Beeker A, Swart EL, Honeywell RJ, Peters GJ, Boven E, Hugtenburg JG (2016) Adherence and patients’ experiences with the use of capecitabine in daily practice. Front Pharmacol 7:310. https://doi.org/10.3389/fphar.2016.00310 CrossRefPubMedPubMedCentral

Title: The association between patients’ perceived continuity of care and beliefs about oral anticancer treatment
Authors: Orit Cohen Castel
Efrat Shadmi
Lital Keinan–Boker
Tal Granot
Khaled Karkabi
Efrat Dagan
Publication date: 01-09-2019
Publisher: Springer Berlin Heidelberg
Keyword: Care
Published in: Supportive Care in Cancer / Issue 9/2019
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-019-04668-6

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Abstract

Purpose

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Conclusions

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