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Published in: Current Anesthesiology Reports 4/2019

01-12-2019 | Care | Geriatric Anesthesia (S Akhtar, Section Editor)

Perioperative Acute Care of Older Patients Living with Frailty

Authors: Janny Xue Chen Ke, David B. MacDonald, Daniel I. McIsaac

Published in: Current Anesthesiology Reports | Issue 4/2019

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Abstract

Purpose of Review

Frailty has been independently linked to adverse postoperative outcomes including increased morbidity, mortality, health resource use, and disability. We discuss the data underlying these associations, as well as literature supporting perioperative frailty assessment and perioperative management strategies, with a focus on older people with frailty undergoing elective, non-cardiac surgery.

Recent Findings

Perioperative interventions tested to improve outcomes for older people with frailty are limited; interventions proven to improve outcomes are even more rare. Current evidence-based strategies include exercise therapy, preoperative identification and communication of frailty status, and multidisciplinary geriatric focused care. No specific intraoperative strategy exists to impact outcomes for people with frailty.

Summary

Older people with frailty are vulnerable to adverse outcomes following surgery. However, significant knowledge gaps exist with respect to encouraging routine assessment of frailty and development of effective perioperative interventions. Anesthesiologists are uniquely poised to facilitate the multidisciplinary perioperative care of frail patients. High-quality trials are needed to elucidate patient-centered outcomes, risk prediction, shared decision-making, and individualized perioperative interventions in older patients with frailty.
Literature
1.
go back to reference Beard JR, Officer A, de Carvalho IA, Sadana R, Pot AM, Michel J-P, et al. The World report on ageing and health: a policy framework for healthy ageing. Lancet Lond Engl. 2016;387(10033):2145–54. Beard JR, Officer A, de Carvalho IA, Sadana R, Pot AM, Michel J-P, et al. The World report on ageing and health: a policy framework for healthy ageing. Lancet Lond Engl. 2016;387(10033):2145–54.
4.
go back to reference Kwok AC, Semel ME, Lipsitz SR, Bader AM, Barnato AE, Gawande AA, et al. The intensity and variation of surgical care at the end of life: a retrospective cohort study. Lancet. 2011;378(9800):1408–13.PubMed Kwok AC, Semel ME, Lipsitz SR, Bader AM, Barnato AE, Gawande AA, et al. The intensity and variation of surgical care at the end of life: a retrospective cohort study. Lancet. 2011;378(9800):1408–13.PubMed
5.
go back to reference Wijeysundera DN, Beattie WS, Karkouti K, Neuman MD, Austin PC, Laupacis A. Association of echocardiography before major elective non-cardiac surgery with postoperative survival and length of hospital stay: population based cohort study. BMJ. 2011;342:d3695.PubMedPubMedCentral Wijeysundera DN, Beattie WS, Karkouti K, Neuman MD, Austin PC, Laupacis A. Association of echocardiography before major elective non-cardiac surgery with postoperative survival and length of hospital stay: population based cohort study. BMJ. 2011;342:d3695.PubMedPubMedCentral
6.
go back to reference King A, Bottle A, Faiz O, Aylin P. Investigating adverse event free admissions in Medicare inpatients as a patient safety indicator. Ann Surg. 2017;265(5):910–5.PubMed King A, Bottle A, Faiz O, Aylin P. Investigating adverse event free admissions in Medicare inpatients as a patient safety indicator. Ann Surg. 2017;265(5):910–5.PubMed
7.
go back to reference McIsaac DI, Taljaard M, Bryson GL, Beaulé PE, Gagné S, Hamilton G, et al. Frailty as a predictor of death or new disability after surgery: a prospective cohort study. Ann Surg. 2018;24. (PMID:30048320) McIsaac DI, Taljaard M, Bryson GL, Beaulé PE, Gagné S, Hamilton G, et al. Frailty as a predictor of death or new disability after surgery: a prospective cohort study. Ann Surg. 2018;24. (PMID:30048320)
8.
go back to reference Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56.PubMed Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56.PubMed
9.
go back to reference Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ Can Med Assoc J J Assoc Medicale Can. 2005;173(5):489–95. Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ Can Med Assoc J J Assoc Medicale Can. 2005;173(5):489–95.
10.
go back to reference Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol Ser A. 2004;59(3):M255–63. Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol Ser A. 2004;59(3):M255–63.
11.
go back to reference Robinson TN, Walston JD, Brummel NE, Deiner S, Brown CH, Kennedy M, et al. Frailty for surgeons: review of a National Institute on Aging Conference on Frailty for Specialists. J Am Coll Surg. 2015;221(6):1083–92.PubMedPubMedCentral Robinson TN, Walston JD, Brummel NE, Deiner S, Brown CH, Kennedy M, et al. Frailty for surgeons: review of a National Institute on Aging Conference on Frailty for Specialists. J Am Coll Surg. 2015;221(6):1083–92.PubMedPubMedCentral
12.
go back to reference Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K. A standard procedure for creating a frailty index. BMC Geriatr. 2008;8(1):24.PubMedPubMedCentral Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K. A standard procedure for creating a frailty index. BMC Geriatr. 2008;8(1):24.PubMedPubMedCentral
13.
go back to reference Mitnitski AB, Mogilner AJ, Rockwood K. Accumulation of deficits as a proxy measure of aging. ScientificWorldJournal. 2001;1:323–36.PubMedPubMedCentral Mitnitski AB, Mogilner AJ, Rockwood K. Accumulation of deficits as a proxy measure of aging. ScientificWorldJournal. 2001;1:323–36.PubMedPubMedCentral
14.
go back to reference Dent E, Kowal P, Hoogendijk EO. Frailty measurement in research and clinical practice: a review. Eur J Intern Med. 2016;31:3–10.PubMed Dent E, Kowal P, Hoogendijk EO. Frailty measurement in research and clinical practice: a review. Eur J Intern Med. 2016;31:3–10.PubMed
15.
go back to reference Rodríguez-Mañas L, Féart C, Mann G, Viña J, Chatterji S, Chodzko-Zajko W, et al. Searching for an operational definition of frailty: a Delphi method based consensus statement: the frailty operative definition-consensus conference project. J Gerontol A Biol Sci Med Sci. 2013;68(1):62–7.PubMed Rodríguez-Mañas L, Féart C, Mann G, Viña J, Chatterji S, Chodzko-Zajko W, et al. Searching for an operational definition of frailty: a Delphi method based consensus statement: the frailty operative definition-consensus conference project. J Gerontol A Biol Sci Med Sci. 2013;68(1):62–7.PubMed
16.
go back to reference Gale CR, Cooper C, Aihie SA. Prevalence of frailty and disability: findings from the English Longitudinal Study of Ageing. Age Ageing. 2015;44(1):162–5.PubMed Gale CR, Cooper C, Aihie SA. Prevalence of frailty and disability: findings from the English Longitudinal Study of Ageing. Age Ageing. 2015;44(1):162–5.PubMed
18.
go back to reference Wilkes JG, Evans JL, Prato BS, Hess SA, MacGillivray DC, Fitzgerald TL. Frailty cost: economic impact of frailty in the elective surgical patient. J Am Coll Surg. 2019;228(6):861–70.PubMed Wilkes JG, Evans JL, Prato BS, Hess SA, MacGillivray DC, Fitzgerald TL. Frailty cost: economic impact of frailty in the elective surgical patient. J Am Coll Surg. 2019;228(6):861–70.PubMed
19.
go back to reference McIsaac DI, Taljaard M, Bryson GL, Beaule PE, Gagne S, Hamilton G, et al. Comparative assessment of two frailty instruments for risk-stratification in elderly surgical patients: study protocol for a prospective cohort study. BMC Anesthesiol. 2016;16(1):111.PubMedPubMedCentral McIsaac DI, Taljaard M, Bryson GL, Beaule PE, Gagne S, Hamilton G, et al. Comparative assessment of two frailty instruments for risk-stratification in elderly surgical patients: study protocol for a prospective cohort study. BMC Anesthesiol. 2016;16(1):111.PubMedPubMedCentral
20.
go back to reference Beggs T, Sepehri A, Szwajcer A, Tangri N, Arora RC. Frailty and perioperative outcomes: a narrative review. Can J Anaesth J Can Anesth. 2015;62(2):143–57. Beggs T, Sepehri A, Szwajcer A, Tangri N, Arora RC. Frailty and perioperative outcomes: a narrative review. Can J Anaesth J Can Anesth. 2015;62(2):143–57.
21.
go back to reference Hewitt J, Carter B, McCarthy K, Pearce L, Law J, Wilson FV, et al. Frailty predicts mortality in all emergency surgical admissions regardless of age. An observational study. Age Ageing. 2019;48(3):388–94.PubMed Hewitt J, Carter B, McCarthy K, Pearce L, Law J, Wilson FV, et al. Frailty predicts mortality in all emergency surgical admissions regardless of age. An observational study. Age Ageing. 2019;48(3):388–94.PubMed
22.
go back to reference • Sandini M, Pinotti E, Persico I, Picone D, Bellelli G, Gianotti L. Systematic review and meta-analysis of frailty as a predictor of morbidity and mortality after major abdominal surgery. BJS Open. 2017;1(5):128–37 Summary of evidence on the link behind frailty and adverse outcomes for patients undergoing major abdominal surgery. PubMedPubMedCentral • Sandini M, Pinotti E, Persico I, Picone D, Bellelli G, Gianotti L. Systematic review and meta-analysis of frailty as a predictor of morbidity and mortality after major abdominal surgery. BJS Open. 2017;1(5):128–37 Summary of evidence on the link behind frailty and adverse outcomes for patients undergoing major abdominal surgery. PubMedPubMedCentral
23.
go back to reference Oakland K, Nadler R, Cresswell L, Jackson D, Coughlin P. Systematic review and meta-analysis of the association between frailty and outcome in surgical patients. Ann R Coll Surg Engl. 2016;98(2):80–5.PubMedPubMedCentral Oakland K, Nadler R, Cresswell L, Jackson D, Coughlin P. Systematic review and meta-analysis of the association between frailty and outcome in surgical patients. Ann R Coll Surg Engl. 2016;98(2):80–5.PubMedPubMedCentral
24.
go back to reference • Watt J, Tricco AC, Talbot-Hamon C, Pham B, Rios P, Grudniewicz A, et al. Identifying older adults at risk of delirium following elective surgery: a systematic review and meta-analysis. J Gen Intern Med. 2018;33(4):500–9 Summary of the evidence behind predictors of postoperative delirium. PubMedPubMedCentral • Watt J, Tricco AC, Talbot-Hamon C, Pham B, Rios P, Grudniewicz A, et al. Identifying older adults at risk of delirium following elective surgery: a systematic review and meta-analysis. J Gen Intern Med. 2018;33(4):500–9 Summary of the evidence behind predictors of postoperative delirium. PubMedPubMedCentral
25.
go back to reference McIsaac DI, Beaulé PE, Bryson GL, Van Walraven C. The impact of frailty on outcomes and healthcare resource usage after total joint arthroplasty: a population-based cohort study. Bone Jt J. 2016;98-B(6):799–805. McIsaac DI, Beaulé PE, Bryson GL, Van Walraven C. The impact of frailty on outcomes and healthcare resource usage after total joint arthroplasty: a population-based cohort study. Bone Jt J. 2016;98-B(6):799–805.
26.
go back to reference Mrdutt MM, Papaconstantinou HT, Robinson BD, Bird ET, Isbell CL. Preoperative frailty and surgical outcomes across diverse surgical subspecialties in a large health care system. J Am Coll Surg. 2019;228(4):482–90.PubMed Mrdutt MM, Papaconstantinou HT, Robinson BD, Bird ET, Isbell CL. Preoperative frailty and surgical outcomes across diverse surgical subspecialties in a large health care system. J Am Coll Surg. 2019;228(4):482–90.PubMed
27.
go back to reference Chow WB, Rosenthal RA, Merkow RP, Ko CY, Esnaola NF. American College of Surgeons National Surgical Quality Improvement Program, et al. Optimal preoperative assessment of the geriatric surgical patient: a best practices guideline from the American College of Surgeons National Surgical Quality Improvement Program and the American Geriatrics Society. J Am Coll Surg. 2012;215(4):453–66.PubMed Chow WB, Rosenthal RA, Merkow RP, Ko CY, Esnaola NF. American College of Surgeons National Surgical Quality Improvement Program, et al. Optimal preoperative assessment of the geriatric surgical patient: a best practices guideline from the American College of Surgeons National Surgical Quality Improvement Program and the American Geriatrics Society. J Am Coll Surg. 2012;215(4):453–66.PubMed
28.
go back to reference Griffiths R, Beech F, Brown A, Dhesi J, Foo I, Goodall J, et al. Peri-operative care of the elderly 2014: Association of Anaesthetists of Great Britain and Ireland. Anaesthesia. 2014;69(Suppl 1):81–98.PubMed Griffiths R, Beech F, Brown A, Dhesi J, Foo I, Goodall J, et al. Peri-operative care of the elderly 2014: Association of Anaesthetists of Great Britain and Ireland. Anaesthesia. 2014;69(Suppl 1):81–98.PubMed
29.
go back to reference •• Alvarez-Nebreda ML, Bentov N, Urman RD, Setia S, Huang JC-S, Pfeifer K, et al. Recommendations for preoperative management of frailty from the Society for Perioperative Assessment and Quality Improvement (SPAQI). J Clin Anesth. 2018;47:33–42 Interdisciplinary consensus guideline on the perioperative care of patients living with frailty. PubMed •• Alvarez-Nebreda ML, Bentov N, Urman RD, Setia S, Huang JC-S, Pfeifer K, et al. Recommendations for preoperative management of frailty from the Society for Perioperative Assessment and Quality Improvement (SPAQI). J Clin Anesth. 2018;47:33–42 Interdisciplinary consensus guideline on the perioperative care of patients living with frailty. PubMed
30.
go back to reference • Cooper Z, Rogers SO, Ngo L, Guess J, Schmitt E, Jones RN, et al. Comparison of frailty measures as predictors of outcomes after orthopedic surgery. J Am Geriatr Soc. 2016;64(12):2464–71 A comparison of the Frailty Phenotype and Frailty Index. PubMedPubMedCentral • Cooper Z, Rogers SO, Ngo L, Guess J, Schmitt E, Jones RN, et al. Comparison of frailty measures as predictors of outcomes after orthopedic surgery. J Am Geriatr Soc. 2016;64(12):2464–71 A comparison of the Frailty Phenotype and Frailty Index. PubMedPubMedCentral
31.
go back to reference Dasgupta M, Rolfson DB, Stolee P, Borrie MJ, Speechley M. Frailty is associated with postoperative complications in older adults with medical problems. Arch Gerontol Geriatr. 2009;48(1):78–83.PubMed Dasgupta M, Rolfson DB, Stolee P, Borrie MJ, Speechley M. Frailty is associated with postoperative complications in older adults with medical problems. Arch Gerontol Geriatr. 2009;48(1):78–83.PubMed
32.
go back to reference Goeteyn J, Evans LA, De Cleyn S, Fauconnier S, Damen C, Hewitt J, et al. Frailty as a predictor of mortality in the elderly emergency general surgery patient. Acta Chir Belg. 2017;117(6):370–5.PubMed Goeteyn J, Evans LA, De Cleyn S, Fauconnier S, Damen C, Hewitt J, et al. Frailty as a predictor of mortality in the elderly emergency general surgery patient. Acta Chir Belg. 2017;117(6):370–5.PubMed
33.
go back to reference Rodrigues MK, Marques A, Lobo DML, Umeda IIK, Oliveira MF. Pre-frailty increases the risk of adverse events in older patients undergoing cardiovascular surgery. Arq Bras Cardiol. 2017;109(4):299–306.PubMedPubMedCentral Rodrigues MK, Marques A, Lobo DML, Umeda IIK, Oliveira MF. Pre-frailty increases the risk of adverse events in older patients undergoing cardiovascular surgery. Arq Bras Cardiol. 2017;109(4):299–306.PubMedPubMedCentral
34.
go back to reference Reichart D, Rosato S, Nammas W, Onorati F, Dalén M, Castro L, et al. Clinical frailty scale and outcome after coronary artery bypass grafting. Eur J Cardio-Thorac Surg Off J Eur Assoc Cardio-Thorac Surg. 2018;54(6):1102–9. Reichart D, Rosato S, Nammas W, Onorati F, Dalén M, Castro L, et al. Clinical frailty scale and outcome after coronary artery bypass grafting. Eur J Cardio-Thorac Surg Off J Eur Assoc Cardio-Thorac Surg. 2018;54(6):1102–9.
35.
go back to reference Kim S, Marsh AP, Rustowicz L, Roach C, Leng XI, Kritchevsky SB, et al. Self-reported mobility in older patients predicts early postoperative outcomes after elective noncardiac surgery. Anesthesiology. 2016;124(4):815–25.PubMed Kim S, Marsh AP, Rustowicz L, Roach C, Leng XI, Kritchevsky SB, et al. Self-reported mobility in older patients predicts early postoperative outcomes after elective noncardiac surgery. Anesthesiology. 2016;124(4):815–25.PubMed
36.
go back to reference Lytwyn J, Stammers AN, Kehler DS, Jung P, Alexander B, Hiebert BM, et al. The impact of frailty on functional survival in patients 1 year after cardiac surgery. J Thorac Cardiovasc Surg. 2017;154(6):1990–9.PubMed Lytwyn J, Stammers AN, Kehler DS, Jung P, Alexander B, Hiebert BM, et al. The impact of frailty on functional survival in patients 1 year after cardiac surgery. J Thorac Cardiovasc Surg. 2017;154(6):1990–9.PubMed
37.
go back to reference Kapoor A, Matheos T, Walz M, McDonough C, Maheswaran A, Ruppell E, et al. Self-reported function more informative than frailty phenotype in predicting adverse postoperative course in older adults. J Am Geriatr Soc. 2017;65(11):2522–8.PubMedPubMedCentral Kapoor A, Matheos T, Walz M, McDonough C, Maheswaran A, Ruppell E, et al. Self-reported function more informative than frailty phenotype in predicting adverse postoperative course in older adults. J Am Geriatr Soc. 2017;65(11):2522–8.PubMedPubMedCentral
38.
go back to reference Clegg A, Bates C, Young J, Ryan R, Nichols L, Ann Teale E, et al. Development and validation of an electronic frailty index using routine primary care electronic health record data. Age Ageing. 2016;45(3):353–60.PubMedPubMedCentral Clegg A, Bates C, Young J, Ryan R, Nichols L, Ann Teale E, et al. Development and validation of an electronic frailty index using routine primary care electronic health record data. Age Ageing. 2016;45(3):353–60.PubMedPubMedCentral
40.
go back to reference • Hall DE, Arya S, Schmid KK, Carlson MA, Lavedan P, Bailey TL, et al. Association of a frailty screening initiative with postoperative survival at 30, 180, and 365 days. JAMA Surg. 2017;152(3):233–40 Identification of patients living with frailty before surgery was associated with improved outcomes in this prospective cohort study. PubMedPubMedCentral • Hall DE, Arya S, Schmid KK, Carlson MA, Lavedan P, Bailey TL, et al. Association of a frailty screening initiative with postoperative survival at 30, 180, and 365 days. JAMA Surg. 2017;152(3):233–40 Identification of patients living with frailty before surgery was associated with improved outcomes in this prospective cohort study. PubMedPubMedCentral
41.
go back to reference Partridge JSL, Harari D, Martin FC, Dhesi JK. The impact of pre-operative comprehensive geriatric assessment on postoperative outcomes in older patients undergoing scheduled surgery: a systematic review. Anaesthesia. 2014;69(Suppl 1):8–16.PubMed Partridge JSL, Harari D, Martin FC, Dhesi JK. The impact of pre-operative comprehensive geriatric assessment on postoperative outcomes in older patients undergoing scheduled surgery: a systematic review. Anaesthesia. 2014;69(Suppl 1):8–16.PubMed
42.
go back to reference McIsaac DI, Wong CA, Bryson GL, van Walraven C. Association of polypharmacy with survival, complications, and healthcare resource use after elective noncardiac surgery: a population-based cohort study. Anesthesiology. 2018;128(6):1140–50.PubMed McIsaac DI, Wong CA, Bryson GL, van Walraven C. Association of polypharmacy with survival, complications, and healthcare resource use after elective noncardiac surgery: a population-based cohort study. Anesthesiology. 2018;128(6):1140–50.PubMed
43.
go back to reference Herr M, Robine J-M, Pinot J, Arvieu J-J, Ankri J. Polypharmacy and frailty: prevalence, relationship, and impact on mortality in a French sample of 2350 old people. Pharmacoepidemiol Drug Saf. 2015;24(6):637–46.PubMed Herr M, Robine J-M, Pinot J, Arvieu J-J, Ankri J. Polypharmacy and frailty: prevalence, relationship, and impact on mortality in a French sample of 2350 old people. Pharmacoepidemiol Drug Saf. 2015;24(6):637–46.PubMed
44.
go back to reference Ng TP, Feng L, Nyunt MSZ, Feng L, Niti M, Tan BY, et al. Nutritional, physical, cognitive, and combination interventions and frailty reversal among older adults: a randomized controlled trial. Am J Med. 2015;128(11):1225–1236.e1.PubMed Ng TP, Feng L, Nyunt MSZ, Feng L, Niti M, Tan BY, et al. Nutritional, physical, cognitive, and combination interventions and frailty reversal among older adults: a randomized controlled trial. Am J Med. 2015;128(11):1225–1236.e1.PubMed
45.
go back to reference Milder DA, Pillinger NL, Kam PCA. The role of prehabilitation in frail surgical patients: a systematic review. Acta Anaesthesiol Scand. 2018;62(10):1356–66.PubMed Milder DA, Pillinger NL, Kam PCA. The role of prehabilitation in frail surgical patients: a systematic review. Acta Anaesthesiol Scand. 2018;62(10):1356–66.PubMed
46.
go back to reference • Partridge JSL, Harari D, Martin FC, Peacock JL, Bell R, Mohammed A, et al. Randomized clinical trial of comprehensive geriatric assessment and optimization in vascular surgery. Br J Surg. 2017;104(6):679–87 Preoperative geriatric consult decreased length of stay in older patients undergoing vascular surgery. PubMed • Partridge JSL, Harari D, Martin FC, Peacock JL, Bell R, Mohammed A, et al. Randomized clinical trial of comprehensive geriatric assessment and optimization in vascular surgery. Br J Surg. 2017;104(6):679–87 Preoperative geriatric consult decreased length of stay in older patients undergoing vascular surgery. PubMed
47.
go back to reference McIsaac DI, Huang A, Wong CA, Wijeysundera DN, Bryson GL, van Walraven C. Effect of preoperative geriatric evaluation on outcomes after elective surgery: a population-based study. J Am Geriatr Soc. 2017;65(12):2665–72.PubMed McIsaac DI, Huang A, Wong CA, Wijeysundera DN, Bryson GL, van Walraven C. Effect of preoperative geriatric evaluation on outcomes after elective surgery: a population-based study. J Am Geriatr Soc. 2017;65(12):2665–72.PubMed
48.
go back to reference •• Barberan-Garcia A, Ubré M, Roca J, Lacy AM, Burgos F, Risco R, et al. Personalised prehabilitation in high-risk patients undergoing elective major abdominal surgery: a randomized blinded controlled trial. Ann Surg. 2018;267(1):50–6 Prehabilitation (motivational interview, endurance training, and promotion of physical activity) halved the incidence of postoperative complications in a randomized trial of 144 total patients. PubMed •• Barberan-Garcia A, Ubré M, Roca J, Lacy AM, Burgos F, Risco R, et al. Personalised prehabilitation in high-risk patients undergoing elective major abdominal surgery: a randomized blinded controlled trial. Ann Surg. 2018;267(1):50–6 Prehabilitation (motivational interview, endurance training, and promotion of physical activity) halved the incidence of postoperative complications in a randomized trial of 144 total patients. PubMed
49.
go back to reference Minnella EM, Awasthi R, Gillis C, Fiore JF, Liberman AS, Charlebois P, et al. Patients with poor baseline walking capacity are most likely to improve their functional status with multimodal prehabilitation. Surgery. 2016;160(4):1070–9.PubMed Minnella EM, Awasthi R, Gillis C, Fiore JF, Liberman AS, Charlebois P, et al. Patients with poor baseline walking capacity are most likely to improve their functional status with multimodal prehabilitation. Surgery. 2016;160(4):1070–9.PubMed
50.
go back to reference • Hughes MJ, Hackney RJ, Lamb PJ, Wigmore SJ, Christopher Deans DA, Skipworth RJE. Prehabilitation before major abdominal surgery: a systematic review and mseta-analysis. World J Surg. 2019;43(7):1661–8 The literature in prehabilitation points to decreased morbidity, though the optimal protocol remains to be researched. PubMed • Hughes MJ, Hackney RJ, Lamb PJ, Wigmore SJ, Christopher Deans DA, Skipworth RJE. Prehabilitation before major abdominal surgery: a systematic review and mseta-analysis. World J Surg. 2019;43(7):1661–8 The literature in prehabilitation points to decreased morbidity, though the optimal protocol remains to be researched. PubMed
51.
go back to reference Hofman CS, Makai P, Boter H, Buurman BM, de Craen AJ, Olde Rikkert MG, et al. The influence of age on health valuations: the older olds prefer functional independence while the younger olds prefer less morbidity. Clin Interv Aging. 2015;10:1131–9.PubMedPubMedCentral Hofman CS, Makai P, Boter H, Buurman BM, de Craen AJ, Olde Rikkert MG, et al. The influence of age on health valuations: the older olds prefer functional independence while the younger olds prefer less morbidity. Clin Interv Aging. 2015;10:1131–9.PubMedPubMedCentral
52.
go back to reference Barry MJ, Edgman-Levitan S. Shared decision making—pinnacle of patient-centered care. N Engl J Med. 2012;366(9):780–1.PubMed Barry MJ, Edgman-Levitan S. Shared decision making—pinnacle of patient-centered care. N Engl J Med. 2012;366(9):780–1.PubMed
53.
go back to reference Reid L, Lahey W, Livingstone B, McNally M. Ethical and legal implications of frailty screening. J Frailty Aging. 2018;7(4):224–32.PubMed Reid L, Lahey W, Livingstone B, McNally M. Ethical and legal implications of frailty screening. J Frailty Aging. 2018;7(4):224–32.PubMed
54.
go back to reference Stubenrouch FE, Mus EMK, Lut JW, Hesselink EM, Ubbink DT. The current level of shared decision-making in anesthesiology: an exploratory study. BMC Anesthesiol. 2017;17(1):95.PubMedPubMedCentral Stubenrouch FE, Mus EMK, Lut JW, Hesselink EM, Ubbink DT. The current level of shared decision-making in anesthesiology: an exploratory study. BMC Anesthesiol. 2017;17(1):95.PubMedPubMedCentral
55.
go back to reference van de Pol MHJ, Fluit CRMG, Lagro J, Slaats Y, Olde Rikkert MGM, Lagro-Janssen ALM. Shared decision making with frail older patients: proposed teaching framework and practice recommendations. Gerontol Geriatr Educ. 2017;38(4):482–95.PubMed van de Pol MHJ, Fluit CRMG, Lagro J, Slaats Y, Olde Rikkert MGM, Lagro-Janssen ALM. Shared decision making with frail older patients: proposed teaching framework and practice recommendations. Gerontol Geriatr Educ. 2017;38(4):482–95.PubMed
56.
go back to reference Geessink NH, Schoon Y, van Herk HCP, van Goor H, Olde Rikkert MGM. Key elements of optimal treatment decision-making for surgeons and older patients with colorectal or pancreatic cancer: a qualitative study. Patient Educ Couns. 2017;100(3):473–9.PubMed Geessink NH, Schoon Y, van Herk HCP, van Goor H, Olde Rikkert MGM. Key elements of optimal treatment decision-making for surgeons and older patients with colorectal or pancreatic cancer: a qualitative study. Patient Educ Couns. 2017;100(3):473–9.PubMed
57.
go back to reference Stacey D, Kryworuchko J, Bennett C, Murray MA, Mullan S, Légaré F. Decision coaching to prepare patients for making health decisions: a systematic review of decision coaching in trials of patient decision AIDS. Med Decis Mak Int J Soc Med Decis Mak. 2012;32(3):E22–33. Stacey D, Kryworuchko J, Bennett C, Murray MA, Mullan S, Légaré F. Decision coaching to prepare patients for making health decisions: a systematic review of decision coaching in trials of patient decision AIDS. Med Decis Mak Int J Soc Med Decis Mak. 2012;32(3):E22–33.
58.
go back to reference Eikelboom R, Gagliardi AR, Gandhi R, Kuzyk PRT, Soong C, Cram P. Patient and caregiver understanding of prognosis after hip fracture. Can Geriatr J CGJ. 2018;21(3):274–83.PubMed Eikelboom R, Gagliardi AR, Gandhi R, Kuzyk PRT, Soong C, Cram P. Patient and caregiver understanding of prognosis after hip fracture. Can Geriatr J CGJ. 2018;21(3):274–83.PubMed
59.
go back to reference Paruch JL, Ko CY, Bilimoria KY. An opportunity to improve informed consent and shared decision making: the role of the ACS NSQIP surgical risk calculator in oncology. Ann Surg Oncol. 2014;21(1):5–7.PubMed Paruch JL, Ko CY, Bilimoria KY. An opportunity to improve informed consent and shared decision making: the role of the ACS NSQIP surgical risk calculator in oncology. Ann Surg Oncol. 2014;21(1):5–7.PubMed
60.
go back to reference Birchley G, Jones K, Huxtable R, Dixon J, Kitzinger J, Clare L. Dying well with reduced agency: a scoping review and thematic synthesis of the decision-making process in dementia, traumatic brain injury and frailty. BMC Med Ethics. 2016;17(1):46.PubMedPubMedCentral Birchley G, Jones K, Huxtable R, Dixon J, Kitzinger J, Clare L. Dying well with reduced agency: a scoping review and thematic synthesis of the decision-making process in dementia, traumatic brain injury and frailty. BMC Med Ethics. 2016;17(1):46.PubMedPubMedCentral
61.
go back to reference Steffens NM, Tucholka JL, Nabozny MJ, Schmick AE, Brasel KJ, Schwarze ML. Engaging patients, health care professionals, and community members to improve preoperative decision making for older adults facing high-risk surgery. JAMA Surg. 2016;151(10):938–45.PubMedPubMedCentral Steffens NM, Tucholka JL, Nabozny MJ, Schmick AE, Brasel KJ, Schwarze ML. Engaging patients, health care professionals, and community members to improve preoperative decision making for older adults facing high-risk surgery. JAMA Surg. 2016;151(10):938–45.PubMedPubMedCentral
62.
go back to reference • Avidan MS, Maybrier HR, Abdallah AB, Jacobsohn E, Vlisides PE, Pryor KO, et al. Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial. Lancet Lond Engl. 2017;390(10091):267–75 A small dose of ketamine during anesthesia did not prevent delirium. • Avidan MS, Maybrier HR, Abdallah AB, Jacobsohn E, Vlisides PE, Pryor KO, et al. Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial. Lancet Lond Engl. 2017;390(10091):267–75 A small dose of ketamine during anesthesia did not prevent delirium.
63.
go back to reference • Deiner S, Luo X, Lin H-M, Sessler DI, Saager L, Sieber FE, et al. Intraoperative infusion of dexmedetomidine for prevention of postoperative delirium and cognitive dysfunction in elderly patients undergoing major elective noncardiac surgery: a randomized clinical trial. JAMA Surg. 2017;152(8):e171505 Dexmedetomiedine infusion during anesthesia did not reduce delirium. PubMedPubMedCentral • Deiner S, Luo X, Lin H-M, Sessler DI, Saager L, Sieber FE, et al. Intraoperative infusion of dexmedetomidine for prevention of postoperative delirium and cognitive dysfunction in elderly patients undergoing major elective noncardiac surgery: a randomized clinical trial. JAMA Surg. 2017;152(8):e171505 Dexmedetomiedine infusion during anesthesia did not reduce delirium. PubMedPubMedCentral
64.
go back to reference Sieber F, Neufeld KJ, Gottschalk A, Bigelow GE, Oh ES, Rosenberg PB, et al. Depth of sedation as an interventional target to reduce postoperative delirium: mortality and functional outcomes of the strategy to reduce the incidence of postoperative delirium in elderly patients randomised clinical trial. BJA Br J Anaesth. 2019;122(4):480–9.PubMed Sieber F, Neufeld KJ, Gottschalk A, Bigelow GE, Oh ES, Rosenberg PB, et al. Depth of sedation as an interventional target to reduce postoperative delirium: mortality and functional outcomes of the strategy to reduce the incidence of postoperative delirium in elderly patients randomised clinical trial. BJA Br J Anaesth. 2019;122(4):480–9.PubMed
65.
go back to reference Cheng X-Q, Mei B, Zuo Y-M, Wu H, Peng X-H, Zhao Q, et al. A multicentre randomised controlled trial of the effect of intra-operative dexmedetomidine on cognitive decline after surgery. Anaesthesia. 2019;74(6):741–50.PubMed Cheng X-Q, Mei B, Zuo Y-M, Wu H, Peng X-H, Zhao Q, et al. A multicentre randomised controlled trial of the effect of intra-operative dexmedetomidine on cognitive decline after surgery. Anaesthesia. 2019;74(6):741–50.PubMed
66.
go back to reference Miller D, Lewis SR, Pritchard MW, Schofield-Robinson OJ, Shelton CL, Alderson P, et al. Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery. Cochrane Database Syst Rev. 2018;8:CD012317.PubMed Miller D, Lewis SR, Pritchard MW, Schofield-Robinson OJ, Shelton CL, Alderson P, et al. Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery. Cochrane Database Syst Rev. 2018;8:CD012317.PubMed
68.
go back to reference James LA, Levin MA, Lin H-M, Deiner SG. Association of preoperative frailty with intraoperative hemodynamic instability and postoperative mortality. Anesth Analg. 2019;128(6):1279–85.PubMed James LA, Levin MA, Lin H-M, Deiner SG. Association of preoperative frailty with intraoperative hemodynamic instability and postoperative mortality. Anesth Analg. 2019;128(6):1279–85.PubMed
69.
go back to reference Futier E, Lefrant J-Y, Guinot P-G, Godet T, Lorne E, Cuvillon P, et al. Effect of individualized vs standard blood pressure management strategies on postoperative organ dysfunction among high-risk patients undergoing major surgery: a randomized clinical trial. JAMA. 2017;318(14):1346–57.PubMedPubMedCentral Futier E, Lefrant J-Y, Guinot P-G, Godet T, Lorne E, Cuvillon P, et al. Effect of individualized vs standard blood pressure management strategies on postoperative organ dysfunction among high-risk patients undergoing major surgery: a randomized clinical trial. JAMA. 2017;318(14):1346–57.PubMedPubMedCentral
70.
go back to reference Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, et al. Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review. JAMA. 2014;311(21):2181–90.PubMed Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, et al. Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review. JAMA. 2014;311(21):2181–90.PubMed
71.
go back to reference Nordquist D, Halaszynski TM. Perioperative multimodal anesthesia using regional techniques in the aging surgical patient. Pain Res Treat. 2014;2014:902174.PubMedPubMedCentral Nordquist D, Halaszynski TM. Perioperative multimodal anesthesia using regional techniques in the aging surgical patient. Pain Res Treat. 2014;2014:902174.PubMedPubMedCentral
73.
go back to reference Fournier J-P, Azoulay L, Yin H, Montastruc J-L, Suissa S. Tramadol use and the risk of hospitalization for hypoglycemia in patients with noncancer pain. JAMA Intern Med. 2015;175(2):186–93.PubMed Fournier J-P, Azoulay L, Yin H, Montastruc J-L, Suissa S. Tramadol use and the risk of hospitalization for hypoglycemia in patients with noncancer pain. JAMA Intern Med. 2015;175(2):186–93.PubMed
74.
go back to reference Mathieson S, Maher CG, McLachlan AJ, Latimer J, Koes BW, Hancock MJ, et al. Trial of pregabalin for acute and chronic sciatica. N Engl J Med. 2017;376(12):1111–20.PubMed Mathieson S, Maher CG, McLachlan AJ, Latimer J, Koes BW, Hancock MJ, et al. Trial of pregabalin for acute and chronic sciatica. N Engl J Med. 2017;376(12):1111–20.PubMed
75.
go back to reference Gomes T, Juurlink DN, Antoniou T, Mamdani MM, Paterson JM, van den Brink W. Gabapentin, opioids, and the risk of opioid-related death: a population-based nested case-control study. PLoS Med. 2017;14(10):e1002396.PubMedPubMedCentral Gomes T, Juurlink DN, Antoniou T, Mamdani MM, Paterson JM, van den Brink W. Gabapentin, opioids, and the risk of opioid-related death: a population-based nested case-control study. PLoS Med. 2017;14(10):e1002396.PubMedPubMedCentral
76.
go back to reference Gomes T, Greaves S, van den Brink W, Antoniou T, Mamdani MM, Paterson JM, et al. Pregabalin and the risk for opioid-related death: a nested case-control study. Ann Intern Med. 2018;169(10):732–4.PubMed Gomes T, Greaves S, van den Brink W, Antoniou T, Mamdani MM, Paterson JM, et al. Pregabalin and the risk for opioid-related death: a nested case-control study. Ann Intern Med. 2018;169(10):732–4.PubMed
77.
go back to reference Ladha KS, Patorno E, Huybrechts KF, Liu J, Rathmell JP, Bateman BT. Variations in the Use of perioperative multimodal analgesic therapy. Anesthesiology. 2016;124(4):837–45.PubMed Ladha KS, Patorno E, Huybrechts KF, Liu J, Rathmell JP, Bateman BT. Variations in the Use of perioperative multimodal analgesic therapy. Anesthesiology. 2016;124(4):837–45.PubMed
78.
go back to reference Gutiérrez-Valencia M, Izquierdo M, Cesari M, Casas-Herrero Á, Inzitari M, Martínez-Velilla N. The relationship between frailty and polypharmacy in older people: a systematic review. Br J Clin Pharmacol. 2018;84(7):1432–44.PubMedPubMedCentral Gutiérrez-Valencia M, Izquierdo M, Cesari M, Casas-Herrero Á, Inzitari M, Martínez-Velilla N. The relationship between frailty and polypharmacy in older people: a systematic review. Br J Clin Pharmacol. 2018;84(7):1432–44.PubMedPubMedCentral
79.
go back to reference Lin C, Darling C, Tsui BCH. Practical regional anesthesia guide for elderly patients. Drugs Aging. 2019;36(3):213–34.PubMed Lin C, Darling C, Tsui BCH. Practical regional anesthesia guide for elderly patients. Drugs Aging. 2019;36(3):213–34.PubMed
80.
go back to reference •• Guay J, Parker MJ, Griffiths R, Kopp S. Peripheral nerve blocks for hip fractures. Cochrane Database Syst Rev. 2017;5:CD001159 Updated review on the evidence behind regional anesthesia for hip fracture patients.PubMed •• Guay J, Parker MJ, Griffiths R, Kopp S. Peripheral nerve blocks for hip fractures. Cochrane Database Syst Rev. 2017;5:CD001159 Updated review on the evidence behind regional anesthesia for hip fracture patients.PubMed
81.
go back to reference •• McIsaac DI, Bryson GL, van Walraven C. Association of frailty and 1-year postoperative mortality following major elective noncardiac surgery: a population-based cohort study. JAMA Surg. 2016;151(6):538–45 Population cohort of surgical patients revealed strong association between frailty and mortality.PubMed •• McIsaac DI, Bryson GL, van Walraven C. Association of frailty and 1-year postoperative mortality following major elective noncardiac surgery: a population-based cohort study. JAMA Surg. 2016;151(6):538–45 Population cohort of surgical patients revealed strong association between frailty and mortality.PubMed
82.
go back to reference Shah R, Attwood K, Arya S, Hall DE, Johanning JM, Gabriel E, et al. Association of frailty with failure to rescue after low-risk and high-risk inpatient surgery. JAMA Surg. 2018;153(5):e180214.PubMedPubMedCentral Shah R, Attwood K, Arya S, Hall DE, Johanning JM, Gabriel E, et al. Association of frailty with failure to rescue after low-risk and high-risk inpatient surgery. JAMA Surg. 2018;153(5):e180214.PubMedPubMedCentral
83.
go back to reference Granich R, Sutton Z, Kim YS, Anderson M, Wood H, Scharf JE, et al. Early detection of critical illness outside the intensive care unit: clarifying treatment plans and honoring goals of care using a supportive care team. J Hosp Med. 2016;11(Suppl 1):S40–7.PubMed Granich R, Sutton Z, Kim YS, Anderson M, Wood H, Scharf JE, et al. Early detection of critical illness outside the intensive care unit: clarifying treatment plans and honoring goals of care using a supportive care team. J Hosp Med. 2016;11(Suppl 1):S40–7.PubMed
84.
go back to reference McIsaac DI, Wijeysundera DN, Huang A, Bryson GL, van Walraven C. Association of the hospital volume of frail surgical patients cared for with outcomes after elective, major noncardiac surgery: a retrospective population-based cohort study. Anesthesiology. 2017;126(4):602–13.PubMed McIsaac DI, Wijeysundera DN, Huang A, Bryson GL, van Walraven C. Association of the hospital volume of frail surgical patients cared for with outcomes after elective, major noncardiac surgery: a retrospective population-based cohort study. Anesthesiology. 2017;126(4):602–13.PubMed
85.
go back to reference Ghaferi AA, Birkmeyer JD, Dimick JB. Variation in hospital mortality associated with inpatient surgery. N Engl J Med. 2009;361(14):1368–75.PubMed Ghaferi AA, Birkmeyer JD, Dimick JB. Variation in hospital mortality associated with inpatient surgery. N Engl J Med. 2009;361(14):1368–75.PubMed
86.
go back to reference Harari D, Hopper A, Dhesi J, Babic-Illman G, Lockwood L, Martin F. Proactive care of older people undergoing surgery (‘POPS’): designing, embedding, evaluating and funding a comprehensive geriatric assessment service for older elective surgical patients. Age Ageing. 2007;36(2):190–6.PubMed Harari D, Hopper A, Dhesi J, Babic-Illman G, Lockwood L, Martin F. Proactive care of older people undergoing surgery (‘POPS’): designing, embedding, evaluating and funding a comprehensive geriatric assessment service for older elective surgical patients. Age Ageing. 2007;36(2):190–6.PubMed
87.
go back to reference Mallery L, Moor-house P. Palliative and therapeutic harmonization. Healthc Manage Forum. 2014;27(1):37–40.PubMed Mallery L, Moor-house P. Palliative and therapeutic harmonization. Healthc Manage Forum. 2014;27(1):37–40.PubMed
88.
go back to reference McDonald SR, Heflin MT, Whitson HE, Dalton TO, Lidsky ME, Liu P, et al. Association of integrated care coordination with postsurgical outcomes in high-risk older adults: the Perioperative Optimization of Senior Health (POSH) initiative. JAMA Surg. 2018;153(5):454–62.PubMedPubMedCentral McDonald SR, Heflin MT, Whitson HE, Dalton TO, Lidsky ME, Liu P, et al. Association of integrated care coordination with postsurgical outcomes in high-risk older adults: the Perioperative Optimization of Senior Health (POSH) initiative. JAMA Surg. 2018;153(5):454–62.PubMedPubMedCentral
89.
go back to reference Prestmo A, Hagen G, Sletvold O, Helbostad JL, Thingstad P, Taraldsen K, et al. Comprehensive geriatric care for patients with hip fractures: a prospective, randomised, controlled trial. Lancet Lond Engl. 2015;385(9978):1623–33. Prestmo A, Hagen G, Sletvold O, Helbostad JL, Thingstad P, Taraldsen K, et al. Comprehensive geriatric care for patients with hip fractures: a prospective, randomised, controlled trial. Lancet Lond Engl. 2015;385(9978):1623–33.
90.
go back to reference Chan SP, Ip KY, Irwin MG. Peri-operative optimisation of elderly and frail patients: a narrative review. Anaesthesia. 2019;74(Suppl 1):80–9.PubMed Chan SP, Ip KY, Irwin MG. Peri-operative optimisation of elderly and frail patients: a narrative review. Anaesthesia. 2019;74(Suppl 1):80–9.PubMed
91.
go back to reference •• Puts MTE, Toubasi S, Andrew MK, Ashe MC, Ploeg J, Atkinson E, et al. Interventions to prevent or reduce the level of frailty in community-dwelling older adults: a scoping review of the literature and international policies. Age Ageing. 2017;46(3):383–92 Review of evidence for interventions for patients with frailty in the community setting.PubMedPubMedCentral •• Puts MTE, Toubasi S, Andrew MK, Ashe MC, Ploeg J, Atkinson E, et al. Interventions to prevent or reduce the level of frailty in community-dwelling older adults: a scoping review of the literature and international policies. Age Ageing. 2017;46(3):383–92 Review of evidence for interventions for patients with frailty in the community setting.PubMedPubMedCentral
92.
go back to reference •• McIsaac DI, Jen T, Mookerji N, Patel A, Lalu MM. Interventions to improve the outcomes of frail people having surgery: a systematic review. PLoS One. 2017;12(12):e0190071 Systematic review of perioperative strategies for patients with frailty. PubMedPubMedCentral •• McIsaac DI, Jen T, Mookerji N, Patel A, Lalu MM. Interventions to improve the outcomes of frail people having surgery: a systematic review. PLoS One. 2017;12(12):e0190071 Systematic review of perioperative strategies for patients with frailty. PubMedPubMedCentral
93.
go back to reference Fried TR, Bradley EH, Towle VR, Allore H. Understanding the treatment preferences of seriously ill patients. N Engl J Med. 2002;346(14):1061–6.PubMed Fried TR, Bradley EH, Towle VR, Allore H. Understanding the treatment preferences of seriously ill patients. N Engl J Med. 2002;346(14):1061–6.PubMed
94.
go back to reference Akpan A, Roberts C, Bandeen-Roche K, Batty B, Bausewein C, Bell D, et al. Standard set of health outcome measures for older persons. BMC Geriatr. 2018;18(1):36.PubMedPubMedCentral Akpan A, Roberts C, Bandeen-Roche K, Batty B, Bausewein C, Bell D, et al. Standard set of health outcome measures for older persons. BMC Geriatr. 2018;18(1):36.PubMedPubMedCentral
95.
go back to reference Myles PS, Grocott MPW, Boney O, Moonesinghe SR, Myles P, Grocott M, et al. Standardizing end points in perioperative trials: towards a core and extended outcome set. BJA Br J Anaesth. 2016;116(5):586–9.PubMed Myles PS, Grocott MPW, Boney O, Moonesinghe SR, Myles P, Grocott M, et al. Standardizing end points in perioperative trials: towards a core and extended outcome set. BJA Br J Anaesth. 2016;116(5):586–9.PubMed
96.
go back to reference McIsaac DI, Saunders C, Hladkowicz E, Bryson GL, Forster AJ, Gagne S, et al. PREHAB study: a protocol for a prospective randomised clinical trial of exercise therapy for people living with frailty having cancer surgery. BMJ Open. 2018;8(6):e022057.PubMedPubMedCentral McIsaac DI, Saunders C, Hladkowicz E, Bryson GL, Forster AJ, Gagne S, et al. PREHAB study: a protocol for a prospective randomised clinical trial of exercise therapy for people living with frailty having cancer surgery. BMJ Open. 2018;8(6):e022057.PubMedPubMedCentral
98.
go back to reference Looman WM, Fabbricotti IN, Blom JW, Jansen APD, Lutomski JE, Metzelthin SF, et al. The frail older person does not exist: development of frailty profiles with latent class analysis. BMC Geriatr. 2018;18(1):84.PubMedPubMedCentral Looman WM, Fabbricotti IN, Blom JW, Jansen APD, Lutomski JE, Metzelthin SF, et al. The frail older person does not exist: development of frailty profiles with latent class analysis. BMC Geriatr. 2018;18(1):84.PubMedPubMedCentral
101.
go back to reference Mekli K, Marshall A, Vanhoutte B, Tampubolon G, Nazroo J, Pendleton N. The genetics of frailty: summary of the results of the genetics work in the FRAILL project. Innov Aging. 2017;1(suppl_1):137.PubMedCentral Mekli K, Marshall A, Vanhoutte B, Tampubolon G, Nazroo J, Pendleton N. The genetics of frailty: summary of the results of the genetics work in the FRAILL project. Innov Aging. 2017;1(suppl_1):137.PubMedCentral
102.
go back to reference Kojima G, Liljas AEM, Iliffe S. Frailty syndrome: implications and challenges for health care policy. Risk Manag Healthc Policy. 2019;12:23–30.PubMedPubMedCentral Kojima G, Liljas AEM, Iliffe S. Frailty syndrome: implications and challenges for health care policy. Risk Manag Healthc Policy. 2019;12:23–30.PubMedPubMedCentral
Metadata
Title
Perioperative Acute Care of Older Patients Living with Frailty
Authors
Janny Xue Chen Ke
David B. MacDonald
Daniel I. McIsaac
Publication date
01-12-2019
Publisher
Springer US
Keyword
Care
Published in
Current Anesthesiology Reports / Issue 4/2019
Electronic ISSN: 2167-6275
DOI
https://doi.org/10.1007/s40140-019-00355-8

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