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Open Access 01-08-2021 | Care | Original Communication

Contribution of neuropsychiatric symptoms in Parkinson’s disease to different domains of caregiver burden

Authors: L. M. Chahine, R. Feldman, A. Althouse, B. Torsney, L. Alzyoud, S. Mantri, B. Edison, S. Albert, M. Daeschler, C. Kopil, C. Marras

Published in: Journal of Neurology | Issue 8/2021

Abstract

Introduction

Caregiver burden is high among caregivers of PD patients (CPD). Neuropsychiatric symptoms are leading contributors to CPD burden, but whether different symptoms differentially impact domains of caregiver burden is not known. Our objective was to examine which neuropsychiatric symptoms and demographic factors contribute to different domains of caregiver burden in PD.

Methods

This was a cross-sectional online survey study. Participants were recruited from the Fox Insight (FI) study and were eligible if they identified themselves as a CPD. The primary outcome was the Caregiver Burden Inventory (CBI) total score and its 5 sub-domain scores. The Neuropsychiatric Inventory Questionnaire (NPI-Q) assessed caregiver-reported neuropsychiatric symptoms in the care recipient. Multivariable linear regression models were used to characterize the associations between NPI-Q symptom severity scores and CBI scores. Covariates were caregiver age, sex, education, and caregiving duration.

Results

The sample consisted of 450 CPD, mean age 65.87 (SD 10.39) years, 74% females. After adjusting for covariates, CBI total score was predicted by NPI-Q total score (β = 1.96, p < 0.001); model adjusted R² = 39.2%. Anxiety severity had the largest effect size [standardized β (sβ) = 0.224] on the time-dependency domain, which was also associated with female sex (sβ = − 0.133) and age (sβ = 0.088). Severity of disinhibition (sβ = 0.218), agitation (sβ = 0.199), and female sex (sβ = 0.104) were associated with greater emotional burden.

Conclusion

Our findings indicate that demographic characteristics and specific neuropsychiatric symptoms contribute differentially to domains of caregiver burden. Tailored interventions to support CPD are needed.

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Title: Contribution of neuropsychiatric symptoms in Parkinson’s disease to different domains of caregiver burden
Authors: L. M. Chahine
R. Feldman
A. Althouse
B. Torsney
L. Alzyoud
S. Mantri
B. Edison
S. Albert
M. Daeschler
C. Kopil
C. Marras
Publication date: 01-08-2021
Publisher: Springer Berlin Heidelberg
Keywords: Care
Parkinson's Disease
Agitation
Anxiety
Published in: Journal of Neurology / Issue 8/2021
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-021-10443-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Contribution of neuropsychiatric symptoms in Parkinson’s disease to different domains of caregiver burden

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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