Skip to main content
Top
Published in: BMC Complementary Medicine and Therapies 1/2020

01-12-2020 | Care | Research article

Effectiveness of herbal oral care products in reducing dental plaque & gingivitis – a systematic review and meta-analysis

Authors: Chandrashekar Janakiram, Ramanarayanan Venkitachalam, Paul Fontelo, Timothy J. Iafolla, Bruce A. Dye

Published in: BMC Complementary Medicine and Therapies | Issue 1/2020

Login to get access

Abstract

Background

Despite the large number of trials conducted using herbal oral care products for the reduction of dental plaque or gingivitis, results are conflicting and inconclusive.

Objective

To assess the effectiveness of herbal oral care products compared to conventional products in reducing dental plaque and gingivitis adults.

Methods

We searched the following databases for Randomised controlled trials (RCTs): MEDLINE Ovid, EMBASE Ovid etc. which yielded 493 trails. Of which 24 RCTs comparing herbal toothpaste or mouth rinse with over the counter toothpaste or mouth rinse in adults aged 18 to 65 years were included. Two authors extracted information and assessed the methodological quality of the included studies using Risk of Bias. Meta-analyses using the random-effects model were conducted for four outcomes for tooth paste and mouth rinse respectively. Mean difference (MD) or standardized mean difference (SMD) were used to estimate the effect, with 95% confidence intervals.

Results

A total of 1597 adults participated in 24 RCT studies. These were classified as herbal toothpaste (HTP) (15 trials, 899 participants) and herbal mouth rinse (HMR) (9 trials, 698 participants) compared with non-herbal toothpaste (NHTP) or non-herbal mouth rinse (NHMR). We found that HTP was superior over NHTP (SMD 1.95, 95% CI (0.97–2.93)) in plaque reduction. The long-term use of NHMR was superior in reduction of dental plaque over HMR (SMD -2.61, 95% (CI 4.42–0.80)). From subgroup analysis it showed that HTP was not superior over fluoride toothpaste (SMD 0.99, 95% CI (0.14–2.13)) in reducing dental plaque. However, HTP was favoured over non-fluoride toothpaste (SMD 4.64, 95% CI (2.23–7.05)).

Conclusion

For short-term reduction in dental plaque, current evidence suggests that HTP is as effective as compared to NHTP; however, evidence is from low quality studies.
Appendix
Available only for authorised users
Literature
1.
go back to reference Niklaus Lang, Rolf Attstrom, Loe Harald. Proceedings of the European Workshop on Mechanical Plaque Control. United States of America: Quintessence Publishing (IL); 1998. Niklaus Lang, Rolf Attstrom, Loe Harald. Proceedings of the European Workshop on Mechanical Plaque Control. United States of America: Quintessence Publishing (IL); 1998.
2.
go back to reference van der Weijden GA, Hioe KPK. A systematic review of the effectiveness of self-performed mechanical plaque removal in adults with gingivitis using a manual toothbrush. J Clin Periodontol. 2005;32(Suppl 6):214–28.PubMedCrossRef van der Weijden GA, Hioe KPK. A systematic review of the effectiveness of self-performed mechanical plaque removal in adults with gingivitis using a manual toothbrush. J Clin Periodontol. 2005;32(Suppl 6):214–28.PubMedCrossRef
3.
go back to reference Barnett ML. The rationale for the daily use of an antimicrobial mouthrinse. J Am Dent Assoc 1939. 2006 Nov;137 Suppl:16S–21S.CrossRef Barnett ML. The rationale for the daily use of an antimicrobial mouthrinse. J Am Dent Assoc 1939. 2006 Nov;137 Suppl:16S–21S.CrossRef
4.
go back to reference Serrano J, Escribano M, Roldán S, Martín C, Herrera D. Efficacy of adjunctive anti-plaque chemical agents in managing gingivitis: a systematic review and meta-analysis. J Clin Periodontol. 2015 Apr 1;42:S106–38.PubMedCrossRef Serrano J, Escribano M, Roldán S, Martín C, Herrera D. Efficacy of adjunctive anti-plaque chemical agents in managing gingivitis: a systematic review and meta-analysis. J Clin Periodontol. 2015 Apr 1;42:S106–38.PubMedCrossRef
5.
6.
go back to reference Teles RP, Teles FRF. Antimicrobial agents used in the control of periodontal biofilms: effective adjuncts to mechanical plaque control? Braz Oral Res. 2009;23(Suppl 1):39–48.PubMedCrossRef Teles RP, Teles FRF. Antimicrobial agents used in the control of periodontal biofilms: effective adjuncts to mechanical plaque control? Braz Oral Res. 2009;23(Suppl 1):39–48.PubMedCrossRef
7.
go back to reference Al-Kholani AI. Comparison between the efficacy of herbal and conventional dentifrices on established gingivitis. Dent Res J. 2011;8(2):57–63. Al-Kholani AI. Comparison between the efficacy of herbal and conventional dentifrices on established gingivitis. Dent Res J. 2011;8(2):57–63.
8.
go back to reference Hosamane M, Acharya AB, Vij C, Trivedi D, Setty SB, Thakur SL. Evaluation of holy basil mouthwash as an adjunctive plaque control agent in a four day plaque regrowth model. J Clin Exp Dent. 2014 Dec;6(5):e491–6.PubMedPubMedCentralCrossRef Hosamane M, Acharya AB, Vij C, Trivedi D, Setty SB, Thakur SL. Evaluation of holy basil mouthwash as an adjunctive plaque control agent in a four day plaque regrowth model. J Clin Exp Dent. 2014 Dec;6(5):e491–6.PubMedPubMedCentralCrossRef
9.
go back to reference Abhishek KN, Supreetha S, Sam G, Khan SN, Chaithanya KH, Abdul N. Effect of Neem containing Toothpaste on Plaque and Gingivitis--A Randomized Double Blind Clinical Trial. J Contemp Dent Pract. 2015 01;16(11):880–883. Abhishek KN, Supreetha S, Sam G, Khan SN, Chaithanya KH, Abdul N. Effect of Neem containing Toothpaste on Plaque and Gingivitis--A Randomized Double Blind Clinical Trial. J Contemp Dent Pract. 2015 01;16(11):880–883.
10.
go back to reference Kumar VS, Navaratnam V. Neem (Azadirachta indica): prehistory to contemporary medicinal uses to humankind. Asian Pac J Trop Biomed. 2013;3(7):505–14.PubMedPubMedCentralCrossRef Kumar VS, Navaratnam V. Neem (Azadirachta indica): prehistory to contemporary medicinal uses to humankind. Asian Pac J Trop Biomed. 2013;3(7):505–14.PubMedPubMedCentralCrossRef
13.
go back to reference Chen Y, Wong RWK, McGrath C, Hagg U, Seneviratne CJ. Natural compounds containing mouthrinses in the management of dental plaque and gingivitis: a systematic review. Clin Oral Investig. 2014;18(1):1–16.PubMedCrossRef Chen Y, Wong RWK, McGrath C, Hagg U, Seneviratne CJ. Natural compounds containing mouthrinses in the management of dental plaque and gingivitis: a systematic review. Clin Oral Investig. 2014;18(1):1–16.PubMedCrossRef
14.
go back to reference Dhingra K. Aloe vera herbal dentifrices for plaque and gingivitis control: a systematic review. Oral Dis. 2014 Apr;20(3):254–67.PubMedCrossRef Dhingra K. Aloe vera herbal dentifrices for plaque and gingivitis control: a systematic review. Oral Dis. 2014 Apr;20(3):254–67.PubMedCrossRef
15.
go back to reference Chandra Shekar BR, Nagarajappa R, Suma S, Thakur R. Herbal extracts in oral health care - a review of the current scenario and its future needs. Pharmacogn Rev. 2015;9(18):87–92.PubMedPubMedCentralCrossRef Chandra Shekar BR, Nagarajappa R, Suma S, Thakur R. Herbal extracts in oral health care - a review of the current scenario and its future needs. Pharmacogn Rev. 2015;9(18):87–92.PubMedPubMedCentralCrossRef
16.
go back to reference Freires IA, Rosalen PL. How natural product research has contributed to Oral care product development? A Critical View Pharm Res. 2016;33(6):1311–7.PubMed Freires IA, Rosalen PL. How natural product research has contributed to Oral care product development? A Critical View Pharm Res. 2016;33(6):1311–7.PubMed
18.
go back to reference Higgins JPT, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011 Oct 18;343:d5928.PubMedPubMedCentralCrossRef Higgins JPT, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011 Oct 18;343:d5928.PubMedPubMedCentralCrossRef
20.
go back to reference Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002 Jun 15;21(11):1539–58.PubMedCrossRef Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002 Jun 15;21(11):1539–58.PubMedCrossRef
21.
go back to reference Grading quality of evidence and strength of recommendations. BMJ. 2004 Jun 19;328(7454):1490. Grading quality of evidence and strength of recommendations. BMJ. 2004 Jun 19;328(7454):1490.
22.
go back to reference Ozaki F, Pannuti CM, Imbronito AV, Pessotti W, Saraiva L, de Freitas NM, et al. Efficacy of a herbal toothpaste on patients with established gingivitis--a randomized controlled trial. Braz Oral Res. 2006 Jun;20(2):172–7.PubMedCrossRef Ozaki F, Pannuti CM, Imbronito AV, Pessotti W, Saraiva L, de Freitas NM, et al. Efficacy of a herbal toothpaste on patients with established gingivitis--a randomized controlled trial. Braz Oral Res. 2006 Jun;20(2):172–7.PubMedCrossRef
23.
go back to reference de Oliveira SMA, Torres TC, Pereira SL d S, Mota OM de L, Carlos MX. Effect of a dentifrice containing Aloe vera on plaque and gingivitis control. A double-blind clinical study in humans. J Appl Oral Sci Rev FOB. 2008 Aug;16(4):293–6.CrossRef de Oliveira SMA, Torres TC, Pereira SL d S, Mota OM de L, Carlos MX. Effect of a dentifrice containing Aloe vera on plaque and gingivitis control. A double-blind clinical study in humans. J Appl Oral Sci Rev FOB. 2008 Aug;16(4):293–6.CrossRef
24.
go back to reference Rao S, Avinash S, Rao R, Prahlad S, Mitra SK. A randomized single blind clinical trial to evaluate the safety and efficacy of Himalaya herbal dental cream. Antiseptic. 2008;105(12):601–2. Rao S, Avinash S, Rao R, Prahlad S, Mitra SK. A randomized single blind clinical trial to evaluate the safety and efficacy of Himalaya herbal dental cream. Antiseptic. 2008;105(12):601–2.
25.
go back to reference George J, Hegde S, Rajesh KS, Kumar A. The efficacy of a herbal-based toothpaste in the control of plaque and gingivitis: a clinico-biochemical study. Ind J Dent Res Off Publ Indian Soc Dent Res. 2009 Dec;20(4):480–2.CrossRef George J, Hegde S, Rajesh KS, Kumar A. The efficacy of a herbal-based toothpaste in the control of plaque and gingivitis: a clinico-biochemical study. Ind J Dent Res Off Publ Indian Soc Dent Res. 2009 Dec;20(4):480–2.CrossRef
26.
go back to reference Amoain B, Mogadhamnia AA, Mazandharani M, Amoain MM, Mehrmanesh S. The effect of Calendula extract toothpaste on the plaque index and bleeding in gingivitis. Res J Med Plant. 2010;4(3):132–40.CrossRef Amoain B, Mogadhamnia AA, Mazandharani M, Amoain MM, Mehrmanesh S. The effect of Calendula extract toothpaste on the plaque index and bleeding in gingivitis. Res J Med Plant. 2010;4(3):132–40.CrossRef
27.
go back to reference Amrutesh S, Malini J, Tandur PS, Patki PS. Clinical evaluation of a novel herbal dental cream in plaque formation: a double-blind, randomized, controlled clinical trial. J Exp Pharmacol. 2010;2:105–9.PubMedPubMedCentral Amrutesh S, Malini J, Tandur PS, Patki PS. Clinical evaluation of a novel herbal dental cream in plaque formation: a double-blind, randomized, controlled clinical trial. J Exp Pharmacol. 2010;2:105–9.PubMedPubMedCentral
28.
go back to reference Mohire NC, Yadav AV. Chitosan-based polyherbal toothpaste: as novel oral hygiene product. Indian J Dent Res Off Publ Ind Soc Dent Res. 2010 Sep;21(3):380–4.CrossRef Mohire NC, Yadav AV. Chitosan-based polyherbal toothpaste: as novel oral hygiene product. Indian J Dent Res Off Publ Ind Soc Dent Res. 2010 Sep;21(3):380–4.CrossRef
29.
go back to reference Gupta P, Agarwal N, Anup N, Manujunath BC, Bhalla A. Evaluating the anti-plaque efficacy of meswak (Salvadora persica) containing dentifrice: a triple blind controlled trial. J Pharm Bioallied Sci. 2012 Oct;4(4):282–5.PubMedPubMedCentralCrossRef Gupta P, Agarwal N, Anup N, Manujunath BC, Bhalla A. Evaluating the anti-plaque efficacy of meswak (Salvadora persica) containing dentifrice: a triple blind controlled trial. J Pharm Bioallied Sci. 2012 Oct;4(4):282–5.PubMedPubMedCentralCrossRef
30.
go back to reference Tatikonda A, Debnath S, Chauhan VS, Chaurasia VR, Taranath M, Sharma AM. Effects of herbal and non-herbal toothpastes on plaque and gingivitis: a clinical comparative study. J Int Soc Prev Community Dent. 2014 Dec;4(Suppl 2):S126–9.PubMedPubMedCentral Tatikonda A, Debnath S, Chauhan VS, Chaurasia VR, Taranath M, Sharma AM. Effects of herbal and non-herbal toothpastes on plaque and gingivitis: a clinical comparative study. J Int Soc Prev Community Dent. 2014 Dec;4(Suppl 2):S126–9.PubMedPubMedCentral
31.
go back to reference Al Habashneh R, Farasin R, Khader Y. The effect of a triclosan/copolymer/fluoride toothpaste on plaque formation, gingivitis, and dentin hypersensitivity: A single-blinded randomized clinical study. Quintessence Int Berl Ger 1985. 2017;48(2):123–130. Al Habashneh R, Farasin R, Khader Y. The effect of a triclosan/copolymer/fluoride toothpaste on plaque formation, gingivitis, and dentin hypersensitivity: A single-blinded randomized clinical study. Quintessence Int Berl Ger 1985. 2017;48(2):123–130.
32.
go back to reference Estafan D, Gultz J, Kaim JM, Khaghany K, Scherer W. Clinical efficacy of an herbal toothpaste. J Clin Dent. 1998;9(2):31–3.PubMed Estafan D, Gultz J, Kaim JM, Khaghany K, Scherer W. Clinical efficacy of an herbal toothpaste. J Clin Dent. 1998;9(2):31–3.PubMed
33.
go back to reference Pradeep AR, Agarwal E, Naik SB. Clinical and microbiologic effects of commercially available dentifrice containing aloe vera: a randomized controlled clinical trial. J Periodontol. 2012 Jun;83(6):797–804.PubMedCrossRef Pradeep AR, Agarwal E, Naik SB. Clinical and microbiologic effects of commercially available dentifrice containing aloe vera: a randomized controlled clinical trial. J Periodontol. 2012 Jun;83(6):797–804.PubMedCrossRef
34.
go back to reference SL da S P, YCM P, Bastos TC, PNB A, da Costa FN. Clinical effect of a gel containing Lippia sidoides on plaque and gingivitis control. Eur J Dent. 2013 Jan;7(1):28–34. SL da S P, YCM P, Bastos TC, PNB A, da Costa FN. Clinical effect of a gel containing Lippia sidoides on plaque and gingivitis control. Eur J Dent. 2013 Jan;7(1):28–34.
35.
go back to reference Pourabbas R, Delazar A, ChitsazMT. The effect of German chamomile mouthwash on dental plaque and gingival inflammation. Iran J Pharm Res 2010 Nov 20;0(0):105–109. Pourabbas R, Delazar A, ChitsazMT. The effect of German chamomile mouthwash on dental plaque and gingival inflammation. Iran J Pharm Res 2010 Nov 20;0(0):105–109.
36.
go back to reference Shetty PR, Setty SB, Kamat SS, Aldarti AS, Shetty SN. Comparison of the antigingivitis and antiplaque efficacy of the herboral (herbal extract) mouthwash with chlorhexidine and listerine mouthwashes: a clinical study. Pak Oral Dent J. 2013;33(1). Shetty PR, Setty SB, Kamat SS, Aldarti AS, Shetty SN. Comparison of the antigingivitis and antiplaque efficacy of the herboral (herbal extract) mouthwash with chlorhexidine and listerine mouthwashes: a clinical study. Pak Oral Dent J. 2013;33(1).
38.
go back to reference Vangipuram S, Jha A, Bhashyam M. Comparative efficacy of aloe vera mouthwash and chlorhexidine on periodontal health: a randomized controlled trial. J Clin Exp Dent. 2016;8(4):e442–7.PubMedPubMedCentral Vangipuram S, Jha A, Bhashyam M. Comparative efficacy of aloe vera mouthwash and chlorhexidine on periodontal health: a randomized controlled trial. J Clin Exp Dent. 2016;8(4):e442–7.PubMedPubMedCentral
39.
go back to reference Jain P, Sontakke P, Walia S, Yadav P, Biswas G, Kaur D. Assessment of the efficacy of licorice versus 0.2% chlorhexidine oral rinse on plaque-induced gingivitis: A randomized clinical trial. Indian J Oral Health Res. 2017;3(1):15–8.CrossRef Jain P, Sontakke P, Walia S, Yadav P, Biswas G, Kaur D. Assessment of the efficacy of licorice versus 0.2% chlorhexidine oral rinse on plaque-induced gingivitis: A randomized clinical trial. Indian J Oral Health Res. 2017;3(1):15–8.CrossRef
40.
go back to reference Van der Weijden GA, Timmer CJ, Timmerman MF, Reijerse E, Mantel MS, van der Velden U. The effect of herbal extracts in an experimental mouthrinse on established plaque and gingivitis. J Clin Periodontol. 1998 May;25(5):399–403.PubMedCrossRef Van der Weijden GA, Timmer CJ, Timmerman MF, Reijerse E, Mantel MS, van der Velden U. The effect of herbal extracts in an experimental mouthrinse on established plaque and gingivitis. J Clin Periodontol. 1998 May;25(5):399–403.PubMedCrossRef
41.
go back to reference Charles CH, Mostler KM, Bartels LL, Mankodi SM. Comparative antiplaque and antigingivitis effectiveness of a chlorhexidine and an essential oil mouthrinse: 6-month clinical trial. J Clin Periodontol. 2004 Oct;31(10):878–84.PubMedCrossRef Charles CH, Mostler KM, Bartels LL, Mankodi SM. Comparative antiplaque and antigingivitis effectiveness of a chlorhexidine and an essential oil mouthrinse: 6-month clinical trial. J Clin Periodontol. 2004 Oct;31(10):878–84.PubMedCrossRef
42.
go back to reference Lauten JD, Boyd L, Hanson MB, Lillie D, Gullion C, Madden TE. A clinical study: Melaleuca, Manuka, Calendula and green tea mouth rinse. Phytother Res PTR. 2005 Nov;19(11):951–7.PubMedCrossRef Lauten JD, Boyd L, Hanson MB, Lillie D, Gullion C, Madden TE. A clinical study: Melaleuca, Manuka, Calendula and green tea mouth rinse. Phytother Res PTR. 2005 Nov;19(11):951–7.PubMedCrossRef
43.
go back to reference Löe H. The Gingival Index, the Plaque Index and the Retention Index Systems. J Periodontol. 1967 Dec;38(6):Suppl:610–616.CrossRef Löe H. The Gingival Index, the Plaque Index and the Retention Index Systems. J Periodontol. 1967 Dec;38(6):Suppl:610–616.CrossRef
44.
go back to reference Turesky S, Gilmore ND, Glickman I. Reduced plaque formation by the chloromethyl analogue of victamine C. J Periodontol. 1970 Jan;41(1):41–3.PubMedCrossRef Turesky S, Gilmore ND, Glickman I. Reduced plaque formation by the chloromethyl analogue of victamine C. J Periodontol. 1970 Jan;41(1):41–3.PubMedCrossRef
45.
go back to reference Silness J, Loe H. PERIODONTAL DISEASE IN PREGNANCY. II. CORRELATION BETWEEN ORAL HYGIENE AND PERIODONTAL CONDTION. Acta Odontol Scand. 1964 Feb;22:121–35.PubMedCrossRef Silness J, Loe H. PERIODONTAL DISEASE IN PREGNANCY. II. CORRELATION BETWEEN ORAL HYGIENE AND PERIODONTAL CONDTION. Acta Odontol Scand. 1964 Feb;22:121–35.PubMedCrossRef
46.
go back to reference Albandar JM, Rams TE. Global epidemiology of periodontal diseases: an overview. Periodontol. 2002;29:7–10.CrossRef Albandar JM, Rams TE. Global epidemiology of periodontal diseases: an overview. Periodontol. 2002;29:7–10.CrossRef
48.
go back to reference Southern EN, McCombs GB, Tolle SL, Marinak K. The comparative effects of 0.12% chlorhexidine and herbal oral rinse on dental plaque-induced gingivitis. J Dent Hyg JDH. 2006;80(1):12.PubMed Southern EN, McCombs GB, Tolle SL, Marinak K. The comparative effects of 0.12% chlorhexidine and herbal oral rinse on dental plaque-induced gingivitis. J Dent Hyg JDH. 2006;80(1):12.PubMed
49.
go back to reference Vahabi S, Najafi E, Alizadeh S. In vitro antimicrobial effects of some herbal essences against oral pathogens. J Med Plants Res. 2011;5(19):4870–8. Vahabi S, Najafi E, Alizadeh S. In vitro antimicrobial effects of some herbal essences against oral pathogens. J Med Plants Res. 2011;5(19):4870–8.
50.
go back to reference Shaheen SS, Reddy P, null H, Reddy S, Doshi D, Kulkarni S, et al. Antimicrobial efficacy of ten commercially available herbal dentifrices against specific Oral microflora - in vitro study. J Clin Diagn Res JCDR. 2015 Apr;9(4):ZC42–6.PubMed Shaheen SS, Reddy P, null H, Reddy S, Doshi D, Kulkarni S, et al. Antimicrobial efficacy of ten commercially available herbal dentifrices against specific Oral microflora - in vitro study. J Clin Diagn Res JCDR. 2015 Apr;9(4):ZC42–6.PubMed
51.
go back to reference Kanth MR, Prakash AR, Sreenath G, Reddy VS, Huldah S. Efficacy of specific plant products on microorganisms causing dental caries. J Clin Diagn Res JCDR. 2016 Dec;10(12):ZM01–3.PubMed Kanth MR, Prakash AR, Sreenath G, Reddy VS, Huldah S. Efficacy of specific plant products on microorganisms causing dental caries. J Clin Diagn Res JCDR. 2016 Dec;10(12):ZM01–3.PubMed
52.
go back to reference Seneviratne CJ, Zhang CF, Samaranayake LP. Dental plaque biofilm in oral health and disease. Chin J Dent Res Off J Sci Sect Chin Stomatol Assoc CSA. 2011;14(2):87–94. Seneviratne CJ, Zhang CF, Samaranayake LP. Dental plaque biofilm in oral health and disease. Chin J Dent Res Off J Sci Sect Chin Stomatol Assoc CSA. 2011;14(2):87–94.
53.
go back to reference Wu-Yuan CD, Green L, Birch WX. In vitro screening of Chinese medicinal toothpastes: their effects on growth and plaque formation of mutans streptococci. Caries Res. 1990;24(3):198–202.PubMedCrossRef Wu-Yuan CD, Green L, Birch WX. In vitro screening of Chinese medicinal toothpastes: their effects on growth and plaque formation of mutans streptococci. Caries Res. 1990;24(3):198–202.PubMedCrossRef
54.
go back to reference Van Strydonck DAC, Slot DE, Van der Velden U, Van der Weijden F. Effect of a chlorhexidine mouthrinse on plaque, gingival inflammation and staining in gingivitis patients: a systematic review. J Clin Periodontol. 2012 Nov;39(11):1042–55.PubMedCrossRef Van Strydonck DAC, Slot DE, Van der Velden U, Van der Weijden F. Effect of a chlorhexidine mouthrinse on plaque, gingival inflammation and staining in gingivitis patients: a systematic review. J Clin Periodontol. 2012 Nov;39(11):1042–55.PubMedCrossRef
55.
go back to reference Osso D, Kanani N. Antiseptic mouth rinses: an update on comparative effectiveness, risks and recommendations. J Dent Hyg JDH. 2013 Feb;87(1):10–8.PubMed Osso D, Kanani N. Antiseptic mouth rinses: an update on comparative effectiveness, risks and recommendations. J Dent Hyg JDH. 2013 Feb;87(1):10–8.PubMed
56.
go back to reference Van Leeuwen MP, Slot DE, Van der Weijden GA. Essential oils compared to chlorhexidine with respect to plaque and parameters of gingival inflammation: a systematic review. J Periodontol. 2011. Feb;82(2):174–94.PubMedCrossRef Van Leeuwen MP, Slot DE, Van der Weijden GA. Essential oils compared to chlorhexidine with respect to plaque and parameters of gingival inflammation: a systematic review. J Periodontol. 2011. Feb;82(2):174–94.PubMedCrossRef
57.
go back to reference Corbet EF, Tam JO, Zee KY, Wong MC, Lo EC, Mombelli AW, et al. Therapeutic effects of supervised chlorhexidine mouthrinses on untreated gingivitis. Oral Dis. 1997 Mar;3(1):9–18.PubMedCrossRef Corbet EF, Tam JO, Zee KY, Wong MC, Lo EC, Mombelli AW, et al. Therapeutic effects of supervised chlorhexidine mouthrinses on untreated gingivitis. Oral Dis. 1997 Mar;3(1):9–18.PubMedCrossRef
Metadata
Title
Effectiveness of herbal oral care products in reducing dental plaque & gingivitis – a systematic review and meta-analysis
Authors
Chandrashekar Janakiram
Ramanarayanan Venkitachalam
Paul Fontelo
Timothy J. Iafolla
Bruce A. Dye
Publication date
01-12-2020
Publisher
BioMed Central
Keyword
Care
Published in
BMC Complementary Medicine and Therapies / Issue 1/2020
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-020-2812-1

Other articles of this Issue 1/2020

BMC Complementary Medicine and Therapies 1/2020 Go to the issue