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Published in: BMC Health Services Research 1/2021

Open Access 01-12-2021 | Care | Research

Characteristics and resource utilization of high-cost users in the intensive care unit: a population-based cohort study

Authors: Claudia Dziegielewski, Robert Talarico, Haris Imsirovic, Danial Qureshi, Yasmeen Choudhri, Peter Tanuseputro, Laura H. Thompson, Kwadwo Kyeremanteng

Published in: BMC Health Services Research | Issue 1/2021

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Abstract

Background

Healthcare expenditure within the intensive care unit (ICU) is costly. A cost reduction strategy may be to target patients accounting for a disproportionate amount of healthcare spending, or high-cost users. This study aims to describe high-cost users in the ICU, including health outcomes and cost patterns.

Methods

We conducted a population-based retrospective cohort study of patients with ICU admissions in Ontario from 2011 to 2018. Patients with total healthcare costs in the year following ICU admission (including the admission itself) in the upper 10th percentile were defined as high-cost users. We compared characteristics and outcomes including length of stay, mortality, disposition, and costs between groups.

Results

Among 370,061 patients included, 37,006 were high-cost users. High-cost users were 64.2 years old, 58.3% male, and had more comorbidities (41.2% had ≥3) when likened to non-high cost users (66.1 years old, 57.2% male, 27.9% had ≥3 comorbidities). ICU length of stay was four times greater for high-cost users compared to non-high cost users (22.4 days, 95% confidence interval [CI] 22.0–22.7 days vs. 5.56 days, 95% CI 5.54–5.57 days). High-cost users had lower in-hospital mortality (10.0% vs.14.2%), but increased dispositioning outside of home (77.4% vs. 42.2%) compared to non-high-cost users. Total healthcare costs were five-fold higher for high-cost users ($238,231, 95% CI $237,020–$239,442) compared to non-high-cost users ($45,155, 95% CI $45,046–$45,264). High-cost users accounted for 37.0% of total healthcare costs.

Conclusion

High-cost users have increased length of stay, lower in-hospital mortality, and higher total healthcare costs when compared to non-high-cost users. Further studies into cost patterns and predictors of high-cost users are necessary to identify methods of decreasing healthcare expenditure.
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Literature
1.
go back to reference National Health Expenditure Trends, 1975 to 2019. Canadian Institute for Health Information. Toronto; 2019. National Health Expenditure Trends, 1975 to 2019. Canadian Institute for Health Information. Toronto; 2019.
2.
go back to reference Canadian Institute for Health Information. Care in Canadian ICUs. Toronto: Canadian Institute for Health Information; 2016. Canadian Institute for Health Information. Care in Canadian ICUs. Toronto: Canadian Institute for Health Information; 2016.
3.
go back to reference Angus DC, Kelley MA, Schmitz RJ, White A, Popovich JJ. (COMPACCS) For the C on M for P and CCS. Current and projected workforce requirements for Care of the Critically ill and Patients with pulmonary disease: can we meet the requirements of an aging population? JAMA. 2000;284(21):2762–70.PubMedCrossRef Angus DC, Kelley MA, Schmitz RJ, White A, Popovich JJ. (COMPACCS) For the C on M for P and CCS. Current and projected workforce requirements for Care of the Critically ill and Patients with pulmonary disease: can we meet the requirements of an aging population? JAMA. 2000;284(21):2762–70.PubMedCrossRef
4.
go back to reference Needham DM, Bronskill SE, Calinawan JR, Sibbald WJ, Pronovost PJ, Laupacis A. Projected incidence of mechanical ventilation in Ontario to 2026: preparing for the aging baby boomers. Crit Care Med. 2005;33(3):574–9.PubMedCrossRef Needham DM, Bronskill SE, Calinawan JR, Sibbald WJ, Pronovost PJ, Laupacis A. Projected incidence of mechanical ventilation in Ontario to 2026: preparing for the aging baby boomers. Crit Care Med. 2005;33(3):574–9.PubMedCrossRef
5.
go back to reference Ideas and opportunities for bending the health care cost curve: advice for the government of Ontario. The Ontario Association of Community Care Access Centres (OACCAC); the Ontario Federation of Community Mental Health and Addiction Programs (OFCCMHAP) and. Canada: The Ontario Hospital Association (OHA); 2010. Ideas and opportunities for bending the health care cost curve: advice for the government of Ontario. The Ontario Association of Community Care Access Centres (OACCAC); the Ontario Federation of Community Mental Health and Addiction Programs (OFCCMHAP) and. Canada: The Ontario Hospital Association (OHA); 2010.
6.
go back to reference Rais S, Ardal S, Chechulin Y, Bains N, Malikov K. High-cost users of Ontario’s healthcare services. Healthc Policy. 2013;9(1):44–51.PubMedPubMedCentral Rais S, Ardal S, Chechulin Y, Bains N, Malikov K. High-cost users of Ontario’s healthcare services. Healthc Policy. 2013;9(1):44–51.PubMedPubMedCentral
7.
go back to reference Reid R, Evans R, Barer M, Sheps S, Kerluke K, McGrail K, et al. Conspicuous consumption: characterizing high users of physician Services in one Canadian Province. J Health Serv Res Policy. 2003;8(4):215–24.PubMedCrossRef Reid R, Evans R, Barer M, Sheps S, Kerluke K, McGrail K, et al. Conspicuous consumption: characterizing high users of physician Services in one Canadian Province. J Health Serv Res Policy. 2003;8(4):215–24.PubMedCrossRef
8.
go back to reference Roos NP, Shapiro E, Tate R. Does a small minority of elderly account for a majority of health care expenditures?: a sixteen-year perspective. Milbank Q. 1989;67(3–4):347–69.PubMedCrossRef Roos NP, Shapiro E, Tate R. Does a small minority of elderly account for a majority of health care expenditures?: a sixteen-year perspective. Milbank Q. 1989;67(3–4):347–69.PubMedCrossRef
9.
go back to reference Ronksley PE, Kobewka DM, McKay JA, Rothwell DM, Mulpuru S, Forster AJ. Clinical characteristics and preventable acute care spending among a high cost inpatient population. BMC Health Serv Res. 2016;16(165):1–10. Ronksley PE, Kobewka DM, McKay JA, Rothwell DM, Mulpuru S, Forster AJ. Clinical characteristics and preventable acute care spending among a high cost inpatient population. BMC Health Serv Res. 2016;16(165):1–10.
10.
go back to reference Wodchis WP, Austin PC, Henry DA. A 3-year study of high-cost users of health care. Can Med Assoc J. 2016;188(3):182–8.CrossRef Wodchis WP, Austin PC, Henry DA. A 3-year study of high-cost users of health care. Can Med Assoc J. 2016;188(3):182–8.CrossRef
11.
go back to reference Kim YJ, Park H. Improving prediction of high-cost health care users with medical check-up data. Big Data. 2019;7(3):163–75.PubMedCrossRef Kim YJ, Park H. Improving prediction of high-cost health care users with medical check-up data. Big Data. 2019;7(3):163–75.PubMedCrossRef
12.
go back to reference Lee NS, Whitman N, Vakharia N, Taksler GB, Rothberg MB. High-cost patients: hot-spotters Don’t explain the half of it. J Gen Intern Med. 2017;32(1):28–34.PubMedCrossRef Lee NS, Whitman N, Vakharia N, Taksler GB, Rothberg MB. High-cost patients: hot-spotters Don’t explain the half of it. J Gen Intern Med. 2017;32(1):28–34.PubMedCrossRef
13.
go back to reference Expenditure estimates for the Ministry of Health and Long-Term Care (2018–19). Government of Ontario. Canada. 2019. Expenditure estimates for the Ministry of Health and Long-Term Care (2018–19). Government of Ontario. Canada. 2019.
14.
go back to reference Reardon PM, Fernando SM, Van Katwyk S, Thavorn K, Kobewka D, Tanuseputro P, et al. Characteristics, outcomes, and cost patterns of high-cost patients in the intensive care unit. Crit Care Res Pract. 2018:1–7. Reardon PM, Fernando SM, Van Katwyk S, Thavorn K, Kobewka D, Tanuseputro P, et al. Characteristics, outcomes, and cost patterns of high-cost patients in the intensive care unit. Crit Care Res Pract. 2018:1–7.
15.
go back to reference Welton JM, Meyer AA, Mandelkehr L, Fakhry SM, Jarr S. Outcomes of and resource consumption by high-cost patients in the intensive care unit. Am J Crit Care. 2002;11(5):467–73.PubMedCrossRef Welton JM, Meyer AA, Mandelkehr L, Fakhry SM, Jarr S. Outcomes of and resource consumption by high-cost patients in the intensive care unit. Am J Crit Care. 2002;11(5):467–73.PubMedCrossRef
16.
go back to reference Evans J, Kobewka D, Thavorn K, D’Egidio G, Rosenberg E, Kyeremanteng K. The impact of reducing intensive care unit length of stay on hospital costs: evidence from a tertiary Care Hospital in Canada. Can J Anesth. 2018;65(6):627–35.PubMedCrossRef Evans J, Kobewka D, Thavorn K, D’Egidio G, Rosenberg E, Kyeremanteng K. The impact of reducing intensive care unit length of stay on hospital costs: evidence from a tertiary Care Hospital in Canada. Can J Anesth. 2018;65(6):627–35.PubMedCrossRef
17.
go back to reference Montgomery CL, Rolfson DB, Bagshaw SM. Frailty and the association between long-term recovery after intensive care unit admission. Crit Care Clin. 2018;34(4):527–47.PubMedCrossRef Montgomery CL, Rolfson DB, Bagshaw SM. Frailty and the association between long-term recovery after intensive care unit admission. Crit Care Clin. 2018;34(4):527–47.PubMedCrossRef
18.
go back to reference Rashidi B, Kobewka DM, Campbell DJT, Forster AJ, Ronksley PE. Clinical factors contributing to high cost hospitalizations in a Canadian tertiary care Centre. BMC Health Serv Res. 2017;17(1):777.PubMedPubMedCentralCrossRef Rashidi B, Kobewka DM, Campbell DJT, Forster AJ, Ronksley PE. Clinical factors contributing to high cost hospitalizations in a Canadian tertiary care Centre. BMC Health Serv Res. 2017;17(1):777.PubMedPubMedCentralCrossRef
19.
go back to reference Rosella LC, Kornas K, Yao Z, Manuel DG, Bornbaum C, Fransoo R, et al. Predicting high health care resource utilization in a single-payer public health care system: development and validation of the high resource user population risk tool (HRUPoRT). Med Care. 2018;56(10):61–9.CrossRef Rosella LC, Kornas K, Yao Z, Manuel DG, Bornbaum C, Fransoo R, et al. Predicting high health care resource utilization in a single-payer public health care system: development and validation of the high resource user population risk tool (HRUPoRT). Med Care. 2018;56(10):61–9.CrossRef
20.
go back to reference Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–83.PubMedCrossRef Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–83.PubMedCrossRef
21.
go back to reference Fernando SM, Qureshi D, Tanuseputro P, Fan E, Munshi L, Rochwerg B, et al. Mortality and costs following extracorporeal membrane oxygenation in critically ill adults: a population-based cohort study. Intensive Care Med. 2019;45(11):1580–9.PubMedCrossRef Fernando SM, Qureshi D, Tanuseputro P, Fan E, Munshi L, Rochwerg B, et al. Mortality and costs following extracorporeal membrane oxygenation in critically ill adults: a population-based cohort study. Intensive Care Med. 2019;45(11):1580–9.PubMedCrossRef
22.
go back to reference Wodchis WP, Bushmeneva K, Nikitovic M, McKillop I. Guidelines on person-level costing using administrative databases in Ontario. Working paper series. Toronto: health system performance research Network; 2013. Wodchis WP, Bushmeneva K, Nikitovic M, McKillop I. Guidelines on person-level costing using administrative databases in Ontario. Working paper series. Toronto: health system performance research Network; 2013.
24.
go back to reference Dasta JF, McLaughlin TP, Mody SH, Piech CT. Daily cost of an intensive care unit day: the contribution of mechanical ventilation. Crit Care Med. 2005;33(6):1266–71.PubMedCrossRef Dasta JF, McLaughlin TP, Mody SH, Piech CT. Daily cost of an intensive care unit day: the contribution of mechanical ventilation. Crit Care Med. 2005;33(6):1266–71.PubMedCrossRef
25.
go back to reference Kyeremanteng K, Wan C, D'Egidio G, Neilipovitz D. Approach to economic analysis in critical care. J Crit Care. 2016;36:92–6.PubMedCrossRef Kyeremanteng K, Wan C, D'Egidio G, Neilipovitz D. Approach to economic analysis in critical care. J Crit Care. 2016;36:92–6.PubMedCrossRef
26.
go back to reference Chin-Yee N, D’Egidio G, Thavorn K, Heyland D, Kyeremanteng K. Cost analysis of the very elderly admitted to intensive care units. Crit Care. 2017;2:109.CrossRef Chin-Yee N, D’Egidio G, Thavorn K, Heyland D, Kyeremanteng K. Cost analysis of the very elderly admitted to intensive care units. Crit Care. 2017;2:109.CrossRef
27.
go back to reference Kaier K, Heister T, Motschall E, Hehn P, Bluhmki T, Wolkewitz M. Impact of mechanical ventilation on the daily costs of ICU care: a systematic review and Meta regression. Epidemiol Infect. 2019;147:e314.PubMedPubMedCentralCrossRef Kaier K, Heister T, Motschall E, Hehn P, Bluhmki T, Wolkewitz M. Impact of mechanical ventilation on the daily costs of ICU care: a systematic review and Meta regression. Epidemiol Infect. 2019;147:e314.PubMedPubMedCentralCrossRef
28.
go back to reference Karabatsou D, Tsironi M, Tsigou E, Boutzouka E, Katsoulas T, Baltopoulos G. Variable cost of ICU care, a Micro-costing analysis. Intensive Crit Care Nurs. 2016;35:66–73.PubMedCrossRef Karabatsou D, Tsironi M, Tsigou E, Boutzouka E, Katsoulas T, Baltopoulos G. Variable cost of ICU care, a Micro-costing analysis. Intensive Crit Care Nurs. 2016;35:66–73.PubMedCrossRef
29.
go back to reference TEAM Study Investigators, Hodgson C, Bellomo R, Berney S, Bailey M, Buhr H, et al. Early Mobilization and Recovery in Mechanically Ventilated Patients in the ICU: A Bi-national, Multi-centre, Prospective Cohort Study. Crit Care. 2015;19(1):81.CrossRef TEAM Study Investigators, Hodgson C, Bellomo R, Berney S, Bailey M, Buhr H, et al. Early Mobilization and Recovery in Mechanically Ventilated Patients in the ICU: A Bi-national, Multi-centre, Prospective Cohort Study. Crit Care. 2015;19(1):81.CrossRef
30.
go back to reference Brummel NE, Bell SP, Girard TD, Pandharipande PP, Jackson JC, Morandi A, et al. Frailty and subsequent disability and mortality among patients with critical illness. Am J Respir Crit Care Med. 2017;196(1):64–72.PubMedPubMedCentralCrossRef Brummel NE, Bell SP, Girard TD, Pandharipande PP, Jackson JC, Morandi A, et al. Frailty and subsequent disability and mortality among patients with critical illness. Am J Respir Crit Care Med. 2017;196(1):64–72.PubMedPubMedCentralCrossRef
31.
go back to reference Hendin A, Tanuseputro P, McIsaac DI, Hsu AT, Smith GA, Begum J, et al. Frailty is associated with decreased time spent at home after critical illness: a population-based study. J Intensive Care Med. 2021;36(8):937–44. Hendin A, Tanuseputro P, McIsaac DI, Hsu AT, Smith GA, Begum J, et al. Frailty is associated with decreased time spent at home after critical illness: a population-based study. J Intensive Care Med. 2021;36(8):937–44.
32.
go back to reference Jutan N, Langlois L, Damiano N. Seniors and alternative level of care: building on our knowledge. Healthc Q. 2013;16(3):7–10.PubMedCrossRef Jutan N, Langlois L, Damiano N. Seniors and alternative level of care: building on our knowledge. Healthc Q. 2013;16(3):7–10.PubMedCrossRef
33.
go back to reference Covinsky KE, Palmer RM, Fortinsky RH, Counsell SR, Stewart AL, Kresevic D, et al. Loss of independence in activities of daily living in older adults hospitalized with medical illnesses: increased vulnerability with age. J Am Geriatr Soc. 2003 Apr;51(4):451–8.PubMedCrossRef Covinsky KE, Palmer RM, Fortinsky RH, Counsell SR, Stewart AL, Kresevic D, et al. Loss of independence in activities of daily living in older adults hospitalized with medical illnesses: increased vulnerability with age. J Am Geriatr Soc. 2003 Apr;51(4):451–8.PubMedCrossRef
34.
go back to reference Walker D. Caring for our aging population and addressing alternate level of care. Toronto: Ontario Ministry of Health and Long-Term Care; 2011. Walker D. Caring for our aging population and addressing alternate level of care. Toronto: Ontario Ministry of Health and Long-Term Care; 2011.
35.
go back to reference Qureshi D, Isenberg S, Tanuseputro P, Moineddin R, Quinn K, Meaney C, et al. Describing the characteristics and healthcare use of high-cost acute care users at the end of life: a Pan-Canadian population-based study. BMC Health Serv Res. 2020;20(1):997.PubMedPubMedCentralCrossRef Qureshi D, Isenberg S, Tanuseputro P, Moineddin R, Quinn K, Meaney C, et al. Describing the characteristics and healthcare use of high-cost acute care users at the end of life: a Pan-Canadian population-based study. BMC Health Serv Res. 2020;20(1):997.PubMedPubMedCentralCrossRef
36.
go back to reference Rosella LC, Fitzpatrick T, Wodchis WP, Calzavara A, Manson H, Vivek G. High-cost health care users in Ontario, Canada: demographic, socio-economic, and health status characteristics. BMC Health Serv Res. 2014;14:532.PubMedPubMedCentralCrossRef Rosella LC, Fitzpatrick T, Wodchis WP, Calzavara A, Manson H, Vivek G. High-cost health care users in Ontario, Canada: demographic, socio-economic, and health status characteristics. BMC Health Serv Res. 2014;14:532.PubMedPubMedCentralCrossRef
37.
go back to reference Wammes JJG, van der Wees PJ, Tanke MAC, Westert GP, Jeurissen PPT. Systematic review of high-cost Patients' characteristics and healthcare utilisation. BMJ Open. 2018;8(9):e023113.PubMedPubMedCentralCrossRef Wammes JJG, van der Wees PJ, Tanke MAC, Westert GP, Jeurissen PPT. Systematic review of high-cost Patients' characteristics and healthcare utilisation. BMJ Open. 2018;8(9):e023113.PubMedPubMedCentralCrossRef
38.
go back to reference Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. The association of frailty with Post-ICU disability, nursing home admission, and mortality: a longitudinal study. Chest. 2018;153(6):1378–86.PubMedPubMedCentralCrossRef Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. The association of frailty with Post-ICU disability, nursing home admission, and mortality: a longitudinal study. Chest. 2018;153(6):1378–86.PubMedPubMedCentralCrossRef
39.
go back to reference Flaatten H, De Lange DW, Morandi A, Andersen FH, Artigas A, Bertolini G, et al. The impact of frailty on ICU and 30-day mortality and the level of care in very elderly patients (≥ 80 years). Intensive Care Med. 2017;43(12):1820–8.PubMedCrossRef Flaatten H, De Lange DW, Morandi A, Andersen FH, Artigas A, Bertolini G, et al. The impact of frailty on ICU and 30-day mortality and the level of care in very elderly patients (≥ 80 years). Intensive Care Med. 2017;43(12):1820–8.PubMedCrossRef
40.
go back to reference Figueroa JF, Zhou X, Jha AK. Characteristics and spending patterns of persistently high-cost Medicare patients. Health Aff. 2019;38(1):107–14.CrossRef Figueroa JF, Zhou X, Jha AK. Characteristics and spending patterns of persistently high-cost Medicare patients. Health Aff. 2019;38(1):107–14.CrossRef
43.
go back to reference Kyeremanteng K, Gagnon LP, Thavorn K, Heyland D, D’Egidio G. The impact of palliative care consultation in the ICU on length of stay: a systematic review and cost evaluation. J Intensive Care Med. 2018;33(6):346–53.PubMedCrossRef Kyeremanteng K, Gagnon LP, Thavorn K, Heyland D, D’Egidio G. The impact of palliative care consultation in the ICU on length of stay: a systematic review and cost evaluation. J Intensive Care Med. 2018;33(6):346–53.PubMedCrossRef
44.
go back to reference Scheunemann LP, McDevitt M, Carson SS, Hanson LC. Randomized, controlled trials of interventions to improve communication in intensive care: a systematic review. Chest. 2011;139(3):543–54.PubMedCrossRef Scheunemann LP, McDevitt M, Carson SS, Hanson LC. Randomized, controlled trials of interventions to improve communication in intensive care: a systematic review. Chest. 2011;139(3):543–54.PubMedCrossRef
45.
go back to reference Muratov S, Lee J, Holbrook A, Paterson JM, Guertin JR, Mbuagbaw L, et al. Unplanned index hospital admissions among new older high-cost health care users in Ontario: a population-based matched cohort study. CMAJ Open. 2019;7(3):E537–45.PubMedPubMedCentralCrossRef Muratov S, Lee J, Holbrook A, Paterson JM, Guertin JR, Mbuagbaw L, et al. Unplanned index hospital admissions among new older high-cost health care users in Ontario: a population-based matched cohort study. CMAJ Open. 2019;7(3):E537–45.PubMedPubMedCentralCrossRef
46.
go back to reference Sherry M, Wolff JL, Ballreich J, DuGoff E, Davis K, Anderson G. Bridging the silos of service delivery for high-need, High-Cost Individuals. Popul Health Manag. 2016;19:421–8.PubMedPubMedCentralCrossRef Sherry M, Wolff JL, Ballreich J, DuGoff E, Davis K, Anderson G. Bridging the silos of service delivery for high-need, High-Cost Individuals. Popul Health Manag. 2016;19:421–8.PubMedPubMedCentralCrossRef
47.
go back to reference Tricco AC, Antony J, Ivers NM, Ashoor HM, Khan PA, Blondal E, et al. Effectiveness of quality improvement strategies for coordination of care to reduce use of health care services: a systematic review and Meta-analysis. CMAJ. 2014;186(15):E568–78.PubMedPubMedCentralCrossRef Tricco AC, Antony J, Ivers NM, Ashoor HM, Khan PA, Blondal E, et al. Effectiveness of quality improvement strategies for coordination of care to reduce use of health care services: a systematic review and Meta-analysis. CMAJ. 2014;186(15):E568–78.PubMedPubMedCentralCrossRef
48.
go back to reference de Oliveira C, Cheng J, Kurdyak P. Determining preventable acute care spending among high-cost patients in a single-payer public health care system. Eur J Health Econ. 2019;20(6):869–78.PubMedCrossRef de Oliveira C, Cheng J, Kurdyak P. Determining preventable acute care spending among high-cost patients in a single-payer public health care system. Eur J Health Econ. 2019;20(6):869–78.PubMedCrossRef
49.
go back to reference McLaughlin AM, Hardt J, Canavan JB, Donnelly MB. Determining the economic cost of ICU treatment: a prospective “Micro-costing” study. Intensive Care Med. 2009;35(12):2135–40.PubMedCrossRef McLaughlin AM, Hardt J, Canavan JB, Donnelly MB. Determining the economic cost of ICU treatment: a prospective “Micro-costing” study. Intensive Care Med. 2009;35(12):2135–40.PubMedCrossRef
Metadata
Title
Characteristics and resource utilization of high-cost users in the intensive care unit: a population-based cohort study
Authors
Claudia Dziegielewski
Robert Talarico
Haris Imsirovic
Danial Qureshi
Yasmeen Choudhri
Peter Tanuseputro
Laura H. Thompson
Kwadwo Kyeremanteng
Publication date
01-12-2021
Publisher
BioMed Central
Keyword
Care
Published in
BMC Health Services Research / Issue 1/2021
Electronic ISSN: 1472-6963
DOI
https://doi.org/10.1186/s12913-021-07318-y

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