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01-10-2003 | Review Article

Cardiovascular deconditioning in microgravity: some possible countermeasures

Authors: G. Antonutto, P. E. di Prampero

Published in: European Journal of Applied Physiology | Issue 3-4/2003

Abstract

Microgravity is an extreme environment inducing relevant adaptive changes in the human body, especially after prolonged periods of exposure. Since the early sixties, numerous studies on the effects of microgravity, during manned Space flights, have produced an increasing amount of information concerning its physiological effects, globally defined "deconditioning". Microgravity deconditioning of the cardiovascular system (CVD) is briefly reviewed. It consists of: (1) a decrease of circulating blood and interstitial fluid volumes, (2) a decrease of arterial blood diastolic pressure, (3) a decrease of ventricular stroke volume, (4) a decrease of the estimated left ventricular mass and (5) resetting of the carotid baroreceptors. The negative effects of microgravity deconditioning manifest themselves mostly upon the reentry to Earth. They consist mainly of: (1) dizziness, (2) increased heart rate and heart palpitations, (3) an inability to assume the standing position (orthostatic intolerance), (4) pre-syncopal feelings due to postural stress and (5) reduced exercise capacity. To avoid these drawbacks several countermeasures have been proposed; they will be briefly mentioned with emphasis on the "Twin Bikes System" (TBS). This consists of two coupled bicycles operated by astronauts and counter-rotating along the inner wall of a cylindrical Space module, thus generating a centrifugal force vector, mimicking gravity.

Antonutto G, Capelli C, di Prampero PE (1991) Pedalling in Space as a countermeasure to microgravity deconditioning. Microgravity Q 1:93–101PubMed

Antonutto G, Linnasson D, di Prampero PE (1993) On Earth evaluation of neurovestibular tolerance to centrifuge simulated artificial gravity in humans. Physiologist 36 [Suppl. 1]:S85–S87

Antonutto G, Girardis M, Tuniz D, Petri E, Capelli C (1994) Assessment of cardiac output from noninvasive determination of arterial pressure profile in subjects at rest. Eur J Appl Physiol 69:183–188

Antonutto G, Girardis M, Tuniz D, di Prampero PE (1995) Non-invasive assessment of cardiac output from arterial pressure profiles during exercise. Eur J Appl Physiol 72:18–24

Antonutto G, Capelli C, Girardis M, Zamparo P, di Prampero PE (1999) Effects of microgravity on maximal power of lower limbs during very short efforts in humans. J Appl Physiol 86:85–92PubMed

Benson AJ (1988) Motion sickness. In: Ernsting J, King P (eds) Aviation medicine. Butterworth, London, pp 318–338

Bungo MW, Johnson PC Jr (1983) Cardiovascular examinations and observations of deconditioning during Space Shuttle Orbital Flight Test Program. Aviat Space Environ Med 54:1001–1004PubMed

Bungo MW, Goldwater DJ, Popp RL, Sandler H (1987) Echocardiographic evaluation of Space Shuttle crewmembers. J Appl Physiol 62:278–283PubMed

Burton RR (1997) Artificial gravity in Space flight. J Gravit Physiol 4:P17–P20PubMed

Burton RR, Meeker LJ (1994) Taking gravity to Space. J Gravit Physiol 1:P15–P18PubMed

Capelli C, Rosa G, Butti F, Ferretti G, Veicsteinas A, di Prampero PE (1993) Energy cost and efficiency of riding aerodynamic bicycles. Eur J Appl Physiol 67:144–149

Cardùs D (1994) Artificial gravity in space and in medical research. J Gravit Physiol 1:P19–P22PubMed

Cautero M, Antonutto G, Fusi S, Tam E, di Prampero PE, Linnarsson D, Ferretti G, Capelli C (2003) Oxygen uptake at the onset of step-exercise before and after short duration bed rest in humans. J Gravit Physiol (in press)

Charles JB, Lathers CM (1991) Cardiovascular adaptation to spaceflight. J Clin Pharmacol 31:1001–1023PubMed

Charles JB, Bungo MW, Fortner GW (1994) Cardiopulmonary function. In: Nicogossian AE, Leach Huntoon C, Pool SM (eds) Space physiology and medicine. Lea and Febiger, Philadelphia, pp 286–304

Churchill SE, Bungo MW (1997) Response of the cardiovascular system to spaceflight. In: Churchill SE (ed) Fundamentals of space life sciences, vol 1. Krieger, Malabar Fla., pp 41–63

Fahri LE, Nesarajah MS, Olszowka AJ, Metildi LA, Ellis AK (1976) Cardiac output determination by a simple one step rebreathing technique. Respir Physiol 28:141–159CrossRefPubMed

Ferretti G, Girardis M, Moia C, Antonutto G (1998) Effects of prolonged bed rest on cardiovascular oxygen transport during submaximal exercise in humans. Eur J Appl Physiol 78:398–402CrossRef

Ferretti G, Berg HE, Minetti AE, Moia C, Rampichini S, Narici MV (2000) Maximal instantaneous muscular power after prolonged bed rest in humans. J Appl Physiol 90:431–435

Fortney SM, Schneider VS, Greenleaf JE (1996) The physiology of bed rest. In: Fregly MJ, Blatteis CM (eds) Handbook of physiology, section 4, vol 2. Environmental physiology. American Physiological Society, Bethesda, Md. and Oxford University Press, Oxford, pp 889–939

Fritsch JM, Charles JB, Bennett BS, Jones MM, Eckberg DL (1992) Short-duration space flight impairs human carotid baroreceptor-cardiac reflex responses. J Appl Physiol 73:664–671PubMed

Gazenko OG, Schilzenko EB, Yegorov AD (1985) Cardiovascular changes in prolonged spaceflights. IAF Preprint, 36th IAF Conference, Stockholm (S). Pergamon, New York

Greenleaf JE, Gundo DP, Watenpaugh DE, Mulenburg GM, McKenzie MA, Looft-Wilson R, Hargens AR (1997) Cycle-powered short radius (1.9 m) centrifuge: effect of exercise versus passive acceleration on heart rate in humans. NASA Technical Memorandum 110433

Hall TW (1994) The architecture of artificial-gravity environments for long-duration space habitation. Doctoral dissertation, University of Michigan, UMI, Ann Arbor

Hastreiter D, Young LR (1997) Effects of gravity gradient on human cardiovascular responses. J Gravit Physiol 4:P23–P26PubMed

Henry WL, Epstein SE, Griffith LM, Goldstein RE, Redwood DR (1977) Effect of prolonged space flight on cardiac function and dimension. In: Johnston RS, Dietlein LF (eds) Biomedical results from Skylab (NASA SP-377). US Government Printing Office, Washington DC, pp 366–371

Hinghofer-Szalkay HC (1996) Physiology of cardiovascular, respiratory, interstitial, endocrine, immune and muscular systems. In: Moore D, Bie P, Oser H (eds) Biological and medical research in Space. Springer, Berlin Heidelberg New York, pp 107–153

Hoffler GW, Bergmen SA, Nicogossian AE (1977) In-flight lower limb measurement. In: Nicogossian AE (ed) The Apollo–Soyuz Test Project medical report (NASA SP-411). US Government Printing Office, Washington DC, pp 63–68

Johnson RL, Driscoll TB, Le Balnc AD (1977) Blood volume changes. In: Johnston RS, Dietlein LF (eds) Biomedical results from Skylab (NASA SP-377). US Government Printing Office, Washington DC, pp 284–312

Keller TS, Strauss AM, Szpalsky M (1992) Prevention of bone loss and muscle atrophy during manned space flight. Microgravity Q 2:89–102PubMed

Lackner JR, Graybiel A (1986) The effective intensity of Coriolis cross-coupling stimulation is gravitoinertial force dependent: implication for space motion sickness. Aviat Space Environ Med 57:229–235PubMed

Lane HW, Alfrey CP, Driscoll TB, Smith SM, Nyquist LE (1996) Control of red blood cell mass during space flight. J Gravit Physiol, 3:87–90

Leach CS, Rambaut PC (1977) Biochemical responses of the Skylab crewmen: an overview. In: Johnston RS, Dietlein LF (eds) Biomedical results from Skylab (NASA SP-377). US Government Printing Office, Washington DC, pp 204–216

Leach CS, Inners LD, Charles JB (1991) Changes in total body water during spaceflight. J Clin Pharmacol 31:1001–1006PubMed

Leach Huntoon CL, Cintròn NM, Whitson PA (1994) Endocrine and biochemical functions. In: Nicogossian AE, Leach Huntoon C, Pool SM (eds) Space physiology and medicine. Lea and Febiger, Philadelphia, pp 334–350

Linnarsson D, Sundberg CJ, Tedner B, Haruna Y, Karemaker JM, Antonutto G, di Prampero PE (1996) Blood pressure and heart rate response to sudden changes of gravity during exercise. Am J Physiol 270:H2132–H2142PubMed

Minetti AE (2002) On the mechanical power of joint extensions as affected by the change in muscle force (or cross sectional area), ceteris paribus. Eur J Appl Physiol 86:363–369

Nicogossian AE, Pool SM, JJ Uri (1994) Historical perspectives. In: Nicogossian AE, Leach Huntoon C, Pool SM (eds) Space physiology and medicine. Lea and Febiger, Philadelphia, pp 3–49

di Prampero PE (2000) Cycling on Earth, in space, on the Moon. Eur J Appl Phisiol 82:345–360CrossRef

di Prampero PE, Antonutto G (1996) Effects of microgravity on muscle power: some possible countermeasures. In: ESA Symposium Proceeding on "Space Station Utilization", Darmstadt, ESA-SP-385, pp 103–106

di Prampero PE, Antonutto G (1997) Cycling in Space to simulate gravity. Int J Sports Med 18:S324–S326PubMed

di Prampero PE, Narici MV (2003) Muscles in microgravity: from fibres to human motion. J Biomech 36:403–412CrossRefPubMed

Rowell LB (1986) Human circulation. Regulation during physical stress. Oxford University Press, New York, pp 137–173

Spaak J, Sundblad P, Linnarsson D (2001) Impaired pressor response after spaceflight and bed rest: evidence for cardiovascular dysfunction. Eur J Appl Physiol 85:49–55CrossRefPubMed

Sundblad P, Spaak J, Linnarsson D (2000) Cardiovascular response to upright and supine exercise in humans after 6 weeks of head-down tilt (−6 degrees). Eur J Appl Physiol 83:303–309CrossRefPubMed

Vernikos J (1997) Artificial gravity intermittent centrifugation as a space flight countermeasure. J Gravit Physiol 4:P13–P16PubMed

Vil-Viliams IF, Kotovskaya AR, Shipov AA (1997) Biomedical aspects of artificial gravity. J Gravit Physiol 4:P27–P28PubMed

White WJ (1965) Space-based centrifuge. Proceedings of 1st Symposium on the Role of the Vestibular Organs in the Exploration of Space. U.S. Naval School of Aviation Medicine, Pensacola, Fla., and NASA, Washington DC, pp 209–213

Yegorov AD, Alferova IV, Polyakiva AP (1988a) State of cardiodynamics under conditions of long-term weightlessness. Kosm Biol Aviakosm Med 22:4–7

Yegorov AD, Itsekhovskiy OG, Alferova IV, Turchaninova VF, Polenova AP, Golubchikova ZA, Domracheva MV, Lyamin VR, Turbasov VD (1988b) Study of cardiovascular system of Salyut-6 prime crew. USSR Space Life Digest 14:18–19

Zamparo P, Minetti AE, di Prampero PE (2002) Interplay among the changes of muscle strength, cross-sectional area and maximal explosive power: theory and facts. Eur J Appl Physiol 88:193–202CrossRefPubMed

Zange J, Mueller K, Schuber M, Wackerhage H, Hoffmann U, Guenther RW, Adam G, Neuerburg JM, Sinitsyn VE, Bacharev AO, Belichenko OI (1997) Changes in calf muscle performance, energy metabolism and muscle volume caused by long term stay on space station MIR. Int J Sports Med 18 [Suppl. 4]:S308–S309

Title: Cardiovascular deconditioning in microgravity: some possible countermeasures
Authors: G. Antonutto
P. E. di Prampero
Publication date: 01-10-2003
Publisher: Springer-Verlag
Published in: European Journal of Applied Physiology / Issue 3-4/2003
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-003-0884-5

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Cardiovascular deconditioning in microgravity: some possible countermeasures

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