Top

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

Published in:

01-12-2020 | Cardiopulmonary Resuscitation | Original research

Associations of therapeutic hypothermia with clinical outcomes in patients receiving ECPR after cardiac arrest: systematic review with meta-analysis

Authors: Xi Chen, Zhen Zhen, Jia Na, Qin Wang, Lu Gao, Yue Yuan

Published in: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine | Issue 1/2020

Abstract

Background

Therapeutic hypothermia has been recommended for eligible patients after cardiac arrest (CA) in order to improve outcomes. Up to now, several comparative observational studies have evaluated the combined use of extracorporeal cardiopulmonary resuscitation (ECPR) and therapeutic hypothermia in adult patients with CA. However, the effects of therapeutic hypothermia in adult CA patients receiving ECPR are inconsistent.

Methods

Relevant studies in English databases (PubMed, ISI web of science, OVID, and Embase) were systematically searched up to September 2019. Odds ratios (ORs) from eligible studies were extracted and pooled to summarize the associations of therapeutic hypothermia with favorable neurological outcomes and survival in adult CA patients receiving ECPR.

Results

13 articles were included in the present meta-analysis study. There were nine studies with a total of 806 cases reporting the association of therapeutic hypothermia with neurological outcomes in CA patients receiving ECPR. Pooling analysis suggested that therapeutic hypothermia was significantly associated with favorable neurological outcomes in overall (N = 9, OR = 3.507, 95%CI = 2.194–5.607, P < 0.001, fixed-effects model) and in all subgroups according to control type, regions, sample size, CA location, ORs obtained methods, follow-up period, and modified Newcastle Ottawa Scale (mNOS) scores. There were nine studies with a total of 806 cases assessing the association of therapeutic hypothermia with survival in CA patients receiving ECPR. After pooling the ORs, therapeutic hypothermia was found to be significantly associated with survival in overall (N = 9, OR = 2.540, 95%CI = 1.245–5.180, P = 0.010, random-effects model) and in some subgroups. Publication bias was found when evaluating the association of therapeutic hypothermia with neurological outcomes in CA patients receiving ECPR. Additional trim-and-fill analysis estimated four “missing” studies, which adjusted the effect size to 2.800 (95%CI = 1.842–4.526, P < 0.001, fixed-effects model) for neurological outcomes.

Conclusions

Therapeutic hypothermia may be associated with favorable neurological outcomes and survival in adult CA patients undergoing ECPR. However, the result should be treated carefully because it is a synthesis of low-level evidence and other limitations exist in present study. It is necessary to perform randomized controlled trials to validate our result before considering the result in clinical practices.

Available only for authorised users

Zheng ZJ, Croft JB, Giles WH, Mensah GA. Sudden cardiac death in the United States, 1989 to 1998. Circ. 2001;104(18):2158–63.CrossRef

Fox CS, Evans JC, Larson MG, Kannel WB, Levy D. Temporal trends in coronary heart disease mortality and sudden cardiac death from 1950 to 1999: the Framingham heart study. Circ. 2004;110(5):522–7.CrossRef

Girotra S, van Diepen S, Nallamothu BK, Carrel M, Vellano K, Anderson ML, et al. Regional variation in out-of-hospital cardiac arrest survival in the United States. Circ. 2016;133(22):2159–68.CrossRef

Girotra S, Nallamothu BK, Spertus JA, Li Y, Krumholz HM, Chan PS, et al. Trends in survival after in-hospital cardiac arrest. N Engl J Med. 2012;367(20):1912–20.PubMedPubMedCentralCrossRef

Goldberger ZD, Chan PS, Berg RA, Kronick SL, Cooke CR, Lu M, et al. Duration of resuscitation efforts and survival after in-hospital cardiac arrest: an observational study. Lancet. 2012;380(9852):1473–81.PubMedPubMedCentralCrossRef

Pozzi M, Koffel C, Armoiry X, Pavlakovic I, Neidecker J, Prieur C, et al. Extracorporeal life support for refractory out-of-hospital cardiac arrest: should we still fight for? A single-Centre, 5-year experience. Int J Cardiol. 2016;204:70–6.PubMedCrossRef

Chen YS, Lin JW, Yu HY, Ko WJ, Jerng JS, Chang WT, et al. Cardiopulmonary resuscitation with assisted extracorporeal life-support versus conventional cardiopulmonary resuscitation in adults with in-hospital cardiac arrest: an observational study and propensity analysis. Lancet. 2008;372(9638):554–61.PubMedCrossRef

Ha TS, Yang JH, Cho YH, Chung CR, Park CM, Jeon K, et al. Clinical outcomes after rescue extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest. Emerg Med J. 2017;34(2):107–11.PubMedCrossRef

Maekawa K, Tanno K, Hase M, Mori K, Asai Y. Extracorporeal cardiopulmonary resuscitation for patients with out-of-hospital cardiac arrest of cardiac origin: a propensity-matched study and predictor analysis. Crit Care Med. 2013;41(5):1186–96.PubMedCrossRef

10.

Kim SJ, Kim HJ, Lee HY, Ahn HS, Lee SW. Comparing extracorporeal cardiopulmonary resuscitation with conventional cardiopulmonary resuscitation: a meta-analysis. Resuscitation. 2016;103:106–16.PubMedCrossRef

11.

Blumenstein J, Leick J, Liebetrau C, Kempfert J, Gaede L, Gross S, et al. Extracorporeal life support in cardiovascular patients with observed refractory in-hospital cardiac arrest is associated with favourable short and long-term outcomes: a propensity-matched analysis. Eur Heart J Acute Cardiovasc Care. 2016;5(7):13–22.PubMedCrossRef

12.

Ouweneel DM, Schotborgh JV, Limpens J, Sjauw KD, Engstrom AE, Lagrand WK, et al. Extracorporeal life support during cardiac arrest and cardiogenic shock: a systematic review and meta-analysis. Intensive Care Med. 2016;42(12):1922–34.PubMedPubMedCentralCrossRef

13.

Stretch R, Sauer CM, Yuh DD, Bonde P. National trends in the utilization of short-term mechanical circulatory support: incidence, outcomes, and cost analysis. J Am Coll Cardiol. 2014;64(14):1407–15.PubMedCrossRef

14.

Karagiannidis C, Brodie D, Strassmann S, Stoelben E, Philipp A, Bein T, et al. Extracorporeal membrane oxygenation: evolving epidemiology and mortality. Intensive Care Med. 2016;42(5):889–96.PubMedCrossRef

15.

Brooks SC, Anderson ML, Bruder E, Daya MR, Gaffney A, Otto CW, et al. Part 6: alternative techniques and ancillary devices for cardiopulmonary resuscitation: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care. Circ. 2015;132(18 Suppl 2):S436–43.CrossRef

16.

Bednarczyk JM, White CW, Ducas RA, Golian M, Nepomuceno R, Hiebert B, et al. Resuscitative extracorporeal membrane oxygenation for in hospital cardiac arrest: a Canadian observational experience. Resuscitation. 2014;85(12):1713–9.PubMedCrossRef

17.

Siao FY, Chiu CC, Chiu CW, Chen YC, Chen YL, Hsieh YK, et al. Managing cardiac arrest with refractory ventricular fibrillation in the emergency department: conventional cardiopulmonary resuscitation versus extracorporeal cardiopulmonary resuscitation. Resuscitation. 2015;92:70–6.PubMedCrossRef

18.

Sakamoto S, Taniguchi N, Nakajima S, Takahashi A. Extracorporeal life support for cardiogenic shock or cardiac arrest due to acute coronary syndrome. Ann Thorac Surg. 2012;94(1):1–7.PubMedCrossRef

19.

Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002;346(8):557–63.PubMedCrossRef

20.

Hypothermia after Cardiac Arrest Study G. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002;346(8):549–56.CrossRef

21.

Arrich J, Holzer M, Havel C, Mullner M, Herkner H. Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation. Cochrane Database Syst Rev. 2016;2:CD004128.PubMed

22.

Howes D, Gray SH, Brooks SC, Boyd JG, Djogovic D, Golan E, et al. Canadian guidelines for the use of targeted temperature management (therapeutic hypothermia) after cardiac arrest: a joint statement from the Canadian critical care society (CCCS), Canadian Neurocritical care society (CNCCS), and the Canadian critical care trials group (CCCTG). Resuscitation. 2016;98:48–63.PubMedCrossRef

23.

Nikolaou NI, Arntz HR, Bellou A, Beygui F, Bossaert LL, Cariou A, et al. European resuscitation council guidelines for resuscitation 2015 section 8. Initial Manage Acute Coron Syndr Resuscitation. 2015;95:264–77.

24.

Nolan JP, Soar J, Cariou A, Cronberg T, Moulaert VR, Deakin CD, et al. European resuscitation council and European Society of Intensive Care Medicine Guidelines for post-resuscitation care 2015: section 5 of the European resuscitation council guidelines for resuscitation 2015. Resuscitation. 2015;95:202–22.PubMedCrossRef

25.

Kagawa E, Dote K, Kato M, Sasaki S, Nakano Y, Kajikawa M, et al. Should we emergently Revascularize occluded coronaries for cardiac arrest? Rapid-response extracorporeal membrane oxygenation and intra-arrest percutaneous coronary intervention. Circ. 2012;126(13):1605–13.CrossRef

26.

Kim SJ, Jung JS, Park JH, Park JS, Hong YS, Lee SW. An optimal transition time to extracorporeal cardiopulmonary resuscitation for predicting good neurological outcome in patients with out-of-hospital cardiac arrest: a propensity-matched study. Critical Care. 2014;18(5).

27.

Kagawa E, Dote K, Kato M, Sasaki S, Oda N, Nakano Y, et al. Do lower target temperatures or prolonged cooling provide improved outcomes for comatose survivors of cardiac arrest treated with hypothermia? J Am Heart Assoc. 2015;4(9).

28.

Choi DH, Kim YJ, Ryoo SM, Sohn CH, Ahn S, Seo DW, et al. Extracorporeal cardiopulmonary resuscitation among patients with out-of-hospital cardiac arrest. Clin Exp Emerg Med. 2016;3(3):132–8.PubMedPubMedCentralCrossRef

29.

Lee JJ, Han SJ, Kim HS, Hong KS, Choi HH, Park KT, et al. Out-of-hospital cardiac arrest patients treated with cardiopulmonary resuscitation using extracorporeal membrane oxygenation: focus on survival rate and neurologic outcome. Scand J Trauma Resuscitation Emerg Med. 2016;24.

30.

Dennis M, McCanny P, D'Souza M, Forrest P, Burns B, Lowe DA, et al. Extracorporeal cardiopulmonary resuscitation for refractory cardiac arrest: a multicentre experience. Int J Cardiol. 2017;231:131–6.PubMedCrossRef

31.

Pang PYK, Wee GHL, Huang MJ, Hoo AEE, Sheriff IMT, Lim SL, et al. Therapeutic hypothermia may improve neurological outcomes in extracorporeal life support for adult cardiac arrest. Heart Lung Circ. 2017;26(8):817–24.PubMedCrossRef

32.

Yukawa T, Kashiura M, Sugiyama K, Tanabe T, Hamabe Y. Neurological outcomes and duration from cardiac arrest to the initiation of extracorporeal membrane oxygenation in patients with out-of-hospital cardiac arrest: a retrospective study. Scand J Trauma Resusc Emerg Med. 2017;25(1):95.PubMedPubMedCentralCrossRef

33.

Goto T, Morita S, Kitamura T, Natsukawa T, Sawano H, Hayashi Y, et al. Impact of extracorporeal cardiopulmonary resuscitation on outcomes of elderly patients who had out-of-hospital cardiac arrests: a single-Centre retrospective analysis. BMJ Open. 2018;8(5):e019811.PubMedPubMedCentralCrossRef

34.

Otani T, Sawano H, Natsukawa T, Nakashima T, Oku H, Gon C, et al. Low-flow time is associated with a favorable neurological outcome in out-of-hospital cardiac arrest patients resuscitated with extracorporeal cardiopulmonary resuscitation. J Crit Care. 2018;48:15–20.PubMedCrossRef

35.

Han KS, Kim SJ, Lee EJ, Jung JS, Park JH, Lee SW. Experience of extracorporeal cardiopulmonary resuscitation in a refractory cardiac arrest patient at the emergency department. Clin Cardiol. 2019;42(4):459–66.PubMedPubMedCentralCrossRef

36.

Ryu JA, Chung CR, Cho YH, Sung K, Jeon K, Suh GY, et al. Neurologic outcomes in patients who undergo extracorporeal cardiopulmonary resuscitation. Ann Thorac Surg. 2019;108(3):749–55.PubMedCrossRef

37.

Stub D, Bernard S, Pellegrino V, Smith K, Walker T, Sheldrake J, et al. Refractory cardiac arrest treated with mechanical CPR, hypothermia, ECMO and early reperfusion (the CHEER trial). Resuscitation. 2015;86:88–94.PubMedCrossRef

38.

Prohl J, Rother J, Kluge S, de Heer G, Liepert J, Bodenburg S, et al. Prediction of short-term and long-term outcomes after cardiac arrest: a prospective multivariate approach combining biochemical, clinical, electrophysiological, and neuropsychological investigations. Crit Care Med. 2007;35(5):1230–7.PubMedCrossRef

39.

D R, L N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.CrossRef

40.

Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50(4):1088–101.PubMedCrossRef

41.

Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. Bmj. 1997;315(7109):629–34.PubMedPubMedCentralCrossRef

42.

Pang PY, Wee GH, Hoo AE, Sheriff IM, Lim SL, Tan TE, et al. Therapeutic hypothermia in adult patients receiving extracorporeal life support: early results of a randomized controlled study. J Cardiothorac Surg. 2016;11:43.PubMedPubMedCentralCrossRef

43.

Ryu JA, Cho YH, Sung K, Choi SH, Yang JH, Choi JH, et al. Predictors of neurological outcomes after successful extracorporeal cardiopulmonary resuscitation. BMC Anesthesiol. 2015;15.

44.

Ryu JA, Lee YH, Chung CR, Cho YH, Sung K, Jeon K, et al. Prognostic value of computed tomography score in patients after extracorporeal cardiopulmonary resuscitation. Crit Care. 2018;22(1):323.PubMedPubMedCentralCrossRef

45.

Kagawa E, Inoue I, Kawagoe T, Ishihara M, Shimatani Y, Kurisu S, et al. Assessment of outcomes and differences between in- and out-of-hospital cardiac arrest patients treated with cardiopulmonary resuscitation using extracorporeal life support. Resuscitation. 2010;81(8):968–73.PubMedCrossRef

46.

Kim YS, Cho YH, Sung K, Ryu JA, Chung CR, Suh GY, et al. Target Temperature Management May Not Improve Clinical Outcomes of Extracorporeal Cardiopulmonary Resuscitation. J Intensive Care Med. 2019;34(10):790–6.PubMedCrossRef

47.

Lee SW, Han KS, Park JS, Lee JS, Kim SJ. Prognostic indicators of survival and survival prediction model following extracorporeal cardiopulmonary resuscitation in patients with sudden refractory cardiac arrest. Ann Intensive Care. 2017;7(1):87.PubMedPubMedCentralCrossRef

48.

Kim Y, Ryu J-A, Kim YO, Cho YH, Yang JH, Lee S, et al. Prognostic value of optic nerve sheath diameter in patients after extracorporeal cardiopulmonary resuscitation. J Neurointensive Care. 2019;2(1):17–24.CrossRef

49.

Cheng HH, Rajagopal SK, Sansevere AJ, McDavitt E, Wigmore D, Mecklosky J, et al. Post-arrest therapeutic hypothermia in pediatric patients with congenital heart disease. Resuscitation. 2018;126:83–9.PubMedPubMedCentralCrossRef

50.

Meert KL, Guerguerian AM, Barbaro R, Slomine BS, Christensen JR, Berger J, et al. Extracorporeal cardiopulmonary resuscitation: one-year survival and neurobehavioral outcome among infants and children with in-hospital cardiac arrest. Crit Care Med. 2018;12:12.

51.

Torres-Andres F, Fink EL, Bell MJ, Sharma MS, Yablonsky EJ, Sanchez-De-Toledo J. Survival and long-term functional outcomes for children with cardiac arrest treated with extracorporeal cardiopulmonary resuscitation. Pediatr Crit Care Med. 2018;19(5):451–8.PubMedPubMedCentralCrossRef

52.

Doherty DR, Parshuram CS, Gaboury I, Hoskote A, Lacroix J, Tucci M, et al. Hypothermia therapy after pediatric cardiac arrest. Circ. 2009;119(11):1492–U57.CrossRef

53.

Huang SC, Wu ET, Chen YS, Chang CI, Chiu IS, Wang SS, et al. Extracorporeal membrane oxygenation rescue for cardiopulmonary resuscitation in pediatric patients. Crit Care Med. 2008;36(5):1607–13.PubMedCrossRef

54.

Topjian AA, Telford R, Holubkov R, Nadkarni VM, Berg RA, Dean JM, et al. The association of early post-resuscitation hypotension with discharge survival following targeted temperature management for pediatric in-hospital cardiac arrest. Resuscitation. 2019;141:24–34.PubMedCrossRefPubMedCentral

55.

Cuevas Guaman M, Lucke AM, Hagan JL, Kaiser JR. Bleeding complications and mortality in neonates receiving therapeutic hypothermia and extracorporeal membrane oxygenation. Am J Perinatol. 2018;35(3):271–6.PubMedCrossRef

56.

Bouglé A, Le Gall A, Dumas F, Geri G, Malissin I, Voicu S, et al. ExtraCorporeal life support for cardiac ARrest in patients with post cardiac arrest syndrome: the ECCAR study. Arch Cardiovasc Dis. 2019;112(4):253–60.PubMedCrossRef

57.

Avalli L, Mauri T, Citerio G, Migliari M, Coppo A, Caresani M, et al. New treatment bundles improve survival in out-of-hospital cardiac arrest patients: a historical comparison. Resuscitation. 2014;85(9):1240–4.PubMedCrossRef

58.

Nagao K, Hayashi N, Kanmatsuse K, Arima K, Ohtsuki J, Kikushima K, et al. Cardiopulmonary cerebral resuscitation using emergency cardiopulmonary bypass, coronary reperfusion therapy and mild hypothermia in patients with cardiac arrest outside the hospital. J Am Coll Cardiol. 2000;36(3):776–83.PubMedCrossRef

59.

Sharma AS, Pijls RW, Weerwind PW, Delnoij TS, de Jong WC, Gorgels AP, et al. Out-of-hospital cardiac arrest: the prospect of E-CPR in the Maastricht region. Neth Hear J. 2016;24(2):120–6.CrossRef

60.

Reynolds JC, Grunau BE, Elmer J, Rittenberger JC, Sawyer KN, Kurz MC, et al. Prevalence, natural history, and time-dependent outcomes of a multi-center north American cohort of out-of-hospital cardiac arrest extracorporeal CPR candidates. Resuscitation. 2017;117:24–31.PubMedCrossRef

61.

Wang CH, Chou NK, Becker LB, Lin JW, Yu HY, Chi NH, et al. Improved outcome of extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest--a comparison with that for extracorporeal rescue for in-hospital cardiac arrest. Resuscitation. 2014;85(9):1219–24.PubMedCrossRef

62.

Avalli L, Maggioni E, Formica F, Redaelli G, Migliari M, Scanziani M, et al. Favourable survival of in-hospital compared to out-of-hospital refractory cardiac arrest patients treated with extracorporeal membrane oxygenation: An Italian tertiary care Centre experience. Resuscitation. 2012;83(5):579–83.PubMedCrossRef

63.

Fagnoul D, Taccone FS, Belhaj A, Rondelet B, Argacha JF, Vincent JL, et al. Extracorporeal life support associated with hypothermia and normoxemia in refractory cardiac arrest. Resuscitation. 2013;84(11):1519–24.PubMedCrossRef

64.

Sakamoto T, Morimura N, Nagao K, Asai Y, Yokota H, Nara S, et al. Extracorporeal cardiopulmonary resuscitation versus conventional cardiopulmonary resuscitation in adults with out-of-hospital cardiac arrest: a prospective observational study. Resuscitation. 2014;85(6):762–8.PubMedCrossRef

65.

Stub D, Nehme Z, Bernard S, Lijovic M, Kaye DM, Smith K. Exploring which patients without return of spontaneous circulation following ventricular fibrillation out-of-hospital cardiac arrest should be transported to hospital? Resuscitation. 2014;85(3):326–31.PubMedCrossRef

66.

Ryu JA, Park TK, Chung CR, Cho YH, Sung K, Suh GY, et al. Association between Body Temperature Patterns and Neurological Outcomes after Extracorporeal Cardiopulmonary Resuscitation. Plos One. 2017;12(1).PubMedPubMedCentralCrossRef

67.

Liem S, Cavarocchi NC, Hirose H. Comparing in-patient extracorporeal cardiopulmonary resuscitation to standard cardiac treatment group of extracorporeal membrane oxygenation patients: 8 years of experience at a single institution. Perfusion,267659119860735 (2019).

68.

Lamhaut L, Tea V, Raphalen JH, An K, Dagron C, Jouffroy R, et al. Coronary lesions in refractory out of hospital cardiac arrest (OHCA) treated by extra corporeal pulmonary resuscitation (ECPR). Resuscitation. 2018;126:154–9.PubMedCrossRef

69.

Nakashima T, Noguchi T, Tahara Y, Nishimura K, Ogata S, Yasuda S, et al. Patients with refractory out-of-cardiac arrest and sustained ventricular fibrillation as candidates for extracorporeal cardiopulmonary resuscitation ― prospective multi-center observational study ―. Circ J. 2019;83(5):1011–8.PubMedCrossRef

70.

Bhardwaj A, Miano T, Geller B, Milewski RC, Williams M, Bermudez C, et al. Venovenous extracorporeal membrane oxygenation for patients with return of spontaneous circulation after cardiac arrest owing to acute respiratory distress syndrome. J Cardiothorac Vasc Anesth. 2019;33(8):2216–20.PubMedCrossRef

71.

Kaushal M, Schwartz J, Gupta N, Im J, Leff J, Jakobleff WA, et al. Patient demographics and extracorporeal membranous oxygenation (ECMO)-related complications associated with survival to discharge or 30-day survival in adult patients receiving Venoarterial (VA) and Venovenous (VV) ECMO in a quaternary care Urban Center. J Cardiothorac Vasc Anesth. 2019;33(4):910–7.PubMedCrossRef

72.

Park JH, Song KJ, Shin SD, Ro YS, Hong KJ. Time from arrest to extracorporeal cardiopulmonary resuscitation and survival after out-of-hospital cardiac arrest. Emerg Med Australas. 2019.

73.

Zakhary B, Nanjayya VB, Sheldrake J, Collins K, Ihle JF, Pellegrino V. Predictors of mortality after extracorporeal cardiopulmonary resuscitation. Crit Care Resusc. 2018;20(3):223–30.PubMed

74.

Nagao K, Kikushima K, Watanabe K, Tachibana E, Tominaga Y, Tada K, et al. Early induction of hypothermia during cardiac arrest improves neurological outcomes in patients with out-of-hospital cardiac arrest who undergo emergency cardiopulmonary bypass and percutaneous coronary intervention. Circ J. 2010;74(1):77–85.PubMedCrossRef

75.

Leick J, Liebetrau C, Szardien S, Fischer-Rasokat U, Willmer M, van Linden A, et al. Door-to-implantation time of extracorporeal life support systems predicts mortality in patients with out-of-hospital cardiac arrest. Clin Res Cardiol. 2013;102(9):661–9.PubMedCrossRef

76.

Deye N, Cariou A, Girardie P, Pichon N, Megarbane B, Midez P, et al. Endovascular versus external targeted temperature Management for Patients with out-of-Hospital Cardiac Arrest a Randomized, controlled study. Circ. 2015;132(3):182–93.CrossRef

77.

Peigh G, Cavarocchi N, Hirose H. Saving life and brain with extracorporeal cardiopulmonary resuscitation: a single-center analysis of in-hospital cardiac arrests. J Thorac Cardiovasc Surg. 2015;150(5):1344–9.PubMedCrossRef

78.

Lee YH, Oh YT, Ahn HC, Kim HS, Han SJ, Lee JJ, et al. The prognostic value of the grey-to-white matter ratio in cardiac arrest patients treated with extracorporeal membrane oxygenation. Resuscitation. 2016;99:50–5.PubMedCrossRef

79.

Tagami T, Matsui H, Kuno M, Moroe Y, Kaneko J, Unemoto K, et al. Early antibiotics administration during targeted temperature management after out-of-hospital cardiac arrest: a nationwide database study. Bmc Anesthesiol. 2016;16.

80.

Kim YS, Lee YJ, Won KB, Kim JW, Lee SC, Park CR, et al. Extracorporeal cardiopulmonary resuscitation with therapeutic hypothermia for prolonged refractory in-hospital cardiac arrest. Korean Circ J. 2017;47(6):939–48.PubMedPubMedCentralCrossRef

81.

Bartos JA, Carlson K, Carlson C, Raveendran G, John R, Aufderheide TP, et al. Surviving refractory out-of-hospital ventricular fibrillation cardiac arrest: critical care and extracorporeal membrane oxygenation management. Resuscitation. 2018;132:47–55.PubMedCrossRef

82.

Chouihed T, Kimmoun A, Lauvray A, Laithier FX, Jaeger D, Lemoine S, et al. Improving patient selection for refractory out of hospital cardiac arrest treated with extracorporeal LIFE support. Shock. 2018;49(1):24–8.PubMedCrossRef

83.

Jung C, Bueter S, Wernly B, Masyuk M, Saeed D, Albert A, et al. Lactate clearance predicts good neurological outcomes in cardiac arrest patients treated with extracorporeal cardiopulmonary resuscitation. J Clin Med. 2019;8(3):374.PubMedCentralCrossRef

84.

Komeyama S, Takagi K, Tsuboi H, Tsuboi S, Morita Y, Yoshida R, et al. The early initiation of extracorporeal life support may improve the neurological outcome in adults with cardiac arrest due to cardiac events. Intern Med. 2019;58(10):1391–7.PubMedPubMedCentralCrossRef

85.

Axtell AL, Funamoto M, Legassey AG, Moonsamy P, Shelton K, DA D’A, et al. Predictors of Neurologic Recovery in Patients who undergo Extracorporeal Membrane Oxygenation for Refractory Cardiac Arrest. J Cardiothorac Vasc Anesth. 2019.

86.

Froehler MT, Geocadin RG. Hypothermia for neuroprotection after cardiac arrest: mechanisms, clinical trials and patient care. J Neurol Sci. 2007;261(1–2):118–26.PubMedCrossRef

87.

Gunn AJ, Thoresen M. Hypothermic neuroprotection. NeuroRx. 2006;3(2):154–69.PubMedPubMedCentralCrossRef

88.

Soleimanpour H, Rahmani F, Golzari SE, Safari S. Main complications of mild induced hypothermia after cardiac arrest: a review article. J Cardiovasc Thorac Res. 2014;6(1):1–8.PubMedPubMedCentral

89.

Group HaCAS. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002;346(8):549–56.CrossRef

90.

Nielsen N, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, et al. Targeted temperature management at 33 degrees C versus 36 degrees C after cardiac arrest. N Engl J Med. 2013;369(23):2197–206.PubMedCrossRef

91.

Haneya A, Philipp A, Diez C, Schopka S, Bein T, Zimmermann M, et al. A 5-year experience with cardiopulmonary resuscitation using extracorporeal life support in non-postcardiotomy patients with cardiac arrest. Resuscitation. 2012;83(11):1331–7.PubMedCrossRef

Title: Associations of therapeutic hypothermia with clinical outcomes in patients receiving ECPR after cardiac arrest: systematic review with meta-analysis
Authors: Xi Chen
Zhen Zhen
Jia Na
Qin Wang
Lu Gao
Yue Yuan
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Cardiopulmonary Resuscitation
ECMO
ECMO
Published in: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine / Issue 1/2020
Electronic ISSN: 1757-7241
DOI: https://doi.org/10.1186/s13049-019-0698-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Associations of therapeutic hypothermia with clinical outcomes in patients receiving ECPR after cardiac arrest: systematic review with meta-analysis

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2020

Establishment of an extracorporeal cardio-pulmonary resuscitation program in Berlin – outcomes of 254 patients with refractory circulatory arrest

Description of Emergency Medical Services, treatment of cardiac arrest patients and cardiac arrest registries in Europe

Autoresuscitation (Lazarus phenomenon) after termination of cardiopulmonary resuscitation - a scoping review

How should nonspecific complaints be defined? Comment to: “nonspecific complaints (NSCs) in the emergency department”

National Early Warning Score 2 (NEWS2) on admission predicts severe disease and in-hospital mortality from Covid-19 – a prospective cohort study

Changing role of EMS –analyses of non-conveyed and conveyed patients in Finland