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Published in:

04-07-2023

Cardioprotective Effects of the 4-Week Aerobic Running Exercises Before Treatment with Doxorubicin in Rats

Authors: Talita Cristina Rodrigues Pereira, Thiago Montes Fidale, Lucas Costa Guimarães, Simone Ramos Deconte, Gustavo Cavinato Herrera, Antônio Vicente Mundim, Eduardo de Sales Cabral, Paulo Ricardo Lopes, Fernanda Rodrigues de Souza, Luiz Duarte de Ulhôa Rocha Júnior, Alinne Tatiane Faria Silva, Elmiro Santos Resende

Published in: Cardiovascular Toxicology | Issue 7-8/2023

Abstract

Doxorubicin is associated with cardiotoxicity, and physical exercise seeks to minimize the toxic effects of doxorubicin through physiological cardiac remodeling, as well as the reduction of oxidative stress, evidenced by previous studies. This study aimed to analyze whether running training before treatment with doxorubicin influences tolerance to physical exertion and cardiotoxicity. Thirty-nine male Wistar rats, aged 90 days and weighing between 250 and 300 g, were divided into 4 groups: Control (C), Doxorubicin (D), Trained (T), and Trained + Doxorubicin (TD). Animals in groups T and DT were submitted to treadmill running for 3 weeks, 5 times a week at 18 m/min for 20–30 min before treatment with doxorubicin. Animals in groups D and DT received intraperitoneal injections of doxorubicin hydrochloride three times a week for two weeks, reaching a total cumulative dose of 7.50 mg/kg. Our results show an increase in total collagen fibers in the D group (p = 0.01), but no increase in the TD group, in addition to the attenuation of the number of cardiac mast cells in the animals in the TD group (p = 0.05). The animals in the TD group showed maintenance of tolerance to exertion compared to group D. Therefore, running training attenuated the cardiac damage caused by the treatment with doxorubicin, in addition to maintaining the tolerance to exertion in the rats.

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Title: Cardioprotective Effects of the 4-Week Aerobic Running Exercises Before Treatment with Doxorubicin in Rats
Authors: Talita Cristina Rodrigues Pereira
Thiago Montes Fidale
Lucas Costa Guimarães
Simone Ramos Deconte
Gustavo Cavinato Herrera
Antônio Vicente Mundim
Eduardo de Sales Cabral
Paulo Ricardo Lopes
Fernanda Rodrigues de Souza
Luiz Duarte de Ulhôa Rocha Júnior
Alinne Tatiane Faria Silva
Elmiro Santos Resende
Publication date: 04-07-2023
Publisher: Springer US
Published in: Cardiovascular Toxicology / Issue 7-8/2023
Print ISSN: 1530-7905
Electronic ISSN: 1559-0259
DOI: https://doi.org/10.1007/s12012-023-09798-2

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Cardioprotective Effects of the 4-Week Aerobic Running Exercises Before Treatment with Doxorubicin in Rats

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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