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Magnetic Resonance Materials in Physics, Biology and Medicine

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Open Access 01-06-2019 | Cardiomyopathy | Research Article

The feasibility of a novel limited field of view spiral cine DENSE sequence to assess myocardial strain in dilated cardiomyopathy

Authors: Upasana Tayal, Ricardo Wage, Pedro Filipe Ferreira, Sonia Nielles-Vallespin, Frederick Howard Epstein, Daniel Auger, Xiaodong Zhong, Dudley John Pennell, David Nigel Firmin, Andrew David Scott, Sanjay Kumar Prasad

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 3/2019

Abstract

Objective

Develop an accelerated cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance (CMR) sequence to enable clinically feasible myocardial strain evaluation in patients with dilated cardiomyopathy (DCM).

Materials and methods

A spiral cine DENSE sequence was modified by limiting the field of view in two dimensions using in-plane slice-selective pulses in the stimulated echo. This reduced breath hold duration from 20RR to 14RR intervals. Following phantom and pilot studies, the feasibility of the sequence to assess peak radial, circumferential, and longitudinal strain was tested in control subjects (n = 18) and then applied in DCM patients (n = 29).

Results

DENSE acquisition was possible in all participants. Elements of the data were not analysable in 1 control (6%) and 4 DCM r(14%) subjects due to off-resonance or susceptibility artefacts and low signal-to-noise ratio. Peak radial, circumferential, short-axis contour strain and longitudinal strain was reduced in DCM patients (p < 0.001 vs. controls) and strain measurements correlated with left ventricular ejection fraction (with circumferential strain r = − 0.79, p < 0.0001; with vertical long-axis strain r = − 0.76, p < 0.0001). All strain measurements had good inter-observer agreement (ICC > 0.80), except peak radial strain.

Discussion

We demonstrate the feasibility of CMR strain assessment in healthy controls and DCM patients using an accelerated cine DENSE technique. This may facilitate integration of strain assessment into routine CMR studies.

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Title: The feasibility of a novel limited field of view spiral cine DENSE sequence to assess myocardial strain in dilated cardiomyopathy
Authors: Upasana Tayal
Ricardo Wage
Pedro Filipe Ferreira
Sonia Nielles-Vallespin
Frederick Howard Epstein
Daniel Auger
Xiaodong Zhong
Dudley John Pennell
David Nigel Firmin
Andrew David Scott
Sanjay Kumar Prasad
Publication date: 01-06-2019
Publisher: Springer International Publishing
Keyword: Cardiomyopathy
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 3/2019
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-019-00735-5

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Springer Medicine

The feasibility of a novel limited field of view spiral cine DENSE sequence to assess myocardial strain in dilated cardiomyopathy

Abstract

Objective

Materials and methods

Results

Discussion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Materials and methods

Results

Discussion

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