Skip to main content
Top
Published in: BMC Emergency Medicine 1/2020

Open Access 01-12-2020 | Cardiac Syncope | Research article

Diagnostic accuracy of evaluation of suspected syncope in the emergency department: usual practice vs. ESC guidelines

Authors: Veera K. van Wijnen, Reinold O. B. Gans, Wouter Wieling, Jan C. ter Maaten, Mark P. M. Harms

Published in: BMC Emergency Medicine | Issue 1/2020

Login to get access

Abstract

Background

Syncope is a frequent reason for referral to the emergency department. After excluding a potentially life-threatening condition, the second objective is to find the cause of syncope. The objective of this study was to assess the diagnostic accuracy of the treating physician in usual practice and to compare this to the diagnostic accuracy of a standardised evaluation, consisting of thorough history taking and physical examination by a research physician.

Methods

This prospective cohort study included suspected (pre) syncope patients without an identified serious underlying condition who were assessed in the emergency department. Patients were initially seen by the initial treating physician and the usual evaluation was performed. A research physician, blinded to the findings of the initial treating physician, then performed a standardised evaluation according to the ESC syncope guidelines. Diagnostic accuracy (proportion of correct diagnoses) was determined by expert consensus after long-term follow-up.

Results

One hundred and one suspected (pre) syncope patients were included (mean age 59 ± 20 years). The usual practice of the initial treating physicians did not in most cases follow ESC syncope guidelines, with orthostatic blood pressure measurements made in only 40% of the patients. Diagnostic accuracy by the initial treating physicians was 65% (95% CI 56–74%), while standardised evaluation resulted in a diagnostic accuracy of 80% (95% CI 71–87%; p = 0.009). No life-threatening causes were missed.

Conclusions

Usual practice of the initial treating physician resulted in a diagnostic accuracy of 65%, while standardised practice, with an emphasis on thorough history taking, increased diagnostic accuracy to 80%. Results suggest that the availability of additional resources does not result in a higher diagnostic accuracy than standardised evaluation, and that history taking is the most important diagnostic test in suspected syncope patients. Netherlands Trial Registration: NTR5651. Registered 29 January 2016,https://www.trialregister.nl/trial/5532
Literature
1.
go back to reference Writing Committee Members, Shen WK, Sheldon RS, et al. 2017 ACC/AHA/HRS guideline for the evaluation and management of patients with syncope: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines and the Heart Rhythm Society, Heart Rhythm 2017;14:e155–e217. Writing Committee Members, Shen WK, Sheldon RS, et al. 2017 ACC/AHA/HRS guideline for the evaluation and management of patients with syncope: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines and the Heart Rhythm Society, Heart Rhythm 2017;14:e155–e217.
2.
go back to reference Mechanic OJ, Pascheles CY, Lopez GJ, Winans AM, Shapiro NI, Tibbles C, et al. Using the Boston Syncope observation management pathway to reduce hospital admission and adverse outcomes. West J Emerg Med. 2019;20(2):250–5.CrossRef Mechanic OJ, Pascheles CY, Lopez GJ, Winans AM, Shapiro NI, Tibbles C, et al. Using the Boston Syncope observation management pathway to reduce hospital admission and adverse outcomes. West J Emerg Med. 2019;20(2):250–5.CrossRef
3.
go back to reference Brignole M, Moya A, de Lange FJ, et al. 2018 ESC guidelines for the diagnosis and management of syncope. Eur Heart J. 2018;39:1883–948.CrossRef Brignole M, Moya A, de Lange FJ, et al. 2018 ESC guidelines for the diagnosis and management of syncope. Eur Heart J. 2018;39:1883–948.CrossRef
4.
go back to reference Linzer M, Yang EH, Estes NA 3rd, et al. Diagnosing syncope. Part 1: value of history, physical examination, and electrocardiography. Clinical efficacy assessment project of the American College of Physicians. Ann Intern Med. 1997;126:989–96.CrossRef Linzer M, Yang EH, Estes NA 3rd, et al. Diagnosing syncope. Part 1: value of history, physical examination, and electrocardiography. Clinical efficacy assessment project of the American College of Physicians. Ann Intern Med. 1997;126:989–96.CrossRef
5.
go back to reference Huff JS, Decker WW, Quinn JV, et al. Clinical policy: critical issues in the evaluation and management of adult patients presenting to the emergency department with syncope. Ann Emerg Med. 2007;49:431–44.CrossRef Huff JS, Decker WW, Quinn JV, et al. Clinical policy: critical issues in the evaluation and management of adult patients presenting to the emergency department with syncope. Ann Emerg Med. 2007;49:431–44.CrossRef
6.
go back to reference Disertori M, Brignole M, Menozzi C, et al. Management of patients with syncope referred urgently to general hospitals. Europace. 2003;5:283–91.CrossRef Disertori M, Brignole M, Menozzi C, et al. Management of patients with syncope referred urgently to general hospitals. Europace. 2003;5:283–91.CrossRef
7.
go back to reference van Dijk N, Boer KR, Colman N, et al. High diagnostic yield and accuracy of history, physical examination, and ECG in patients with transient loss of consciousness in FAST: the fainting assessment study. J Cardiovasc Electrophysiol. 2008;19:48–55.CrossRef van Dijk N, Boer KR, Colman N, et al. High diagnostic yield and accuracy of history, physical examination, and ECG in patients with transient loss of consciousness in FAST: the fainting assessment study. J Cardiovasc Electrophysiol. 2008;19:48–55.CrossRef
8.
go back to reference Sarasin FP, Louis-Simonet M, Carballo D, et al. Prospective evaluation of patients with syncope: a population-based study. Am J Med. 2001;111:177–84.CrossRef Sarasin FP, Louis-Simonet M, Carballo D, et al. Prospective evaluation of patients with syncope: a population-based study. Am J Med. 2001;111:177–84.CrossRef
9.
go back to reference Brignole M, Ungar A, Bartoletti A, et al. Standardized-care pathway vs. usual management of syncope patients presenting as emergencies at general hospitals. Europace. 2006;8:644–50.CrossRef Brignole M, Ungar A, Bartoletti A, et al. Standardized-care pathway vs. usual management of syncope patients presenting as emergencies at general hospitals. Europace. 2006;8:644–50.CrossRef
10.
go back to reference Olde Nordkamp LR, van Dijk N, Ganzeboom KS, et al. Syncope prevalence in the ED compared to general practice and population: a strong selection process. Am J Emerg Med. 2009;27:271–9.CrossRef Olde Nordkamp LR, van Dijk N, Ganzeboom KS, et al. Syncope prevalence in the ED compared to general practice and population: a strong selection process. Am J Emerg Med. 2009;27:271–9.CrossRef
11.
go back to reference Blanc JJ, L’Her C, Touiza A, et al. Prospective evaluation and outcome of patients admitted for syncope over a 1 year period. Eur Heart J. 2002;23:815–20.CrossRef Blanc JJ, L’Her C, Touiza A, et al. Prospective evaluation and outcome of patients admitted for syncope over a 1 year period. Eur Heart J. 2002;23:815–20.CrossRef
12.
go back to reference Grossman SA, Babineau M, Burke L, et al. Do outcomes of near syncope parallel syncope? Am J Emerg Med. 2012;30:203–6.CrossRef Grossman SA, Babineau M, Burke L, et al. Do outcomes of near syncope parallel syncope? Am J Emerg Med. 2012;30:203–6.CrossRef
13.
go back to reference Wieling W, van Dijk N, de Lange FJ, et al. History taking as a diagnostic test in patients with syncope: developing expertise in syncope. Eur Heart J. 2015;36:277–80.CrossRef Wieling W, van Dijk N, de Lange FJ, et al. History taking as a diagnostic test in patients with syncope: developing expertise in syncope. Eur Heart J. 2015;36:277–80.CrossRef
14.
go back to reference Sutton R, van Dijk N, Wieling W. Clinical history in management of suspected syncope: a powerful diagnostic tool. Cardiol J. 2014;21:651–7.CrossRef Sutton R, van Dijk N, Wieling W. Clinical history in management of suspected syncope: a powerful diagnostic tool. Cardiol J. 2014;21:651–7.CrossRef
15.
go back to reference Wieling W, Thijs RD, Linzer M, et al. Great expectations: what patients with unexplained syncope desire. J Intern Med. 2016;279:259–64.CrossRef Wieling W, Thijs RD, Linzer M, et al. Great expectations: what patients with unexplained syncope desire. J Intern Med. 2016;279:259–64.CrossRef
16.
go back to reference van Dijk JG, Thijs RD, Benditt DG, et al. A guide to disorders causing transient loss of consciousness: focus on syncope. Nat Rev Neurol. 2009;5:438–48.CrossRef van Dijk JG, Thijs RD, Benditt DG, et al. A guide to disorders causing transient loss of consciousness: focus on syncope. Nat Rev Neurol. 2009;5:438–48.CrossRef
17.
go back to reference Krediet CT, Jardine DL, Wieling W. Dissection of carotid sinus hypersensitivity: the timing of vagal and vasodepressor effects and the effect of body position. Clin Sci (Lond). 2011;121:389–96.CrossRef Krediet CT, Jardine DL, Wieling W. Dissection of carotid sinus hypersensitivity: the timing of vagal and vasodepressor effects and the effect of body position. Clin Sci (Lond). 2011;121:389–96.CrossRef
18.
go back to reference Benditt DG. Syncope risk assessment in the emergency department and clinic. Prog Cardiovasc Dis. 2013;55:376–81.CrossRef Benditt DG. Syncope risk assessment in the emergency department and clinic. Prog Cardiovasc Dis. 2013;55:376–81.CrossRef
19.
go back to reference Shin TG, Kim JS, Song HG, et al. Standardized approaches to syncope evaluation for reducing hospital admissions and costs in overcrowded emergency departments, Yonsei. Med J. 2013;54:1110–8. Shin TG, Kim JS, Song HG, et al. Standardized approaches to syncope evaluation for reducing hospital admissions and costs in overcrowded emergency departments, Yonsei. Med J. 2013;54:1110–8.
20.
go back to reference Cannom DS. History of syncope in the cardiac literature. Prog Cardiovasc Dis. 2013;55:334–8.CrossRef Cannom DS. History of syncope in the cardiac literature. Prog Cardiovasc Dis. 2013;55:334–8.CrossRef
21.
go back to reference Wieling W, Thijs RD, van Dijk N, et al. Symptoms and signs of syncope: a review of the link between physiology and clinical clues. Brain. 2009;132:2630–42.CrossRef Wieling W, Thijs RD, van Dijk N, et al. Symptoms and signs of syncope: a review of the link between physiology and clinical clues. Brain. 2009;132:2630–42.CrossRef
22.
go back to reference de Jong JSY, de Lange FJ, van Dijk N, et al. Syncopedia: training a new generation of syncope specialists. Clin Auton Res. 2018;28:173–6. de Jong JSY, de Lange FJ, van Dijk N, et al. Syncopedia: training a new generation of syncope specialists. Clin Auton Res. 2018;28:173–6.
23.
go back to reference Soteriades ES, Evans JC, Larson MG, et al. Incidence and prognosis of syncope. N Engl J Med. 2002;347:878–85.CrossRef Soteriades ES, Evans JC, Larson MG, et al. Incidence and prognosis of syncope. N Engl J Med. 2002;347:878–85.CrossRef
24.
go back to reference Toarta C, Mukarram M, Arcot K, et al. Syncope prognosis based on emergency department diagnosis: a prospective cohort study. Acad Emerg Med. 2018;25:388–96.CrossRef Toarta C, Mukarram M, Arcot K, et al. Syncope prognosis based on emergency department diagnosis: a prospective cohort study. Acad Emerg Med. 2018;25:388–96.CrossRef
25.
go back to reference Ricci F, De Caterina R, Fedorowski A. Orthostatic hypotension: epidemiology, prognosis, and treatment. J Am Coll Cardiol. 2015;66:848–60.CrossRef Ricci F, De Caterina R, Fedorowski A. Orthostatic hypotension: epidemiology, prognosis, and treatment. J Am Coll Cardiol. 2015;66:848–60.CrossRef
26.
go back to reference Romme JJ, Reitsma JB, Go-Schon IK, et al. Prospective evaluation of non-pharmacological treatment in vasovagal syncope. Europace. 2010;12:567–73.CrossRef Romme JJ, Reitsma JB, Go-Schon IK, et al. Prospective evaluation of non-pharmacological treatment in vasovagal syncope. Europace. 2010;12:567–73.CrossRef
27.
go back to reference van Wijnen VK, Harms MP, Go-Schon IK, et al. Initial orthostatic hypotension in teenagers and young adults. Clin Auton Res. 2016;26:441–9.CrossRef van Wijnen VK, Harms MP, Go-Schon IK, et al. Initial orthostatic hypotension in teenagers and young adults. Clin Auton Res. 2016;26:441–9.CrossRef
28.
go back to reference van Wijnen VK, Finucane C, Harms MPM, et al. Noninvasive beat-to-beat finger arterial pressure monitoring during orthostasis: a comprehensive review of normal and abnormal responses at different ages. J Intern Med. 2017;282:468–83.CrossRef van Wijnen VK, Finucane C, Harms MPM, et al. Noninvasive beat-to-beat finger arterial pressure monitoring during orthostasis: a comprehensive review of normal and abnormal responses at different ages. J Intern Med. 2017;282:468–83.CrossRef
29.
go back to reference Kenny RA, Brignole M, Dan GA, et al. Syncope unit: rationale and requirement--the European heart rhythm association position statement endorsed by the Heart Rhythm Society. Europace. 2015;17:1325–40.CrossRef Kenny RA, Brignole M, Dan GA, et al. Syncope unit: rationale and requirement--the European heart rhythm association position statement endorsed by the Heart Rhythm Society. Europace. 2015;17:1325–40.CrossRef
Metadata
Title
Diagnostic accuracy of evaluation of suspected syncope in the emergency department: usual practice vs. ESC guidelines
Authors
Veera K. van Wijnen
Reinold O. B. Gans
Wouter Wieling
Jan C. ter Maaten
Mark P. M. Harms
Publication date
01-12-2020
Publisher
BioMed Central
Keyword
Cardiac Syncope
Published in
BMC Emergency Medicine / Issue 1/2020
Electronic ISSN: 1471-227X
DOI
https://doi.org/10.1186/s12873-020-00344-9

Other articles of this Issue 1/2020

BMC Emergency Medicine 1/2020 Go to the issue