Published in:
01-12-2020 | Cardiac Amyloidosis | Images that Teach
Light-chain cardiac amyloidosis: A multimodality approach
Authors:
Erick Alexanderson-Rosas, MD, Mara Escudero-Salamanca, MD, Jesus A. Garcia-Diaz, MD, Ricardo Alvarez-Santana, MD, Roberto Cano-Zarate, MD, Julio Mamani-Tito, MD, Isabel Carvajal-Juarez, MD, Nilda Espinola-Zavaleta, MD, PhD
Published in:
Journal of Nuclear Cardiology
|
Issue 6/2020
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Excerpt
Amyloidosis is a multisystemic disease, caused by deposits of misfolded protein fragments. There are two main types of amyloidosis, the light-chain (AL) and transthyretin-related amyloidosis, both of them, affect the heart. Cardiac affection usually manifests with heart failure. The non-invasive diagnostic methods used to establish the diagnosis are echocardiography, cardiac magnetic resonance (CMR) and pyrophosphate scintigraphy.
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3 Endomyocardial biopsy is the gold standard for diagnosis of cardiac amyloidosis, however, CMR, single-photon emission computed tomography using specific amyloid radiotracers have been shown to have high sensitivity and specificity.
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