Published in:
15-03-2021 | Cardiac Amyloidosis | IMAGES THAT TEACH
Imaging an ATTR cardiac amyloidosis patient using fluorine-18 sodium fluoride PET/CT: A case report
Authors:
Supanida Mayurasakorn, MD, Peerapon Kiatkittikul, MD, Chanisa Chotipanich, MD, Chetsadaporn Promteangtrong, MD, Anchisa Kunawudhi, MD, Dheeratama Siripongsatian, MD, Chanidapa Iamsa-art, RT
Published in:
Journal of Nuclear Cardiology
|
Issue 6/2022
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Excerpt
Cardiac amyloidosis (CA) is a disease caused by a build-up of protein aggregations known as amyloids in cardiac tissue. As the deposits increase, the heart muscles become increasingly stiff, and eventually, the pumping function deteriorates.
1 There are two main types of amyloidosis: light-chain (AL) amyloidosis and transthyretin (ATTR) amyloidosis. If ATTR-CA is suspected, the diagnosis can usually be confirmed by an endomyocardial biopsy. Alternatively, it can be diagnosed non-invasively by bone scintigraphy using Technetium-99m pyrophosphate (Tc-99m- PYP), Tc-99m-diphosphono-1,2-propanodicarboxylic acid (Tc-99m-DPD), or Tc-99m-hydroxymethylene diphosphonate (Tc-99m-HMDP) in the absence of abnormal light chains on serum free light-chain assays and immunofixation of the serum and urine.
2 However, other bone tracers can assist in the diagnosis of ATTR-CA, including fluorine-18 sodium fluoride (18F-NaF). In this case report, we will show positive 18F-NaF PET/CT images of an ATTR-CA patient. …
