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Open Access 01-12-2022 | Carcinoid Tumor | Case Report

Coexistence of carcinoid tumor and adenocarcinoma of the lung; morphological, immunohistochemical and genetic analyses, a case report

Authors: Chihiro Inoue, Sachiko Konosu-Fukaya, Kazuhiro Murakami, Ryoko Saito-Koyama, Hirofumi Watanabe, Hideki Mitomo, Naoya Ishibashi, Takafumi Sugawara, Toshiharu Tabata, Hironobu Sasano, Yasuhiro Nakamura

Published in: Diagnostic Pathology | Issue 1/2022

Abstract

Background

Pulmonary carcinoid tumors rarely coexist with non-small cell lung carcinoma, and only nine cases have been reported previously. The pathogenesis and origin of these combined tumors remain unclear because of its rarity.

Case presentation

We examined two cases of adenocarcinoma coexisting with a typical or atypical carcinoid tumor: Case 1 was a 77-year-old woman and Case 2 was an 83-year-old woman. Both of these cases had no respiratory symptoms, and underwent pulmonary lobectomies due to incidentally detected lung nodules. Recurrence and metastases were not detected after the surgery. Histologically, carcinoid and adenocarcinoma components were present in both cases. The two components coexisted without mixing with each other. Next-generation sequencing was performed on the two components in these cases. In each case, no common genetic variants were detected.

Conclusion

We considered that our cases could histologically and genetically represent collision tumors that did not share common progenitor cells. Comprehensive analyses such as whole genome sequencing could provide important information for elucidating the pathogenesis of adenocarcinoma and carcinoid components.

Travis WD, Brambilla E, Burke AP, Marx A, Nicholson AG. WHO classification of Tumours of the lung, pleura, Thymus and heart: WHO classification of Tumours. 4th ed. Lyon: International Agency for Research on Cancer; 2015.

Sen F, Borczuk AC. Combined carcinoid tumor of the lung: a combination of carcinoid and adenocarcinoma. Lung Cancer. 1998;21(1):53–8. https://doi.org/10.1016/S0169-5002(98)00042-7.CrossRefPubMed

Owens CL, Fraire AE. Combined carcinoid tumor and squamous cell carcinoma of lung: expanding the spectrum of combined tumors of lung. Int J Surg Pathol. 2011;19(2):273–5. https://doi.org/10.1177/1066896910397883.CrossRefPubMed

Abbi KKS, Hameed MK, Jiang Y, De Las Casas LE, Schwann TA. Pulmonary collision tumor consisting of adenocarcinoma and typical carcinoid-a case report and review of literature. Am J Ther. 2014;21(6):e234–8. https://doi.org/10.1097/MJT.0b013e318293b0b0.CrossRefPubMed

Okazaki M, Sano Y, Soga Y, Katayama H, Sakao N, Shikatani Y, et al. Combined atypical carcinoid tumour and squamous cell carcinoma of the lung. Intern Med. 2015;54(11):1385–8. https://doi.org/10.2169/internalmedicine.54.3846.CrossRefPubMed

Olofson AM, Tafe LJ. A case of a primary lung cancer comprised of adenocarcinoma and atypical carcinoid tumor with both components harboring BRAF p.V600E mutation. Exp Mol Pathol. 2018;104:26–8 Available from: https://doi.org/10.1016/j.yexmp.2017.12.004.CrossRef

Nagamatsu Y, Iwasaki Y, Omura H, Kumazoe H, Hyashida R, Shirouzu K. A case of resected synchronous multiple primary lung cancer comprising adenocarcinoma and carcinoid (cancer-in-cancer). Gen Thorac Cardiovasc Surg. 2012;60(8):518–21. https://doi.org/10.1007/s11748-012-0029-z.CrossRefPubMed

Ruffini E, Rena O, Oliaro A, Filosso PL, Bongiovanni M, Arslanian A, et al. Lung tumors with mixed histologic pattern. Clinico-pathologic characteristics and prognostic significance. Eur J Cardio-thoracic Surg. 2002;22(5):701–7. https://doi.org/10.1016/S1010-7940(02)00481-5.CrossRef

Li DH, Wang C, Chen HJ, Huang H, Ding ZY. Clinical characteristics of the mixed form of neuroendocrine tumor in the lung: a retrospective study in 2501 lung cancer cases. Thorac Cancer. 2015;6(1):25–30. https://doi.org/10.1111/1759-7714.12128.CrossRefPubMedPubMedCentral

10.

Vogt A, Schmid S, Heinimann K, Frick H, Herrmann C, Cerny T, et al. Multiple primary tumours: challenges and approaches, a review. ESMO Open. 2017;2(2):1–11. https://doi.org/10.1136/esmoopen-2017-000172.CrossRef

11.

Swarts DRA, Ramaekers FCS, Speel EJM. Molecular and cellular biology of neuroendocrine lung tumors: Evidence for separate biological entities. Biochim Biophys Acta - Rev Cancer. 2012;1826:255–71. https://doi.org/10.1016/j.bbcan.2012.05.001.CrossRef

12.

Furlan D, Cerutti R, Genasetti A, Pelosi G, Uccella S, La Rosa S, et al. Microallelotyping defines the monoclonal or the polyclonal origin of mixed and collision endocrine-exocrine tumors of the gut. Lab Investig. 2003;83(7):963–71. https://doi.org/10.1097/01.LAB.0000079006.91414.BE.CrossRefPubMed

13.

La Rosa S, Chiaravalli AM, Placidi C, Papanikolaou N, Cerati M, Capella C. TTF1 expression in normal lung neuroendocrine cells and related tumors: Immunohistochemical study comparing two different monoclonal antibodies. Virchows Arch. 2010;457(4):497–507. https://doi.org/10.1007/s00428-010-0954-0.CrossRefPubMed

14.

Du EZ, Goldstraw P, Zacharias J, Tiffet O, Craig PJ, Nicholson AG, et al. TTF-1 expression is specific for lung primary in typical and atypical carcinoids: TTF-1-positive carcinoids are predominantly in peripheral location. Hum Pathol. 2004;35(7):825–31. https://doi.org/10.1016/j.humpath.2004.02.016.CrossRefPubMed

15.

Ouadah Y, Rojas ER, Riordan DP, Capostagno S, Kuo CS, Krasnow MA. Rare pulmonary neuroendocrine cells are stem cells regulated by Rb, p53, and notch. Cell. 2019;179:403–16.e23 Available from: https://doi.org/10.1016/j.cell.2019.09.010.CrossRef

16.

Reynolds SD, Giangreco A, JHT P, Stripp BR. Neuroepithelial bodies of pulmonary airways serve as a reservoir of progenitor cells capable of epithelial regeneration. Am J Pathol. 2000;156:269–78. https://doi.org/10.1016/S0002-9440(10)64727-X.CrossRefPubMedPubMedCentral

Title: Coexistence of carcinoid tumor and adenocarcinoma of the lung; morphological, immunohistochemical and genetic analyses, a case report
Authors: Chihiro Inoue
Sachiko Konosu-Fukaya
Kazuhiro Murakami
Ryoko Saito-Koyama
Hirofumi Watanabe
Hideki Mitomo
Naoya Ishibashi
Takafumi Sugawara
Toshiharu Tabata
Hironobu Sasano
Yasuhiro Nakamura
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: Carcinoid Tumor
SCLC
SCLC
Lung Cancer
Lung Cancer
Lung Cancer
Published in: Diagnostic Pathology / Issue 1/2022
Electronic ISSN: 1746-1596
DOI: https://doi.org/10.1186/s13000-022-01208-5

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Springer Medicine

Coexistence of carcinoid tumor and adenocarcinoma of the lung; morphological, immunohistochemical and genetic analyses, a case report

Abstract

Background

Case presentation

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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